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Deprenyl: from chemical synthesis to neuroprotection.

Magyar, K. ; Palfi, M. ; Jenei, Veronica LU and Szoko, E. (2006) In Journal of neural transmission. Supplementum 71. p.143-156
Abstract
During the last decades (-)-deprenyl has become the golden standard of MAO-B inhibitors. It possesses dopamine potentiating and antioxidant properties; however, its effects cannot be explained solely by the enzyme inhibitory action. (-)-Deprenyl prevents the toxicity of certain selective neurotoxins and recently it was demonstrated to increase cell-cell adhesion as well. The complexity of its pharmacological effects reflects the action of both the parent compound and the active metabolites. (-)-Deprenyl and related propargylamines (DRPs) show neuroprotective features in a variety of in vitro and in vivo models that is dependent on the propargyl moiety. The main presumptive targets to date include glyceraldehyde-3-phosphate dehydrogenase,... (More)
During the last decades (-)-deprenyl has become the golden standard of MAO-B inhibitors. It possesses dopamine potentiating and antioxidant properties; however, its effects cannot be explained solely by the enzyme inhibitory action. (-)-Deprenyl prevents the toxicity of certain selective neurotoxins and recently it was demonstrated to increase cell-cell adhesion as well. The complexity of its pharmacological effects reflects the action of both the parent compound and the active metabolites. (-)-Deprenyl and related propargylamines (DRPs) show neuroprotective features in a variety of in vitro and in vivo models that is dependent on the propargyl moiety. The main presumptive targets to date include glyceraldehyde-3-phosphate dehydrogenase, poly(ADP-ribose) polymerase, some kinase cascades, as well as pro- and antiapoptotic proteins, beside the inhibition of MAO-B. The antiapoptotic activity of DRPs converges upon the maintenance of mitochondrial integrity, due to the initiation of a comp (Less)
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type
Contribution to journal
publication status
published
subject
in
Journal of neural transmission. Supplementum
volume
71
pages
143 - 156
publisher
Springer
external identifiers
  • scopus:34248550986
ISSN
0303-6995
language
English
LU publication?
yes
id
3eaed409-d170-44a0-9758-ff2b58577236 (old id 1136388)
date added to LUP
2016-04-01 16:59:45
date last changed
2021-10-06 05:02:09
@article{3eaed409-d170-44a0-9758-ff2b58577236,
  abstract     = {During the last decades (-)-deprenyl has become the golden standard of MAO-B inhibitors. It possesses dopamine potentiating and antioxidant properties; however, its effects cannot be explained solely by the enzyme inhibitory action. (-)-Deprenyl prevents the toxicity of certain selective neurotoxins and recently it was demonstrated to increase cell-cell adhesion as well. The complexity of its pharmacological effects reflects the action of both the parent compound and the active metabolites. (-)-Deprenyl and related propargylamines (DRPs) show neuroprotective features in a variety of in vitro and in vivo models that is dependent on the propargyl moiety. The main presumptive targets to date include glyceraldehyde-3-phosphate dehydrogenase, poly(ADP-ribose) polymerase, some kinase cascades, as well as pro- and antiapoptotic proteins, beside the inhibition of MAO-B. The antiapoptotic activity of DRPs converges upon the maintenance of mitochondrial integrity, due to the initiation of a comp},
  author       = {Magyar, K. and Palfi, M. and Jenei, Veronica and Szoko, E.},
  issn         = {0303-6995},
  language     = {eng},
  pages        = {143--156},
  publisher    = {Springer},
  series       = {Journal of neural transmission. Supplementum},
  title        = {Deprenyl: from chemical synthesis to neuroprotection.},
  volume       = {71},
  year         = {2006},
}