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Comparison of echocardiographic and cardiac magnetic resonance imaging for assessing right ventricular function in adults with repaired tetralogy of fallot

Schwerzmann, Markus; Samman, Ahmed M; Salehian, Omid; Holm, Johan LU ; Provost, Yves; Webb, Gary D; Therrien, Judith; Siu, Samuel C and Silversides, Candice K (2007) In American Journal of Cardiology 99(11). p.1593-1597
Abstract
Adults with repaired tetralogy of Fallot and significant chronic pulmonary regurgitation are at risk for progressive right ventricular (RV) dilatation and dysfunction. The assessment of RV function is important in the management in these patients. There is still a lack of an adequate geometric model to quantify RV function by echocardiography. The myocardial performance index (MPI) is a nonvolumetric method to quantify global ventricular function. In this study, the accuracy of MPI obtained by echocardiography to quantify RV function was assessed in 57 adults with repaired tetralogy of Fallot. The MPI measurement was compared with the RV ejection fraction (EF) derived by cardiac magnetic resonance imaging. There was a negative linear... (More)
Adults with repaired tetralogy of Fallot and significant chronic pulmonary regurgitation are at risk for progressive right ventricular (RV) dilatation and dysfunction. The assessment of RV function is important in the management in these patients. There is still a lack of an adequate geometric model to quantify RV function by echocardiography. The myocardial performance index (MPI) is a nonvolumetric method to quantify global ventricular function. In this study, the accuracy of MPI obtained by echocardiography to quantify RV function was assessed in 57 adults with repaired tetralogy of Fallot. The MPI measurement was compared with the RV ejection fraction (EF) derived by cardiac magnetic resonance imaging. There was a negative linear correlation between the MPI and the RVEF (r = 0.73, p <0.001). A MPI cutoff of > or =0.40 had a sensitivity of 81% and a specificity of 85% to diagnose a RVEF <35%. A MPI cutoff of <0.25 had a sensitivity of 70% and a specificity of 89% to identify patients with RVEFs > or =0.50. In a multivariate regression model, the MPI was not affected by the degree of pulmonary regurgitation, the presence of tricuspid regurgitation, or the QRS duration. In conclusion, the Doppler-derived MPI is a simple and reliable method for the evaluation of RV systolic function in adults with repaired tetralogy of Fallot. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Cardiology
volume
99
issue
11
pages
1593 - 1597
publisher
Excerpta Medica
external identifiers
  • pmid:17531587
  • scopus:34248666730
ISSN
1879-1913
DOI
10.1016/j.amjcard.2007.01.035
language
English
LU publication?
no
id
6fddadd5-9249-4ace-a7a1-b15956fd6edb (old id 1140153)
date added to LUP
2008-08-21 13:59:53
date last changed
2017-11-19 03:24:57
@article{6fddadd5-9249-4ace-a7a1-b15956fd6edb,
  abstract     = {Adults with repaired tetralogy of Fallot and significant chronic pulmonary regurgitation are at risk for progressive right ventricular (RV) dilatation and dysfunction. The assessment of RV function is important in the management in these patients. There is still a lack of an adequate geometric model to quantify RV function by echocardiography. The myocardial performance index (MPI) is a nonvolumetric method to quantify global ventricular function. In this study, the accuracy of MPI obtained by echocardiography to quantify RV function was assessed in 57 adults with repaired tetralogy of Fallot. The MPI measurement was compared with the RV ejection fraction (EF) derived by cardiac magnetic resonance imaging. There was a negative linear correlation between the MPI and the RVEF (r = 0.73, p &lt;0.001). A MPI cutoff of &gt; or =0.40 had a sensitivity of 81% and a specificity of 85% to diagnose a RVEF &lt;35%. A MPI cutoff of &lt;0.25 had a sensitivity of 70% and a specificity of 89% to identify patients with RVEFs &gt; or =0.50. In a multivariate regression model, the MPI was not affected by the degree of pulmonary regurgitation, the presence of tricuspid regurgitation, or the QRS duration. In conclusion, the Doppler-derived MPI is a simple and reliable method for the evaluation of RV systolic function in adults with repaired tetralogy of Fallot.},
  author       = {Schwerzmann, Markus and Samman, Ahmed M and Salehian, Omid and Holm, Johan and Provost, Yves and Webb, Gary D and Therrien, Judith and Siu, Samuel C and Silversides, Candice K},
  issn         = {1879-1913},
  language     = {eng},
  number       = {11},
  pages        = {1593--1597},
  publisher    = {Excerpta Medica},
  series       = {American Journal of Cardiology},
  title        = {Comparison of echocardiographic and cardiac magnetic resonance imaging for assessing right ventricular function in adults with repaired tetralogy of fallot},
  url          = {http://dx.doi.org/10.1016/j.amjcard.2007.01.035},
  volume       = {99},
  year         = {2007},
}