Advanced

Collagen antibody induced arthritis

Kutty Selva, Nandakumar LU and Holmdahl, Rikard LU (2007) In Methods in molecular medicine 136. p.215-223
Abstract
Rheumatoid arthritis (RA) is a polygenic and multifactorial disease. Many complex immunological and genetic interactions are involved in the final out come of the clinical disease. To understand the various disease pathways operating during the disease course, we need many different animal models. Collagen induced arthritis (CIA) is one of the widely used animal models sharing many pathological and histological similarities with RA and antibodies play an important role in the inflammatory phase of CIA. This chapter describes, in detail, an animal model for arthritis using CII specific monoclonal antibodies, the so-called collagen antibody induced arthritis (CAIA), which shares many characteristics of CIA. CAIA model provides an opportunity... (More)
Rheumatoid arthritis (RA) is a polygenic and multifactorial disease. Many complex immunological and genetic interactions are involved in the final out come of the clinical disease. To understand the various disease pathways operating during the disease course, we need many different animal models. Collagen induced arthritis (CIA) is one of the widely used animal models sharing many pathological and histological similarities with RA and antibodies play an important role in the inflammatory phase of CIA. This chapter describes, in detail, an animal model for arthritis using CII specific monoclonal antibodies, the so-called collagen antibody induced arthritis (CAIA), which shares many characteristics of CIA. CAIA model provides an opportunity to study the inflammatory phase of arthritis without involving the priming phase of the immune response. CAIA can be used for not only studying inflammatory processes in arthritis and screening drug candidates controlling joint inflammatory phase but also as a model for studying common mechanisms involved in many antibody mediated diseases. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Methods in molecular medicine
volume
136
pages
215 - 223
publisher
Humana Press
external identifiers
  • pmid:17983151
ISSN
1543-1894
DOI
10.1007/978-1-59745-402-5_16
language
English
LU publication?
yes
id
c9167e1d-1ada-46c4-9344-9144533787f3 (old id 1137872)
date added to LUP
2008-08-15 15:58:17
date last changed
2016-04-16 06:45:44
@article{c9167e1d-1ada-46c4-9344-9144533787f3,
  abstract     = {Rheumatoid arthritis (RA) is a polygenic and multifactorial disease. Many complex immunological and genetic interactions are involved in the final out come of the clinical disease. To understand the various disease pathways operating during the disease course, we need many different animal models. Collagen induced arthritis (CIA) is one of the widely used animal models sharing many pathological and histological similarities with RA and antibodies play an important role in the inflammatory phase of CIA. This chapter describes, in detail, an animal model for arthritis using CII specific monoclonal antibodies, the so-called collagen antibody induced arthritis (CAIA), which shares many characteristics of CIA. CAIA model provides an opportunity to study the inflammatory phase of arthritis without involving the priming phase of the immune response. CAIA can be used for not only studying inflammatory processes in arthritis and screening drug candidates controlling joint inflammatory phase but also as a model for studying common mechanisms involved in many antibody mediated diseases.},
  author       = {Kutty Selva, Nandakumar and Holmdahl, Rikard},
  issn         = {1543-1894},
  language     = {eng},
  pages        = {215--223},
  publisher    = {Humana Press},
  series       = {Methods in molecular medicine},
  title        = {Collagen antibody induced arthritis},
  url          = {http://dx.doi.org/10.1007/978-1-59745-402-5_16},
  volume       = {136},
  year         = {2007},
}