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Relationship between pressure-volume curve and markers for collagen turn-over in early acute respiratory distress syndrome

Demoule, Alexandre ; Decailliot, Francois ; Jonson, Björn LU ; Christov, Christo ; Maitre, Bernard ; Touqui, Lhousseine ; Brochard, Laurent and Delclaux, Christophe (2006) In Intensive Care Medicine 32(3). p.413-420
Abstract
OBJECTIVE: In acute respiratory distress syndrome, the relationships between changes in the elastic behavior of the respiratory system and biological markers of extra-cellular matrix or surfactant turn-over could give some insights into its pathophysiological determinants. DESIGN AND MEASUREMENTS: In 17 patients with acute respiratory distress syndrome, we assessed the relationship between chord compliance measured on pressure-volume curves obtained at two levels of positive end-expiratory pressure (0 and 10[Symbol: see text]cm[Symbol: see text]H(2)O) and biological markers of collagen turn-over or surfactant degradation in bronchoalveolar lavage fluid obtained simultaneously in the early phase of the disease (first 4 days). MAIN RESULTS:... (More)
OBJECTIVE: In acute respiratory distress syndrome, the relationships between changes in the elastic behavior of the respiratory system and biological markers of extra-cellular matrix or surfactant turn-over could give some insights into its pathophysiological determinants. DESIGN AND MEASUREMENTS: In 17 patients with acute respiratory distress syndrome, we assessed the relationship between chord compliance measured on pressure-volume curves obtained at two levels of positive end-expiratory pressure (0 and 10[Symbol: see text]cm[Symbol: see text]H(2)O) and biological markers of collagen turn-over or surfactant degradation in bronchoalveolar lavage fluid obtained simultaneously in the early phase of the disease (first 4 days). MAIN RESULTS: The compliance of the respiratory system obtained from the pressure-volume curves was significantly correlated with markers for collagen turn-over (type III procollagen peptide and matrix metalloproteinase 2) and with markers of surfactant degradation (type-IIA secretory phospholipase A2). The correlations were stronger when the curve was traced from positive end-expiratory pressure, suggesting that this condition may improve the assessment of tissue mechanics. A logarithmic relationship best described the correlation between compliance and type III procollagen peptide, in agreement with a collagen-dependent model of maximal distension. The marker for surfactant degradation was associated with ongoing alveolar inflammation (cellularity of bronchoalveolar lavage fluid and tumor necrosis factor-alpha concentration). Interleukin-10, an anti-inflammatory mediator, showed no correlation with compliance. CONCLUSION: These preliminary data suggest that a severe reduction in compliance in the early phase of acute respiratory distress syndrome is associated with both collagen deposition and surfactant degradation. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Type III procollagen peptide, Matrix metalloproteinase-2, Type-IIA secretory phospholipase A2, Fibroproliferation, Acute respiratory distress syndrome, Compliance
in
Intensive Care Medicine
volume
32
issue
3
pages
413 - 420
publisher
Springer
external identifiers
  • pmid:16479381
  • scopus:33344456872
  • pmid:16479381
ISSN
0342-4642
DOI
10.1007/s00134-005-0043-z
language
English
LU publication?
yes
id
4d1af1c5-a3e5-4756-aaa4-90e51a00958d (old id 1137219)
date added to LUP
2016-04-01 11:52:28
date last changed
2022-01-26 19:31:38
@article{4d1af1c5-a3e5-4756-aaa4-90e51a00958d,
  abstract     = {{OBJECTIVE: In acute respiratory distress syndrome, the relationships between changes in the elastic behavior of the respiratory system and biological markers of extra-cellular matrix or surfactant turn-over could give some insights into its pathophysiological determinants. DESIGN AND MEASUREMENTS: In 17 patients with acute respiratory distress syndrome, we assessed the relationship between chord compliance measured on pressure-volume curves obtained at two levels of positive end-expiratory pressure (0 and 10[Symbol: see text]cm[Symbol: see text]H(2)O) and biological markers of collagen turn-over or surfactant degradation in bronchoalveolar lavage fluid obtained simultaneously in the early phase of the disease (first 4 days). MAIN RESULTS: The compliance of the respiratory system obtained from the pressure-volume curves was significantly correlated with markers for collagen turn-over (type III procollagen peptide and matrix metalloproteinase 2) and with markers of surfactant degradation (type-IIA secretory phospholipase A2). The correlations were stronger when the curve was traced from positive end-expiratory pressure, suggesting that this condition may improve the assessment of tissue mechanics. A logarithmic relationship best described the correlation between compliance and type III procollagen peptide, in agreement with a collagen-dependent model of maximal distension. The marker for surfactant degradation was associated with ongoing alveolar inflammation (cellularity of bronchoalveolar lavage fluid and tumor necrosis factor-alpha concentration). Interleukin-10, an anti-inflammatory mediator, showed no correlation with compliance. CONCLUSION: These preliminary data suggest that a severe reduction in compliance in the early phase of acute respiratory distress syndrome is associated with both collagen deposition and surfactant degradation.}},
  author       = {{Demoule, Alexandre and Decailliot, Francois and Jonson, Björn and Christov, Christo and Maitre, Bernard and Touqui, Lhousseine and Brochard, Laurent and Delclaux, Christophe}},
  issn         = {{0342-4642}},
  keywords     = {{Type III procollagen peptide; Matrix metalloproteinase-2; Type-IIA secretory phospholipase A2; Fibroproliferation; Acute respiratory distress syndrome; Compliance}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{413--420}},
  publisher    = {{Springer}},
  series       = {{Intensive Care Medicine}},
  title        = {{Relationship between pressure-volume curve and markers for collagen turn-over in early acute respiratory distress syndrome}},
  url          = {{http://dx.doi.org/10.1007/s00134-005-0043-z}},
  doi          = {{10.1007/s00134-005-0043-z}},
  volume       = {{32}},
  year         = {{2006}},
}