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Change in self-reported outcomes and objective physical function over 7 years in middle-aged subjects with or at high risk of knee osteoarthritis

Roos, Ewa LU ; Bremander, Ann LU ; Englund, Martin LU and Lohmander, Stefan LU (2008) In Annals of the Rheumatic Diseases 67(4). p.505-510
Abstract
OBJECTIVE: Describe the clinical course and predictors of change in self-reported outcomes and objectively assessed physical function over time in middle-aged subjects at high risk of, or with knee osteoarthritis (OA). METHODS: We examined 259 subjects (mean age 52.6 [SD 10.4]) at mean 18 and 25 years after previous meniscectomy and 50 population-based age- and sex-matched reference subjects with the Knee injury and Osteoarthritis Outcome Score (KOOS), one-leg hop for distance and number of knee-bendings in 30 seconds. Radiographic OA was defined as equivalent to Kellgren & Lawrence grade 2 or worse. RESULTS: At first assessment, meniscectomized subjects reported worse pain, function and quality of life compared with the reference... (More)
OBJECTIVE: Describe the clinical course and predictors of change in self-reported outcomes and objectively assessed physical function over time in middle-aged subjects at high risk of, or with knee osteoarthritis (OA). METHODS: We examined 259 subjects (mean age 52.6 [SD 10.4]) at mean 18 and 25 years after previous meniscectomy and 50 population-based age- and sex-matched reference subjects with the Knee injury and Osteoarthritis Outcome Score (KOOS), one-leg hop for distance and number of knee-bendings in 30 seconds. Radiographic OA was defined as equivalent to Kellgren & Lawrence grade 2 or worse. RESULTS: At first assessment, meniscectomized subjects reported worse pain, function and quality of life compared with the reference group (p<0.001). They also performed fewer knee-bendings per 30 sec (27 vs. 31, p=0.02). The meniscectomized patients worsened over the 4 to 10 year observation time in all measured outcomes (p<0.001), and to a greater extent than the reference group in pain (-5, 95% CI -10,0) and one-leg hop (-11, 95% CI -18,-3). Being a woman, or having radiographic knee OA, enhanced the worsening in both self-reported and objectively assessed outcomes. Older age and a higher BMI influenced objectively assessed physical function, but not self-reported outcomes. CONCLUSION: Worsening over time in knee-related pain and function is greater in meniscectomized subjects compared with reference subjects. Rehabilitative efforts may be warranted in middle-aged meniscectomized patients, especially in women and those who have developed radiographic knee OA, who are at greater risk of worsening. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
67
issue
4
pages
505 - 510
publisher
British Medical Association
external identifiers
  • pmid:17704069
  • wos:000254121100015
  • scopus:41849141644
ISSN
1468-2060
DOI
10.1136/ard.2007.074088
language
English
LU publication?
yes
id
1c49d0de-0a40-4644-8567-98ef320a1a03 (old id 1138203)
date added to LUP
2008-04-25 15:45:15
date last changed
2017-07-30 04:01:05
@article{1c49d0de-0a40-4644-8567-98ef320a1a03,
  abstract     = {OBJECTIVE: Describe the clinical course and predictors of change in self-reported outcomes and objectively assessed physical function over time in middle-aged subjects at high risk of, or with knee osteoarthritis (OA). METHODS: We examined 259 subjects (mean age 52.6 [SD 10.4]) at mean 18 and 25 years after previous meniscectomy and 50 population-based age- and sex-matched reference subjects with the Knee injury and Osteoarthritis Outcome Score (KOOS), one-leg hop for distance and number of knee-bendings in 30 seconds. Radiographic OA was defined as equivalent to Kellgren &amp; Lawrence grade 2 or worse. RESULTS: At first assessment, meniscectomized subjects reported worse pain, function and quality of life compared with the reference group (p&lt;0.001). They also performed fewer knee-bendings per 30 sec (27 vs. 31, p=0.02). The meniscectomized patients worsened over the 4 to 10 year observation time in all measured outcomes (p&lt;0.001), and to a greater extent than the reference group in pain (-5, 95% CI -10,0) and one-leg hop (-11, 95% CI -18,-3). Being a woman, or having radiographic knee OA, enhanced the worsening in both self-reported and objectively assessed outcomes. Older age and a higher BMI influenced objectively assessed physical function, but not self-reported outcomes. CONCLUSION: Worsening over time in knee-related pain and function is greater in meniscectomized subjects compared with reference subjects. Rehabilitative efforts may be warranted in middle-aged meniscectomized patients, especially in women and those who have developed radiographic knee OA, who are at greater risk of worsening.},
  author       = {Roos, Ewa and Bremander, Ann and Englund, Martin and Lohmander, Stefan},
  issn         = {1468-2060},
  language     = {eng},
  number       = {4},
  pages        = {505--510},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Change in self-reported outcomes and objective physical function over 7 years in middle-aged subjects with or at high risk of knee osteoarthritis},
  url          = {http://dx.doi.org/10.1136/ard.2007.074088},
  volume       = {67},
  year         = {2008},
}