Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Relationship between pressure-volume curve and markers for collagen turn-over in early acute respiratory distress syndrome

Demoule, Alexandre ; Decailliot, Francois ; Jonson, Björn LU ; Christov, Christo ; Maitre, Bernard ; Touqui, Lhousseine ; Brochard, Laurent and Delclaux, Christophe (2006) In Intensive Care Medicine 32(3). p.413-420
Abstract
OBJECTIVE: In acute respiratory distress syndrome, the relationships between changes in the elastic behavior of the respiratory system and biological markers of extra-cellular matrix or surfactant turn-over could give some insights into its pathophysiological determinants. DESIGN AND MEASUREMENTS: In 17 patients with acute respiratory distress syndrome, we assessed the relationship between chord compliance measured on pressure-volume curves obtained at two levels of positive end-expiratory pressure (0 and 10[Symbol: see text]cm[Symbol: see text]H(2)O) and biological markers of collagen turn-over or surfactant degradation in bronchoalveolar lavage fluid obtained simultaneously in the early phase of the disease (first 4 days). MAIN RESULTS:... (More)
OBJECTIVE: In acute respiratory distress syndrome, the relationships between changes in the elastic behavior of the respiratory system and biological markers of extra-cellular matrix or surfactant turn-over could give some insights into its pathophysiological determinants. DESIGN AND MEASUREMENTS: In 17 patients with acute respiratory distress syndrome, we assessed the relationship between chord compliance measured on pressure-volume curves obtained at two levels of positive end-expiratory pressure (0 and 10[Symbol: see text]cm[Symbol: see text]H(2)O) and biological markers of collagen turn-over or surfactant degradation in bronchoalveolar lavage fluid obtained simultaneously in the early phase of the disease (first 4 days). MAIN RESULTS: The compliance of the respiratory system obtained from the pressure-volume curves was significantly correlated with markers for collagen turn-over (type III procollagen peptide and matrix metalloproteinase 2) and with markers of surfactant degradation (type-IIA secretory phospholipase A2). The correlations were stronger when the curve was traced from positive end-expiratory pressure, suggesting that this condition may improve the assessment of tissue mechanics. A logarithmic relationship best described the correlation between compliance and type III procollagen peptide, in agreement with a collagen-dependent model of maximal distension. The marker for surfactant degradation was associated with ongoing alveolar inflammation (cellularity of bronchoalveolar lavage fluid and tumor necrosis factor-alpha concentration). Interleukin-10, an anti-inflammatory mediator, showed no correlation with compliance. CONCLUSION: These preliminary data suggest that a severe reduction in compliance in the early phase of acute respiratory distress syndrome is associated with both collagen deposition and surfactant degradation. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Type III procollagen peptide, Matrix metalloproteinase-2, Type-IIA secretory phospholipase A2, Fibroproliferation, Acute respiratory distress syndrome, Compliance
in
Intensive Care Medicine
volume
32
issue
3
pages
413 - 420
publisher
Springer
external identifiers
  • pmid:16479381
  • scopus:33344456872
  • pmid:16479381
ISSN
0342-4642
DOI
10.1007/s00134-005-0043-z
language
English
LU publication?
yes
id
4d1af1c5-a3e5-4756-aaa4-90e51a00958d (old id 1137219)
date added to LUP
2016-04-01 11:52:28
date last changed
2020-11-22 05:41:19
@article{4d1af1c5-a3e5-4756-aaa4-90e51a00958d,
  abstract     = {OBJECTIVE: In acute respiratory distress syndrome, the relationships between changes in the elastic behavior of the respiratory system and biological markers of extra-cellular matrix or surfactant turn-over could give some insights into its pathophysiological determinants. DESIGN AND MEASUREMENTS: In 17 patients with acute respiratory distress syndrome, we assessed the relationship between chord compliance measured on pressure-volume curves obtained at two levels of positive end-expiratory pressure (0 and 10[Symbol: see text]cm[Symbol: see text]H(2)O) and biological markers of collagen turn-over or surfactant degradation in bronchoalveolar lavage fluid obtained simultaneously in the early phase of the disease (first 4 days). MAIN RESULTS: The compliance of the respiratory system obtained from the pressure-volume curves was significantly correlated with markers for collagen turn-over (type III procollagen peptide and matrix metalloproteinase 2) and with markers of surfactant degradation (type-IIA secretory phospholipase A2). The correlations were stronger when the curve was traced from positive end-expiratory pressure, suggesting that this condition may improve the assessment of tissue mechanics. A logarithmic relationship best described the correlation between compliance and type III procollagen peptide, in agreement with a collagen-dependent model of maximal distension. The marker for surfactant degradation was associated with ongoing alveolar inflammation (cellularity of bronchoalveolar lavage fluid and tumor necrosis factor-alpha concentration). Interleukin-10, an anti-inflammatory mediator, showed no correlation with compliance. CONCLUSION: These preliminary data suggest that a severe reduction in compliance in the early phase of acute respiratory distress syndrome is associated with both collagen deposition and surfactant degradation.},
  author       = {Demoule, Alexandre and Decailliot, Francois and Jonson, Björn and Christov, Christo and Maitre, Bernard and Touqui, Lhousseine and Brochard, Laurent and Delclaux, Christophe},
  issn         = {0342-4642},
  language     = {eng},
  number       = {3},
  pages        = {413--420},
  publisher    = {Springer},
  series       = {Intensive Care Medicine},
  title        = {Relationship between pressure-volume curve and markers for collagen turn-over in early acute respiratory distress syndrome},
  url          = {http://dx.doi.org/10.1007/s00134-005-0043-z},
  doi          = {10.1007/s00134-005-0043-z},
  volume       = {32},
  year         = {2006},
}