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Akut leversvikt ­- viktigt med snabb multidisciplinär handläggning

Bjornsson, Einar; Wei, Gu; Bergquist, Annika; Broome, Ulrika; Wallerstedt, Sven; Almer, Sven; Sangfelt, Per; Danielsson, Ake; Sandberg-Gertzen, Hanna and Loof, Lars, et al. (2007) In Läkartidningen 104(4). p.210-213
Abstract (Swedish)
En sammanställning av etiologin till akut leversvikt hos patienter i Sverige 1994–2003 visade att paracetamolförgiftningar (42 procent) och idiosynkratisk,

läkemedelsinducerad leverskada (15 procent) var de vanligaste orsakerna. Prognosen varierade stort beroende på etiologin. Sammanlagt 13 procent av patienterna med paracetamolförgiftning avled, och 5 procent

transplanterades. Av patienterna med akut leversvikt orsakad av idiosynkratisk, läkemedelsinducerad leverskada

transplanterades 49 procent. Det är viktigt med snabb utredning av patienter med akut leversvikt, eftersom prognosen avgörs av etiologin. Det är även av betydelse att ta kontakt med ett transplantationscentrum tidigt. Patienter med svår leversvikt... (More)
En sammanställning av etiologin till akut leversvikt hos patienter i Sverige 1994–2003 visade att paracetamolförgiftningar (42 procent) och idiosynkratisk,

läkemedelsinducerad leverskada (15 procent) var de vanligaste orsakerna. Prognosen varierade stort beroende på etiologin. Sammanlagt 13 procent av patienterna med paracetamolförgiftning avled, och 5 procent

transplanterades. Av patienterna med akut leversvikt orsakad av idiosynkratisk, läkemedelsinducerad leverskada

transplanterades 49 procent. Det är viktigt med snabb utredning av patienter med akut leversvikt, eftersom prognosen avgörs av etiologin. Det är även av betydelse att ta kontakt med ett transplantationscentrum tidigt. Patienter med svår leversvikt kräver ett multidisciplinärt

omhändertagande med samarbete mellan hepatologer, intensivvårdsläkare och transplantationskirurger. (Less)
Abstract
A recent study in Sweden on patients with acute liver failure (ALF) 1994-2003 demonstrated that the most common causes were paracetamol toxicity (42%) and idiosyncratic drug reactions (15%). In 11% of cases of ALF no definite etiology could be established. Among patients with paracetamol toxicity, the spontaneous survival without liver transplantation was 82% compared to 49% in patients with reactions to other drugs and 29% among the patients with indeterminate cause. Patients with ALF need a rapid and effective diagnostic work-up to detect the etiology as this often determines the outcome. In ALF it is of major importance to make an early contact with a transplant centre as the search for a suitable donor organ may take time in patients... (More)
A recent study in Sweden on patients with acute liver failure (ALF) 1994-2003 demonstrated that the most common causes were paracetamol toxicity (42%) and idiosyncratic drug reactions (15%). In 11% of cases of ALF no definite etiology could be established. Among patients with paracetamol toxicity, the spontaneous survival without liver transplantation was 82% compared to 49% in patients with reactions to other drugs and 29% among the patients with indeterminate cause. Patients with ALF need a rapid and effective diagnostic work-up to detect the etiology as this often determines the outcome. In ALF it is of major importance to make an early contact with a transplant centre as the search for a suitable donor organ may take time in patients who are candidates for a liver transplantation. Patients with acute liver failure need a multidisciplinary care with co-operation between hepatologists, intensive care unit specialists and transplant surgeons. (Less)
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author
, et al. (More)
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organization
alternative title
Acute liver failure--rapid multidisciplinary management
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Akut leversvikt
in
Läkartidningen
volume
104
issue
4
pages
210 - 213
external identifiers
  • pmid:17328461
  • scopus:33846811515
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
d0b21947-6fb8-46d4-807f-d91bfd243a9a (old id 1140239)
alternative location
http://ltarkiv.lakartidningen.se/artNo32873
date added to LUP
2008-08-21 14:50:43
date last changed
2017-01-01 06:56:53
@article{d0b21947-6fb8-46d4-807f-d91bfd243a9a,
  abstract     = {A recent study in Sweden on patients with acute liver failure (ALF) 1994-2003 demonstrated that the most common causes were paracetamol toxicity (42%) and idiosyncratic drug reactions (15%). In 11% of cases of ALF no definite etiology could be established. Among patients with paracetamol toxicity, the spontaneous survival without liver transplantation was 82% compared to 49% in patients with reactions to other drugs and 29% among the patients with indeterminate cause. Patients with ALF need a rapid and effective diagnostic work-up to detect the etiology as this often determines the outcome. In ALF it is of major importance to make an early contact with a transplant centre as the search for a suitable donor organ may take time in patients who are candidates for a liver transplantation. Patients with acute liver failure need a multidisciplinary care with co-operation between hepatologists, intensive care unit specialists and transplant surgeons.},
  author       = {Bjornsson, Einar and Wei, Gu and Bergquist, Annika and Broome, Ulrika and Wallerstedt, Sven and Almer, Sven and Sangfelt, Per and Danielsson, Ake and Sandberg-Gertzen, Hanna and Loof, Lars and Prytz, Hanne and Lindgren, Stefan},
  issn         = {0023-7205},
  keyword      = {Akut leversvikt},
  language     = {swe},
  number       = {4},
  pages        = {210--213},
  series       = {Läkartidningen},
  title        = {Akut leversvikt ­- viktigt med snabb multidisciplinär handläggning},
  volume       = {104},
  year         = {2007},
}