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Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis

Marton, S; Garcia, MR; Robello, C; Persson, Helena LU ; Trajtenberg, F; Pritsch, O; Rovira, Carlos LU ; Naya, H; Dighiero, G and Cayota, A. (2008) In Leukemia 22(2). p.330-338
Abstract
MicroRNAs (miRNAs) are a novel class of small noncoding RNA molecules that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. There are more than 500 miRNA genes reported in the human genome, constituting one of the largest classes of regulatory genes. Increasing experimental evidence supports the idea of aberrant miRNA expression in cancer pathogenesis. We analyzed the pattern of miRNA expression in chronic lymphocytic leukemia (CLL) cells and our results showed a global reduction in miRNA expression levels in CLL cells associated to a consistent underexpression of miR-181a, let-7a and miR-30d. We observed overexpression of miR-155 and a set of five miRNAs that are differentially expressed... (More)
MicroRNAs (miRNAs) are a novel class of small noncoding RNA molecules that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. There are more than 500 miRNA genes reported in the human genome, constituting one of the largest classes of regulatory genes. Increasing experimental evidence supports the idea of aberrant miRNA expression in cancer pathogenesis. We analyzed the pattern of miRNA expression in chronic lymphocytic leukemia (CLL) cells and our results showed a global reduction in miRNA expression levels in CLL cells associated to a consistent underexpression of miR-181a, let-7a and miR-30d. We observed overexpression of miR-155 and a set of five miRNAs that are differentially expressed between patients with different clinical outcomes. Five novel miRNA candidates cloned from leukemic cells are reported. Surprisingly, predicted mRNA targets for these novel miRNA revealed a high proportion of targets located in a small region of chromosome (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Leukemia
volume
22
issue
2
pages
330 - 338
publisher
Nature Publishing Group
external identifiers
  • pmid:17989717
  • wos:000253166900014
  • scopus:39149134593
ISSN
1476-5551
DOI
10.1038/sj.leu.2405022
language
English
LU publication?
yes
id
c65a849e-d251-468f-a146-465602546368 (old id 1139432)
date added to LUP
2008-04-25 15:38:08
date last changed
2017-09-03 04:14:30
@article{c65a849e-d251-468f-a146-465602546368,
  abstract     = {MicroRNAs (miRNAs) are a novel class of small noncoding RNA molecules that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. There are more than 500 miRNA genes reported in the human genome, constituting one of the largest classes of regulatory genes. Increasing experimental evidence supports the idea of aberrant miRNA expression in cancer pathogenesis. We analyzed the pattern of miRNA expression in chronic lymphocytic leukemia (CLL) cells and our results showed a global reduction in miRNA expression levels in CLL cells associated to a consistent underexpression of miR-181a, let-7a and miR-30d. We observed overexpression of miR-155 and a set of five miRNAs that are differentially expressed between patients with different clinical outcomes. Five novel miRNA candidates cloned from leukemic cells are reported. Surprisingly, predicted mRNA targets for these novel miRNA revealed a high proportion of targets located in a small region of chromosome},
  author       = {Marton, S and Garcia, MR and Robello, C and Persson, Helena and Trajtenberg, F and Pritsch, O and Rovira, Carlos and Naya, H and Dighiero, G and Cayota, A.},
  issn         = {1476-5551},
  language     = {eng},
  number       = {2},
  pages        = {330--338},
  publisher    = {Nature Publishing Group},
  series       = {Leukemia},
  title        = {Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis},
  url          = {http://dx.doi.org/10.1038/sj.leu.2405022},
  volume       = {22},
  year         = {2008},
}