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Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection

Albiger, Barbara LU ; Dahlberg, Sofia; Sandgren, Andreas; Wartha, Florian; Beiter, Katharina; Katsuragi, Hiroaki; Akira, Shizuo; Normark, Staffan and Henriques-Normark, Birgitta (2007) In Cellular Microbiology 9(3). p.633-644
Abstract
Toll-like receptor 9 (TLR9) induces an inflammatory response by recognition of unmethylated CpG dinucleotides, mainly present in prokaryotic DNA. So far, TLR9-deficient mice have been shown to be more sensitive than wild-type mice to viral, but not to bacterial infections. Here, we show that mice deficient in TLR9 but not in TLR1, TLR2, TLR4 and TLR6 or IL-1R/IL-18R are more susceptible to a respiratory tract bacterial infection caused by Streptococcus pneumoniae. Intranasal challenge studies revealed that TLR9 plays a protective role in the lungs at an early stage of infection prior to the entry of circulating inflammatory cells. Alveolar as well as bone marrow-derived macrophages deficient in either TLR9 or the myeloid adaptor... (More)
Toll-like receptor 9 (TLR9) induces an inflammatory response by recognition of unmethylated CpG dinucleotides, mainly present in prokaryotic DNA. So far, TLR9-deficient mice have been shown to be more sensitive than wild-type mice to viral, but not to bacterial infections. Here, we show that mice deficient in TLR9 but not in TLR1, TLR2, TLR4 and TLR6 or IL-1R/IL-18R are more susceptible to a respiratory tract bacterial infection caused by Streptococcus pneumoniae. Intranasal challenge studies revealed that TLR9 plays a protective role in the lungs at an early stage of infection prior to the entry of circulating inflammatory cells. Alveolar as well as bone marrow-derived macrophages deficient in either TLR9 or the myeloid adaptor differentiation protein MyD88 were impaired in pneumococcal uptake and in pneumococcal killing. Our data suggest that in the airways, pneumococcal infection triggers a TLR9 and MyD88-dependent activation of phagocytic activity from resident macrophages leading to an early clearance of bacteria from the lower respiratory tract. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Cellular Microbiology
volume
9
issue
3
pages
633 - 644
publisher
Wiley-Blackwell
external identifiers
  • pmid:17004992
  • scopus:33846898975
ISSN
1462-5814
DOI
10.1111/j.1462-5822.2006.00814.x
language
English
LU publication?
no
id
abccc775-6792-428d-a53a-2c53664e5a56 (old id 1138107)
date added to LUP
2008-04-29 11:15:47
date last changed
2017-11-05 03:28:53
@article{abccc775-6792-428d-a53a-2c53664e5a56,
  abstract     = {Toll-like receptor 9 (TLR9) induces an inflammatory response by recognition of unmethylated CpG dinucleotides, mainly present in prokaryotic DNA. So far, TLR9-deficient mice have been shown to be more sensitive than wild-type mice to viral, but not to bacterial infections. Here, we show that mice deficient in TLR9 but not in TLR1, TLR2, TLR4 and TLR6 or IL-1R/IL-18R are more susceptible to a respiratory tract bacterial infection caused by Streptococcus pneumoniae. Intranasal challenge studies revealed that TLR9 plays a protective role in the lungs at an early stage of infection prior to the entry of circulating inflammatory cells. Alveolar as well as bone marrow-derived macrophages deficient in either TLR9 or the myeloid adaptor differentiation protein MyD88 were impaired in pneumococcal uptake and in pneumococcal killing. Our data suggest that in the airways, pneumococcal infection triggers a TLR9 and MyD88-dependent activation of phagocytic activity from resident macrophages leading to an early clearance of bacteria from the lower respiratory tract.},
  author       = {Albiger, Barbara and Dahlberg, Sofia and Sandgren, Andreas and Wartha, Florian and Beiter, Katharina and Katsuragi, Hiroaki and Akira, Shizuo and Normark, Staffan and Henriques-Normark, Birgitta},
  issn         = {1462-5814},
  language     = {eng},
  number       = {3},
  pages        = {633--644},
  publisher    = {Wiley-Blackwell},
  series       = {Cellular Microbiology},
  title        = {Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection},
  url          = {http://dx.doi.org/10.1111/j.1462-5822.2006.00814.x},
  volume       = {9},
  year         = {2007},
}