The impact of age and 24-h blood pressure on arterial health in acute ischemic stroke patients : The Norwegian stroke in the young study
(2021) In Journal of Clinical Hypertension 23(10). p.1922-1929- Abstract
The impact of age and 24-h ambulatory blood pressure (ABPM) on arterial stiffness and carotid intima-media thickness (cIMT) in ischemic stroke patients younger than 60 years of age is poorly explored. A total of 385 acute ischemic stroke patients (aged 49.6±9.7 years, 68% men) were prospectively included and grouped in younger (15–44 years, n = 93) and middle-aged (45–60 years, n = 292). Arterial stiffness was measured by carotid-femoral pulse wave velocity (PWV), and cIMT by carotid ultrasound. 24-h ABPM was recorded. The middle-aged stroke patients had higher prevalence of smoking, hypertension, diabetes mellitus, metabolic syndrome and hypercholesterolemia, and had higher PWV and cIMT (all p <.05). In multivariable linear... (More)
The impact of age and 24-h ambulatory blood pressure (ABPM) on arterial stiffness and carotid intima-media thickness (cIMT) in ischemic stroke patients younger than 60 years of age is poorly explored. A total of 385 acute ischemic stroke patients (aged 49.6±9.7 years, 68% men) were prospectively included and grouped in younger (15–44 years, n = 93) and middle-aged (45–60 years, n = 292). Arterial stiffness was measured by carotid-femoral pulse wave velocity (PWV), and cIMT by carotid ultrasound. 24-h ABPM was recorded. The middle-aged stroke patients had higher prevalence of smoking, hypertension, diabetes mellitus, metabolic syndrome and hypercholesterolemia, and had higher PWV and cIMT (all p <.05). In multivariable linear regression analyses adjusted for sex, BMI, smoking, diabetes mellitus, total cholesterol, high-density lipoprotein cholesterol, triglycerides, eGFR, systolic BP and concomitant antihypertensive treatment, 1SD (4.4 years) higher age was associated with higher PWV (β = 0.44,R2= 0.46, p <.001) in the younger group, and with higher mean cIMT (β = 0.16, R2= 0.21, p =.01) in the middle-aged group. In the middle-aged group, 24-h pulse pressure had a significant association with PWV (β = 0.18, R2= 0.19, p =.009), while the association with cIMT was attenuated (β = 0.13, R2= 0.16, p =.065). 24-h diastolic BP was associated with higher cIMT in the middle-aged group (β = 0.24, p <.001, R2= 0.23), but not with PWV in either age groups. Among ischemic stroke patients < 60 years, higher age was associated with increased arterial stiffness for patients up to age 44 years, and with cIMT in middle-aged patients. 24-h pulse pressure was associated with arterial stiffness, and 24-h diastolic BP was associated with cIMT only in middle-aged patients.
(Less)
- author
- Saeed, Sahrai ; Waje-Andreassen, Ulrike ; Naess, Halvor ; Fromm, Annette and Nilsson, Peter M. LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- age, ambulatory blood pressure, arterial stiffness, carotid intima-media thickness, hypertension, ischemic stroke, pulse pressure, pulse wave velocity
- in
- Journal of Clinical Hypertension
- volume
- 23
- issue
- 10
- pages
- 1922 - 1929
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85114317293
- pmid:34492149
- ISSN
- 1524-6175
- DOI
- 10.1111/jch.14361
- language
- English
- LU publication?
- yes
- id
- 113cb074-ae8a-4894-8712-97a50b5963c9
- date added to LUP
- 2021-10-05 14:42:11
- date last changed
- 2025-01-13 14:30:37
@article{113cb074-ae8a-4894-8712-97a50b5963c9,
abstract = {{<p>The impact of age and 24-h ambulatory blood pressure (ABPM) on arterial stiffness and carotid intima-media thickness (cIMT) in ischemic stroke patients younger than 60 years of age is poorly explored. A total of 385 acute ischemic stroke patients (aged 49.6±9.7 years, 68% men) were prospectively included and grouped in younger (15–44 years, n = 93) and middle-aged (45–60 years, n = 292). Arterial stiffness was measured by carotid-femoral pulse wave velocity (PWV), and cIMT by carotid ultrasound. 24-h ABPM was recorded. The middle-aged stroke patients had higher prevalence of smoking, hypertension, diabetes mellitus, metabolic syndrome and hypercholesterolemia, and had higher PWV and cIMT (all p <.05). In multivariable linear regression analyses adjusted for sex, BMI, smoking, diabetes mellitus, total cholesterol, high-density lipoprotein cholesterol, triglycerides, eGFR, systolic BP and concomitant antihypertensive treatment, 1SD (4.4 years) higher age was associated with higher PWV (β = 0.44,R<sup>2</sup>= 0.46, p <.001) in the younger group, and with higher mean cIMT (β = 0.16, R<sup>2</sup>= 0.21, p =.01) in the middle-aged group. In the middle-aged group, 24-h pulse pressure had a significant association with PWV (β = 0.18, R<sup>2</sup>= 0.19, p =.009), while the association with cIMT was attenuated (β = 0.13, R<sup>2</sup>= 0.16, p =.065). 24-h diastolic BP was associated with higher cIMT in the middle-aged group (β = 0.24, p <.001, R<sup>2</sup>= 0.23), but not with PWV in either age groups. Among ischemic stroke patients < 60 years, higher age was associated with increased arterial stiffness for patients up to age 44 years, and with cIMT in middle-aged patients. 24-h pulse pressure was associated with arterial stiffness, and 24-h diastolic BP was associated with cIMT only in middle-aged patients.</p>}},
author = {{Saeed, Sahrai and Waje-Andreassen, Ulrike and Naess, Halvor and Fromm, Annette and Nilsson, Peter M.}},
issn = {{1524-6175}},
keywords = {{age; ambulatory blood pressure; arterial stiffness; carotid intima-media thickness; hypertension; ischemic stroke; pulse pressure; pulse wave velocity}},
language = {{eng}},
number = {{10}},
pages = {{1922--1929}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Clinical Hypertension}},
title = {{The impact of age and 24-h blood pressure on arterial health in acute ischemic stroke patients : The Norwegian stroke in the young study}},
url = {{http://dx.doi.org/10.1111/jch.14361}},
doi = {{10.1111/jch.14361}},
volume = {{23}},
year = {{2021}},
}