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Immunization for atherosclerosis

Chyu, Kuang-Yuh; Nilsson, Jan LU and Shah, Prediman K (2007) In Current Atherosclerosis Reports 9(2). p.104-109
Abstract
This review summarizes experimental findings that highlight the complex roles of the immune system in atherogenesis. Immune activation can have either proatherogenic or atheroprotective effects. Immune-modulation therapy via an active or passive immunization strategy aims to exploit the atheroprotective aspects of the immune system to modulate atherosclerosis. Several experimental studies have demonstrated that such an approach is feasible and effective, raising the tantalizing possibility that an atheroprotective vaccine can be developed for clinical testing. Several potential immunogens have been identified and tested for their atheroprotective efficacy with variable results. Although several questions such as choice of optimal antigens,... (More)
This review summarizes experimental findings that highlight the complex roles of the immune system in atherogenesis. Immune activation can have either proatherogenic or atheroprotective effects. Immune-modulation therapy via an active or passive immunization strategy aims to exploit the atheroprotective aspects of the immune system to modulate atherosclerosis. Several experimental studies have demonstrated that such an approach is feasible and effective, raising the tantalizing possibility that an atheroprotective vaccine can be developed for clinical testing. Several potential immunogens have been identified and tested for their atheroprotective efficacy with variable results. Although several questions such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects, and safety remain to be answered, we believe that a vaccine-based approach to manage atherosclerotic cardiovascular disease is a potentially viable paradigm. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Atherosclerosis Reports
volume
9
issue
2
pages
104 - 109
publisher
Current Medicine Group LLC
external identifiers
  • pmid:17877918
  • scopus:34548511332
ISSN
1523-3804
DOI
10.1007/s11883-007-0005-8
language
English
LU publication?
yes
id
763a4a20-a3fa-4a1f-9966-0739ee3ebfd7 (old id 1139806)
date added to LUP
2008-08-21 08:27:24
date last changed
2017-08-27 05:17:36
@article{763a4a20-a3fa-4a1f-9966-0739ee3ebfd7,
  abstract     = {This review summarizes experimental findings that highlight the complex roles of the immune system in atherogenesis. Immune activation can have either proatherogenic or atheroprotective effects. Immune-modulation therapy via an active or passive immunization strategy aims to exploit the atheroprotective aspects of the immune system to modulate atherosclerosis. Several experimental studies have demonstrated that such an approach is feasible and effective, raising the tantalizing possibility that an atheroprotective vaccine can be developed for clinical testing. Several potential immunogens have been identified and tested for their atheroprotective efficacy with variable results. Although several questions such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects, and safety remain to be answered, we believe that a vaccine-based approach to manage atherosclerotic cardiovascular disease is a potentially viable paradigm.},
  author       = {Chyu, Kuang-Yuh and Nilsson, Jan and Shah, Prediman K},
  issn         = {1523-3804},
  language     = {eng},
  number       = {2},
  pages        = {104--109},
  publisher    = {Current Medicine Group LLC},
  series       = {Current Atherosclerosis Reports},
  title        = {Immunization for atherosclerosis},
  url          = {http://dx.doi.org/10.1007/s11883-007-0005-8},
  volume       = {9},
  year         = {2007},
}