Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.
(2006) In Diabetologia 49(9). p.2192-2199- Abstract
- AIMS/HYPOTHESIS: It has been suggested that the uterine environment may influence metabolic disease occurring later in adult life, and that adult stress may promote disease outcome. Using a mouse model, we tested whether in utero exposure to Ljungan virus (LV) followed by adult exposure to stress produces diabetes. The influence of the timing of viral exposure over the course of pregnancy was also tested. MATERIALS AND METHODS: Pregnant CD-1 mice were exposed i.p. to LV on pregnancy days 4, 8, 12 or 17. Adult male mice from these pregnancies were stressed by being kept in shared cages. Stress only, LV exposure in utero only, and no-stress/no virus exposure groups were also followed. Outcome variables included bodyweight, epididymal fat... (More)
- AIMS/HYPOTHESIS: It has been suggested that the uterine environment may influence metabolic disease occurring later in adult life, and that adult stress may promote disease outcome. Using a mouse model, we tested whether in utero exposure to Ljungan virus (LV) followed by adult exposure to stress produces diabetes. The influence of the timing of viral exposure over the course of pregnancy was also tested. MATERIALS AND METHODS: Pregnant CD-1 mice were exposed i.p. to LV on pregnancy days 4, 8, 12 or 17. Adult male mice from these pregnancies were stressed by being kept in shared cages. Stress only, LV exposure in utero only, and no-stress/no virus exposure groups were also followed. Outcome variables included bodyweight, epididymal fat weight, baseline glucose, glucose tolerance tests (60 and 120 min) and serum insulin. RESULTS: We demonstrated that male mice developed a type 2-like diabetes, including obesity, as adults if infected during pregnancy with LV. Diabetes at the age of 11 w (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1136276
- author
- Niklasson, B ; Samsioe, A ; Blixt, M ; Sandler, S ; Sjöholm, A ; Lagerquist, E ; Lernmark, Åke LU and Klitz, W
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diabetes, Fetal programming, Ljungan virus, Mouse model, Stress, Type 2 diabetes
- in
- Diabetologia
- volume
- 49
- issue
- 9
- pages
- 2192 - 2199
- publisher
- Springer
- external identifiers
-
- scopus:33746695448
- pmid:16821045
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-006-0339-8
- language
- English
- LU publication?
- no
- id
- 95874882-14f8-4cfc-b2e4-5692be23527d (old id 1136276)
- date added to LUP
- 2016-04-01 11:46:08
- date last changed
- 2022-03-28 02:48:09
@article{95874882-14f8-4cfc-b2e4-5692be23527d, abstract = {{AIMS/HYPOTHESIS: It has been suggested that the uterine environment may influence metabolic disease occurring later in adult life, and that adult stress may promote disease outcome. Using a mouse model, we tested whether in utero exposure to Ljungan virus (LV) followed by adult exposure to stress produces diabetes. The influence of the timing of viral exposure over the course of pregnancy was also tested. MATERIALS AND METHODS: Pregnant CD-1 mice were exposed i.p. to LV on pregnancy days 4, 8, 12 or 17. Adult male mice from these pregnancies were stressed by being kept in shared cages. Stress only, LV exposure in utero only, and no-stress/no virus exposure groups were also followed. Outcome variables included bodyweight, epididymal fat weight, baseline glucose, glucose tolerance tests (60 and 120 min) and serum insulin. RESULTS: We demonstrated that male mice developed a type 2-like diabetes, including obesity, as adults if infected during pregnancy with LV. Diabetes at the age of 11 w}}, author = {{Niklasson, B and Samsioe, A and Blixt, M and Sandler, S and Sjöholm, A and Lagerquist, E and Lernmark, Åke and Klitz, W}}, issn = {{1432-0428}}, keywords = {{Diabetes; Fetal programming; Ljungan virus; Mouse model; Stress; Type 2 diabetes}}, language = {{eng}}, number = {{9}}, pages = {{2192--2199}}, publisher = {{Springer}}, series = {{Diabetologia}}, title = {{Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.}}, url = {{http://dx.doi.org/10.1007/s00125-006-0339-8}}, doi = {{10.1007/s00125-006-0339-8}}, volume = {{49}}, year = {{2006}}, }