Advanced

Improved survival rate for women with interval breast cancer - results from the breast cancer screening programme in Malmo, Sweden 1976-1999

Zackrisson, Sophia LU ; Janzon, Lars LU ; Manjer, Jonas LU and Andersson, Ingvar LU (2007) In Journal of Medical Screening 14(3). p.138-143
Abstract
OBJECTIVE: Breast cancers detected between screening examinations can influence the sensitivity of a screening programme. Studies of the prognosis of these so-called interval breast cancers show diverging results. We investigated the course of interval breast cancer over time in the Malmo Mammographic Screening Trial (MMST) 1976-86 and the Malmo Mammographic Service Screening Programme (MMSSP) 1990-99. MATERIAL AND METHODS: Stage distribution and survival of interval cancers in MMSSP were compared with screen-detected and non-attender cancer cases in MMSSP, with interval cancers in MMST and with breast cancer cases in a non-screened population five years before the start of MMSSP (pre-screening cancer cases). RESULTS: In MMSSP 1990-99, the... (More)
OBJECTIVE: Breast cancers detected between screening examinations can influence the sensitivity of a screening programme. Studies of the prognosis of these so-called interval breast cancers show diverging results. We investigated the course of interval breast cancer over time in the Malmo Mammographic Screening Trial (MMST) 1976-86 and the Malmo Mammographic Service Screening Programme (MMSSP) 1990-99. MATERIAL AND METHODS: Stage distribution and survival of interval cancers in MMSSP were compared with screen-detected and non-attender cancer cases in MMSSP, with interval cancers in MMST and with breast cancer cases in a non-screened population five years before the start of MMSSP (pre-screening cancer cases). RESULTS: In MMSSP 1990-99, the interval cancers did not differ in stage distribution or survival compared with cancer cases in non-attenders, while screen-detected cancer cases had more favourable stage distribution and rate of survival than had the interval cancer cases. The MMST interval cancer cases, 1976-1986, had more favourable stage distribution but higher overall case fatality rate, relative risks (RR) 1.78 (1.00-3.20), and breast cancer case fatality rate, RR 2.05 (1.05-4.00), compared with the more recent MMSSP interval cancer cases. No significant difference in five-year survival was seen in the MMSSP interval cancer cases compared with pre-screening cancer cases not exposed to screening. CONCLUSION: In this urban population invited to mammographic screening, the survival rate for women with interval cancer has improved over a period of 20 years. Further studies are needed to assess what factors might explain changes in the course of interval breast cancer. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Medical Screening
volume
14
issue
3
pages
138 - 143
publisher
Royal Society of Medicine Press
external identifiers
  • pmid:17925086
  • wos:000251002100006
  • scopus:34848889948
ISSN
1475-5793
DOI
10.1258/096914107782066239
language
English
LU publication?
yes
id
ac0e13ea-a63e-4e37-9dc8-5bf1cda7733b (old id 1137792)
date added to LUP
2008-08-15 14:43:38
date last changed
2017-01-22 04:21:10
@article{ac0e13ea-a63e-4e37-9dc8-5bf1cda7733b,
  abstract     = {OBJECTIVE: Breast cancers detected between screening examinations can influence the sensitivity of a screening programme. Studies of the prognosis of these so-called interval breast cancers show diverging results. We investigated the course of interval breast cancer over time in the Malmo Mammographic Screening Trial (MMST) 1976-86 and the Malmo Mammographic Service Screening Programme (MMSSP) 1990-99. MATERIAL AND METHODS: Stage distribution and survival of interval cancers in MMSSP were compared with screen-detected and non-attender cancer cases in MMSSP, with interval cancers in MMST and with breast cancer cases in a non-screened population five years before the start of MMSSP (pre-screening cancer cases). RESULTS: In MMSSP 1990-99, the interval cancers did not differ in stage distribution or survival compared with cancer cases in non-attenders, while screen-detected cancer cases had more favourable stage distribution and rate of survival than had the interval cancer cases. The MMST interval cancer cases, 1976-1986, had more favourable stage distribution but higher overall case fatality rate, relative risks (RR) 1.78 (1.00-3.20), and breast cancer case fatality rate, RR 2.05 (1.05-4.00), compared with the more recent MMSSP interval cancer cases. No significant difference in five-year survival was seen in the MMSSP interval cancer cases compared with pre-screening cancer cases not exposed to screening. CONCLUSION: In this urban population invited to mammographic screening, the survival rate for women with interval cancer has improved over a period of 20 years. Further studies are needed to assess what factors might explain changes in the course of interval breast cancer.},
  author       = {Zackrisson, Sophia and Janzon, Lars and Manjer, Jonas and Andersson, Ingvar},
  issn         = {1475-5793},
  language     = {eng},
  number       = {3},
  pages        = {138--143},
  publisher    = {Royal Society of Medicine Press},
  series       = {Journal of Medical Screening},
  title        = {Improved survival rate for women with interval breast cancer - results from the breast cancer screening programme in Malmo, Sweden 1976-1999},
  url          = {http://dx.doi.org/10.1258/096914107782066239},
  volume       = {14},
  year         = {2007},
}