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Sensing extracellular matrix: an update on discoidin domain receptor function

Vogel, Wolfgang F ; Abdulhussein, Rahim and Ford, Caroline LU (2006) In Cellular Signalling 18(8). p.1108-1116
Abstract
Discoidin Domain Receptors (DDRs) have recently emerged as non-integrin-type receptors for collagen. The two mammalian gene products Discoidin Domain Receptor 1 and -2 constitute a subfamily of tyrosine kinase receptors that are selectively expressed in a number of different cell types and organs. Upon collagen activation, DDRs regulate cell adhesion, proliferation and extracellular matrix remodeling. Here we review the various signaling pathways and cellular responses evoked by activated DDRs. Additionally, we give an overview of the more recent advances in understanding the role of DDRs in various human diseases, in particular during tumor progression, atherosclerosis, inflammation and tissue fibrosis. Furthermore, we discuss potential... (More)
Discoidin Domain Receptors (DDRs) have recently emerged as non-integrin-type receptors for collagen. The two mammalian gene products Discoidin Domain Receptor 1 and -2 constitute a subfamily of tyrosine kinase receptors that are selectively expressed in a number of different cell types and organs. Upon collagen activation, DDRs regulate cell adhesion, proliferation and extracellular matrix remodeling. Here we review the various signaling pathways and cellular responses evoked by activated DDRs. Additionally, we give an overview of the more recent advances in understanding the role of DDRs in various human diseases, in particular during tumor progression, atherosclerosis, inflammation and tissue fibrosis. Furthermore, we discuss potential roles of genes homologous to mammalian DDRs identified in flies, worms and sponges. We show that the structural organization of these DDR-related genes is highly conserved throughout evolution suggesting that invertebrate DDRs may also function as receptors for collagen. By highlighting current questions about these unusual collagen receptors, we hope to attract new research on DDRs from a variety of different fields. (Less)
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author
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organization
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type
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publication status
published
subject
keywords
Extracellular matrix, Collagen, Tyrosine kinase, Discoidin domain, Receptor signaling, Molecular evolution
in
Cellular Signalling
volume
18
issue
8
pages
1108 - 1116
publisher
Elsevier
external identifiers
  • pmid:16626936
  • scopus:33646341752
ISSN
1873-3913
DOI
10.1016/j.cellsig.2006.02.012
language
English
LU publication?
yes
id
679afc0b-9ae0-4fed-86c0-cbb65fabd9b1 (old id 1136312)
date added to LUP
2016-04-01 12:04:29
date last changed
2021-08-04 02:57:57
@article{679afc0b-9ae0-4fed-86c0-cbb65fabd9b1,
  abstract     = {Discoidin Domain Receptors (DDRs) have recently emerged as non-integrin-type receptors for collagen. The two mammalian gene products Discoidin Domain Receptor 1 and -2 constitute a subfamily of tyrosine kinase receptors that are selectively expressed in a number of different cell types and organs. Upon collagen activation, DDRs regulate cell adhesion, proliferation and extracellular matrix remodeling. Here we review the various signaling pathways and cellular responses evoked by activated DDRs. Additionally, we give an overview of the more recent advances in understanding the role of DDRs in various human diseases, in particular during tumor progression, atherosclerosis, inflammation and tissue fibrosis. Furthermore, we discuss potential roles of genes homologous to mammalian DDRs identified in flies, worms and sponges. We show that the structural organization of these DDR-related genes is highly conserved throughout evolution suggesting that invertebrate DDRs may also function as receptors for collagen. By highlighting current questions about these unusual collagen receptors, we hope to attract new research on DDRs from a variety of different fields.},
  author       = {Vogel, Wolfgang F and Abdulhussein, Rahim and Ford, Caroline},
  issn         = {1873-3913},
  language     = {eng},
  number       = {8},
  pages        = {1108--1116},
  publisher    = {Elsevier},
  series       = {Cellular Signalling},
  title        = {Sensing extracellular matrix: an update on discoidin domain receptor function},
  url          = {http://dx.doi.org/10.1016/j.cellsig.2006.02.012},
  doi          = {10.1016/j.cellsig.2006.02.012},
  volume       = {18},
  year         = {2006},
}