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Neurogenesis in the adult spinal cord in an experimental model of multiple sclerosis

Danilov, Alexandre LU ; Covacu, Ruxandra ; Moe, Morten C ; Langmoen, Iver A ; Johansson, Clas B ; Olsson, Tomas and Brundin, Lou (2006) In European Journal of Neuroscience 23(2). p.394-400
Abstract
Multiple sclerosis is an inflammatory disease of the central nervous system characterized by inflammation, demyelination, axonal degeneration and accumulation of neurological disability. Previously, we demonstrated that stem cells constitute a possible endogenous source for remyelination. We now addressed the question of whether neurogenesis can occur in neuroinflammatory lesions. We demonstrated that, in experimental autoimmune encephalomyelitis, induced in rats 1,1'-dioctadecyl-6,6'-di(4sulphopentyl)-3,3,3',3'tetramethylindocarbocyani n(DiI)-labelled ependymal cells not only proliferated but descendants migrated to the area of neuroinflammation and differentiated into cells expressing the neuronal markers beta-III-tubulin and NeuN.... (More)
Multiple sclerosis is an inflammatory disease of the central nervous system characterized by inflammation, demyelination, axonal degeneration and accumulation of neurological disability. Previously, we demonstrated that stem cells constitute a possible endogenous source for remyelination. We now addressed the question of whether neurogenesis can occur in neuroinflammatory lesions. We demonstrated that, in experimental autoimmune encephalomyelitis, induced in rats 1,1'-dioctadecyl-6,6'-di(4sulphopentyl)-3,3,3',3'tetramethylindocarbocyani n(DiI)-labelled ependymal cells not only proliferated but descendants migrated to the area of neuroinflammation and differentiated into cells expressing the neuronal markers beta-III-tubulin and NeuN. Furthermore, these cells were immunoreactive for bromodeoxyuridine and PCNA, markers for cells undergoing cell proliferation. Using the whole-cell patch-clamp technique on freshly isolated 1, DiI-labelled cells from spinal cord lesions we demonstrated the ability of these cells to fire overshooting action potentials similar to those of immature neurones. We thus provide the first evidence for the initiation of neurogenesis in neuroinflammatory lesions in the adult spinal cord. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Neuroscience
volume
23
issue
2
pages
394 - 400
publisher
Wiley-Blackwell
external identifiers
  • pmid:16420447
  • scopus:33644936254
  • pmid:16420447
ISSN
1460-9568
DOI
10.1111/j.1460-9568.2005.04563.x
language
English
LU publication?
yes
id
e7ce87e2-f120-40ac-8bb9-26ee9e27f007 (old id 1136678)
date added to LUP
2016-04-01 12:31:13
date last changed
2021-09-08 02:36:20
@article{e7ce87e2-f120-40ac-8bb9-26ee9e27f007,
  abstract     = {Multiple sclerosis is an inflammatory disease of the central nervous system characterized by inflammation, demyelination, axonal degeneration and accumulation of neurological disability. Previously, we demonstrated that stem cells constitute a possible endogenous source for remyelination. We now addressed the question of whether neurogenesis can occur in neuroinflammatory lesions. We demonstrated that, in experimental autoimmune encephalomyelitis, induced in rats 1,1'-dioctadecyl-6,6'-di(4sulphopentyl)-3,3,3',3'tetramethylindocarbocyani n(DiI)-labelled ependymal cells not only proliferated but descendants migrated to the area of neuroinflammation and differentiated into cells expressing the neuronal markers beta-III-tubulin and NeuN. Furthermore, these cells were immunoreactive for bromodeoxyuridine and PCNA, markers for cells undergoing cell proliferation. Using the whole-cell patch-clamp technique on freshly isolated 1, DiI-labelled cells from spinal cord lesions we demonstrated the ability of these cells to fire overshooting action potentials similar to those of immature neurones. We thus provide the first evidence for the initiation of neurogenesis in neuroinflammatory lesions in the adult spinal cord.},
  author       = {Danilov, Alexandre and Covacu, Ruxandra and Moe, Morten C and Langmoen, Iver A and Johansson, Clas B and Olsson, Tomas and Brundin, Lou},
  issn         = {1460-9568},
  language     = {eng},
  number       = {2},
  pages        = {394--400},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Neuroscience},
  title        = {Neurogenesis in the adult spinal cord in an experimental model of multiple sclerosis},
  url          = {http://dx.doi.org/10.1111/j.1460-9568.2005.04563.x},
  doi          = {10.1111/j.1460-9568.2005.04563.x},
  volume       = {23},
  year         = {2006},
}