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Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L)

Bergman, Michael ; Manco, Melania ; Sesti, Giorgio ; Dankner, Rachel ; Pareek, Manan ; Jagannathan, Ram ; Chetrit, Angela ; Abdul-Ghani, Muhammad ; Buysschaert, Martin and Olsen, Michael H. , et al. (2018) In Diabetes Research and Clinical Practice 146. p.18-33
Abstract

Many individuals with prediabetes, as presently defined, will progress to diabetes (T2D) despite the considerable benefit of lifestyle modification. Therefore, it is paramount to screen individuals at increased risk with a more sensitive method capable of identifying prediabetes at an even earlier time point in the lengthy trajectory to T2D. This petition reviews findings demonstrating that the 1-hour (1-h) postload plasma glucose (PG) ≥ 155 mg/dl (8.6 mmol/L) in those with normal glucose tolerance (NGT) during an oral glucose tolerance test (OGTT) is highly predictive for detecting progression to T2D, micro- and macrovascular complications and mortality in individuals at increased risk. Furthermore, the STOP DIABETES Study documented... (More)

Many individuals with prediabetes, as presently defined, will progress to diabetes (T2D) despite the considerable benefit of lifestyle modification. Therefore, it is paramount to screen individuals at increased risk with a more sensitive method capable of identifying prediabetes at an even earlier time point in the lengthy trajectory to T2D. This petition reviews findings demonstrating that the 1-hour (1-h) postload plasma glucose (PG) ≥ 155 mg/dl (8.6 mmol/L) in those with normal glucose tolerance (NGT) during an oral glucose tolerance test (OGTT) is highly predictive for detecting progression to T2D, micro- and macrovascular complications and mortality in individuals at increased risk. Furthermore, the STOP DIABETES Study documented effective interventions that reduce the future risk of T2D in those with NGT and a 1-h PG ≥ 155 mg/dl (8·6 mmol/L). The 1-h OGTT represents a valuable opportunity to extend the proven benefit of diabetes prevention to the sizeable and growing population of individuals at increased risk of progression to T2D. The substantial evidence provided in this petition strongly supports redefining current diagnostic criteria for prediabetes with the elevated 1-h PG level. The authors therefore advocate a 1-h OGTT to detect prediabetes and hence, thwart the global diabetes epidemic.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diabetes, Dysglycemia, HbA, Impaired fasting glucose, Impaired glucose tolerance, Oral glucose tolerance test, Prediabetes
in
Diabetes Research and Clinical Practice
volume
146
pages
16 pages
publisher
Elsevier
external identifiers
  • pmid:30273707
  • scopus:85054423760
ISSN
0168-8227
DOI
10.1016/j.diabres.2018.09.017
language
English
LU publication?
yes
id
11394903-4d2e-4f0a-aa76-901d7add7861
date added to LUP
2018-10-29 13:38:01
date last changed
2024-04-15 15:15:56
@article{11394903-4d2e-4f0a-aa76-901d7add7861,
  abstract     = {{<p>Many individuals with prediabetes, as presently defined, will progress to diabetes (T2D) despite the considerable benefit of lifestyle modification. Therefore, it is paramount to screen individuals at increased risk with a more sensitive method capable of identifying prediabetes at an even earlier time point in the lengthy trajectory to T2D. This petition reviews findings demonstrating that the 1-hour (1-h) postload plasma glucose (PG) ≥ 155 mg/dl (8.6 mmol/L) in those with normal glucose tolerance (NGT) during an oral glucose tolerance test (OGTT) is highly predictive for detecting progression to T2D, micro- and macrovascular complications and mortality in individuals at increased risk. Furthermore, the STOP DIABETES Study documented effective interventions that reduce the future risk of T2D in those with NGT and a 1-h PG ≥ 155 mg/dl (8·6 mmol/L). The 1-h OGTT represents a valuable opportunity to extend the proven benefit of diabetes prevention to the sizeable and growing population of individuals at increased risk of progression to T2D. The substantial evidence provided in this petition strongly supports redefining current diagnostic criteria for prediabetes with the elevated 1-h PG level. The authors therefore advocate a 1-h OGTT to detect prediabetes and hence, thwart the global diabetes epidemic.</p>}},
  author       = {{Bergman, Michael and Manco, Melania and Sesti, Giorgio and Dankner, Rachel and Pareek, Manan and Jagannathan, Ram and Chetrit, Angela and Abdul-Ghani, Muhammad and Buysschaert, Martin and Olsen, Michael H. and Nilsson, Peter M. and Medina, José Luis and Roth, Jesse and Groop, Leif and del Prato, Stefano and Raz, Itamar and Ceriello, Antonio}},
  issn         = {{0168-8227}},
  keywords     = {{Diabetes; Dysglycemia; HbA; Impaired fasting glucose; Impaired glucose tolerance; Oral glucose tolerance test; Prediabetes}},
  language     = {{eng}},
  pages        = {{18--33}},
  publisher    = {{Elsevier}},
  series       = {{Diabetes Research and Clinical Practice}},
  title        = {{Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L)}},
  url          = {{http://dx.doi.org/10.1016/j.diabres.2018.09.017}},
  doi          = {{10.1016/j.diabres.2018.09.017}},
  volume       = {{146}},
  year         = {{2018}},
}