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Chlamydia pneumoniae infection: an additional factor for chronic allograft rejection.

Kwiatkowski, A.; Wszola, M.; Nosek, R.; Podsiadly, E.; Meszaros, J.; Ostrowski, K.; Lisik, W.; Michalak, G.; Chmura, A. and Kosieradzki, M., et al. (2006) In Transplantation Proceedings 38(1). p.108-111
Abstract
Introduction



Chronic rejection (CHR) of organ allografts, one of the most significant problems in modern transplantation, is not fully understood. This study sought to evaluate the influence of selected parameters on late kidney transplant function.

Patients and Method



The studied group consisted of eighty-six patients who received allogeneic transplants between 1988 and 1999 for leukocyte Chlamydia pneumoniae–DNA, immunoglobulin (Ig)A/IgG anti–C pneumoniae, blood lipids, ischemic damage in the donor and during organ preservation, HLA mismatch, and acute rejection episodes.

Results



Eighty-six patients were segregated as 26 patients (30%) with histologically proven... (More)
Introduction



Chronic rejection (CHR) of organ allografts, one of the most significant problems in modern transplantation, is not fully understood. This study sought to evaluate the influence of selected parameters on late kidney transplant function.

Patients and Method



The studied group consisted of eighty-six patients who received allogeneic transplants between 1988 and 1999 for leukocyte Chlamydia pneumoniae–DNA, immunoglobulin (Ig)A/IgG anti–C pneumoniae, blood lipids, ischemic damage in the donor and during organ preservation, HLA mismatch, and acute rejection episodes.

Results



Eighty-six patients were segregated as 26 patients (30%) with histologically proven chronic graft rejection (CHR[+]) and 59 patients (70%) without (CHR[−]). The presence of C pneumoniae–DNA in peripheral blood leukocytes was significantly more frequent in CHR(+) than CHR(−) group (46% vs 20%). Patients with leukocytes positive for C pneumoniae–DNA more frequently (50%) had CHR than patients negative for C pneumoniae–DNA (22%). CHR(+) patients showed significantly lower HDL levels (47 mg/dL vs 58 mg/dL) and higher triglyceride levels (193 mg/dL vs 148 mg/dL). To study the cumulative effect of differences between the CHR(+) and CHR(−) groups, we applied a multiple binary logistic regression analysis. An econometric model enabled us to calculate the probability of CHR for a given patient taking into account covariates chosen by means of stepwise selection: the presence of C pneumoniae–DNA in blood leukocytes, the use of continuous pulsatile perfusion in hypothermia, myocardial infarction occurrence, and triglyceride concentrations.

Conclusion



The presence of C pneumoniae–DNA in peripheral blood leukocytes increased the risk of CHR, which may be predicted by a multifactor analysis of chosen parameters. (Less)
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organization
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Contribution to journal
publication status
published
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in
Transplantation Proceedings
volume
38
issue
1
pages
108 - 111
publisher
Elsevier
external identifiers
  • Scopus:33644518706
ISSN
0041-1345
DOI
10.1016/j.transproceed.2005.12.036
language
English
LU publication?
yes
id
08ba259e-ffde-47e6-ad57-600df4585846 (old id 1137377)
date added to LUP
2008-06-11 11:32:29
date last changed
2017-01-01 08:01:20
@article{08ba259e-ffde-47e6-ad57-600df4585846,
  abstract     = {Introduction<br/><br>
<br/><br>
Chronic rejection (CHR) of organ allografts, one of the most significant problems in modern transplantation, is not fully understood. This study sought to evaluate the influence of selected parameters on late kidney transplant function.<br/><br>
Patients and Method<br/><br>
<br/><br>
The studied group consisted of eighty-six patients who received allogeneic transplants between 1988 and 1999 for leukocyte Chlamydia pneumoniae–DNA, immunoglobulin (Ig)A/IgG anti–C pneumoniae, blood lipids, ischemic damage in the donor and during organ preservation, HLA mismatch, and acute rejection episodes.<br/><br>
Results<br/><br>
<br/><br>
Eighty-six patients were segregated as 26 patients (30%) with histologically proven chronic graft rejection (CHR[+]) and 59 patients (70%) without (CHR[−]). The presence of C pneumoniae–DNA in peripheral blood leukocytes was significantly more frequent in CHR(+) than CHR(−) group (46% vs 20%). Patients with leukocytes positive for C pneumoniae–DNA more frequently (50%) had CHR than patients negative for C pneumoniae–DNA (22%). CHR(+) patients showed significantly lower HDL levels (47 mg/dL vs 58 mg/dL) and higher triglyceride levels (193 mg/dL vs 148 mg/dL). To study the cumulative effect of differences between the CHR(+) and CHR(−) groups, we applied a multiple binary logistic regression analysis. An econometric model enabled us to calculate the probability of CHR for a given patient taking into account covariates chosen by means of stepwise selection: the presence of C pneumoniae–DNA in blood leukocytes, the use of continuous pulsatile perfusion in hypothermia, myocardial infarction occurrence, and triglyceride concentrations.<br/><br>
Conclusion<br/><br>
<br/><br>
The presence of C pneumoniae–DNA in peripheral blood leukocytes increased the risk of CHR, which may be predicted by a multifactor analysis of chosen parameters.},
  author       = {Kwiatkowski, A. and Wszola, M. and Nosek, R. and Podsiadly, E. and Meszaros, J. and Ostrowski, K. and Lisik, W. and Michalak, G. and Chmura, A. and Kosieradzki, M. and Danielewicz, R. and Fesolowicz, S. and Kasprzyk, T. and Paczek, L. and Durlik, M. and Persson, Kenneth and Tylewska-Wierzbanowska, S},
  issn         = {0041-1345},
  language     = {eng},
  number       = {1},
  pages        = {108--111},
  publisher    = {Elsevier},
  series       = {Transplantation Proceedings},
  title        = {Chlamydia pneumoniae infection: an additional factor for chronic allograft rejection.},
  url          = {http://dx.doi.org/10.1016/j.transproceed.2005.12.036},
  volume       = {38},
  year         = {2006},
}