Sarcoidosis and Autoimmunity: Evidence of Differential Associations with HLA Class II Markers
(2006) In International Journal of Endocrinology and Metabolism 4(1). p.13-18- Abstract
- A high frequency of endocrine autoimmunity
and gastrointestinal immune
reactivity has been reported in sarcoidosis.
The aim of the present study was
to determine the immunogenetic background of
sarcoidosis focusing on the associated autoimmune
manifestations.
Materials and Methods: A total of 66 (38 males,
28 females) and /65 (37 males, 28 females) Caucasian
patients with documented sarcoidosis diagnosed
at the Department of Pulmonary Medicine,
Malmö University Hospital were genomically
typed for DRB1/DQB1.
Results: The frequencies of HLA-DRB1*02
(p=0.004), DRB1*14 (p=0.022), DQB1*0602
(p=0.027), DQB1*0503... (More) - A high frequency of endocrine autoimmunity
and gastrointestinal immune
reactivity has been reported in sarcoidosis.
The aim of the present study was
to determine the immunogenetic background of
sarcoidosis focusing on the associated autoimmune
manifestations.
Materials and Methods: A total of 66 (38 males,
28 females) and /65 (37 males, 28 females) Caucasian
patients with documented sarcoidosis diagnosed
at the Department of Pulmonary Medicine,
Malmö University Hospital were genomically
typed for DRB1/DQB1.
Results: The frequencies of HLA-DRB1*02
(p=0.004), DRB1*14 (p=0.022), DQB1*0602
(p=0.027), DQB1*0503 (p=0.022), were significantly
increased in the whole group of patients
with sarcoidosis as well as in sarcoidosis associated
with autoimmune manifestations compared
to healthy controls.
Conclusions: Significant associations of HLADRB1*
02 and *14 and DQB1*0602 and *0503 with
sarcoidosis were found, particularly apparent in
the subgroup with associated autoimmune manifestations.
Different immunogenetic profiles
may thus exist in sarcoidosis indicative and/or
causative of distinct clinical subgroups. HLA
class II presentation of a putative sarcoidosisspecific
antigen might be of vital importance in
sarcoidosis, deciding the direction of the sarcoid
disease and eventual associations with it.
Whether the above mentioned HLA class II haplotypes
and/or their linked genes, alone or in
unison with HLA class I, are organ- or diseasespecific
remains to be determined. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1137005
- author
- Papadopoulos, K I ; Wassmuth, R ; Sponsel, T ; Sjöberg, K and Hallengren, Bengt LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Sarcoidosis, Thyroid, Polyglandular Autoimmune Syndromes, HLA, Autoimmunity
- in
- International Journal of Endocrinology and Metabolism
- volume
- 4
- issue
- 1
- pages
- 13 - 18
- publisher
- Iran Endocrine Society, Shaheed Beheshti University of Medical Sciences
- ISSN
- 1726-913X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 76f81589-2e53-4624-a753-3bbad37cf510 (old id 1137005)
- alternative location
- http://www.ijem.org/PDF/Vol4No1.pdf
- date added to LUP
- 2016-04-01 15:20:45
- date last changed
- 2018-11-21 20:33:58
@article{76f81589-2e53-4624-a753-3bbad37cf510, abstract = {{A high frequency of endocrine autoimmunity<br/><br> and gastrointestinal immune<br/><br> reactivity has been reported in sarcoidosis.<br/><br> The aim of the present study was<br/><br> to determine the immunogenetic background of<br/><br> sarcoidosis focusing on the associated autoimmune<br/><br> manifestations.<br/><br> Materials and Methods: A total of 66 (38 males,<br/><br> 28 females) and /65 (37 males, 28 females) Caucasian<br/><br> patients with documented sarcoidosis diagnosed<br/><br> at the Department of Pulmonary Medicine,<br/><br> Malmö University Hospital were genomically<br/><br> typed for DRB1/DQB1.<br/><br> Results: The frequencies of HLA-DRB1*02<br/><br> (p=0.004), DRB1*14 (p=0.022), DQB1*0602<br/><br> (p=0.027), DQB1*0503 (p=0.022), were significantly<br/><br> increased in the whole group of patients<br/><br> with sarcoidosis as well as in sarcoidosis associated<br/><br> with autoimmune manifestations compared<br/><br> to healthy controls.<br/><br> Conclusions: Significant associations of HLADRB1*<br/><br> 02 and *14 and DQB1*0602 and *0503 with<br/><br> sarcoidosis were found, particularly apparent in<br/><br> the subgroup with associated autoimmune manifestations.<br/><br> Different immunogenetic profiles<br/><br> may thus exist in sarcoidosis indicative and/or<br/><br> causative of distinct clinical subgroups. HLA<br/><br> class II presentation of a putative sarcoidosisspecific<br/><br> antigen might be of vital importance in<br/><br> sarcoidosis, deciding the direction of the sarcoid<br/><br> disease and eventual associations with it.<br/><br> Whether the above mentioned HLA class II haplotypes<br/><br> and/or their linked genes, alone or in<br/><br> unison with HLA class I, are organ- or diseasespecific<br/><br> remains to be determined.}}, author = {{Papadopoulos, K I and Wassmuth, R and Sponsel, T and Sjöberg, K and Hallengren, Bengt}}, issn = {{1726-913X}}, keywords = {{Sarcoidosis; Thyroid; Polyglandular Autoimmune Syndromes; HLA; Autoimmunity}}, language = {{eng}}, number = {{1}}, pages = {{13--18}}, publisher = {{Iran Endocrine Society, Shaheed Beheshti University of Medical Sciences}}, series = {{International Journal of Endocrinology and Metabolism}}, title = {{Sarcoidosis and Autoimmunity: Evidence of Differential Associations with HLA Class II Markers}}, url = {{http://www.ijem.org/PDF/Vol4No1.pdf}}, volume = {{4}}, year = {{2006}}, }