Akut leversvikt - viktigt med snabb multidisciplinär handläggning
(2007) In Läkartidningen 104(4). p.210-213- Abstract
- A recent study in Sweden on patients with acute liver failure (ALF) 1994-2003 demonstrated that the most common causes were paracetamol toxicity (42%) and idiosyncratic drug reactions (15%). In 11% of cases of ALF no definite etiology could be established. Among patients with paracetamol toxicity, the spontaneous survival without liver transplantation was 82% compared to 49% in patients with reactions to other drugs and 29% among the patients with indeterminate cause. Patients with ALF need a rapid and effective diagnostic work-up to detect the etiology as this often determines the outcome. In ALF it is of major importance to make an early contact with a transplant centre as the search for a suitable donor organ may take time in patients... (More)
- A recent study in Sweden on patients with acute liver failure (ALF) 1994-2003 demonstrated that the most common causes were paracetamol toxicity (42%) and idiosyncratic drug reactions (15%). In 11% of cases of ALF no definite etiology could be established. Among patients with paracetamol toxicity, the spontaneous survival without liver transplantation was 82% compared to 49% in patients with reactions to other drugs and 29% among the patients with indeterminate cause. Patients with ALF need a rapid and effective diagnostic work-up to detect the etiology as this often determines the outcome. In ALF it is of major importance to make an early contact with a transplant centre as the search for a suitable donor organ may take time in patients who are candidates for a liver transplantation. Patients with acute liver failure need a multidisciplinary care with co-operation between hepatologists, intensive care unit specialists and transplant surgeons. (Less)
- Abstract (Swedish)
- En sammanställning av etiologin till akut leversvikt hos patienter i Sverige 1994–2003 visade att paracetamolförgiftningar (42 procent) och idiosynkratisk,
läkemedelsinducerad leverskada (15 procent) var de vanligaste orsakerna. Prognosen varierade stort beroende på etiologin. Sammanlagt 13 procent av patienterna med paracetamolförgiftning avled, och 5 procent
transplanterades. Av patienterna med akut leversvikt orsakad av idiosynkratisk, läkemedelsinducerad leverskada
transplanterades 49 procent. Det är viktigt med snabb utredning av patienter med akut leversvikt, eftersom prognosen avgörs av etiologin. Det är även av betydelse att ta kontakt med ett transplantationscentrum tidigt. Patienter med svår leversvikt... (More) - En sammanställning av etiologin till akut leversvikt hos patienter i Sverige 1994–2003 visade att paracetamolförgiftningar (42 procent) och idiosynkratisk,
läkemedelsinducerad leverskada (15 procent) var de vanligaste orsakerna. Prognosen varierade stort beroende på etiologin. Sammanlagt 13 procent av patienterna med paracetamolförgiftning avled, och 5 procent
transplanterades. Av patienterna med akut leversvikt orsakad av idiosynkratisk, läkemedelsinducerad leverskada
transplanterades 49 procent. Det är viktigt med snabb utredning av patienter med akut leversvikt, eftersom prognosen avgörs av etiologin. Det är även av betydelse att ta kontakt med ett transplantationscentrum tidigt. Patienter med svår leversvikt kräver ett multidisciplinärt
omhändertagande med samarbete mellan hepatologer, intensivvårdsläkare och transplantationskirurger. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1140239
- author
- organization
- alternative title
- Acute liver failure--rapid multidisciplinary management
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Akut leversvikt
- in
- Läkartidningen
- volume
- 104
- issue
- 4
- pages
- 210 - 213
- publisher
- Swedish Medical Association
- external identifiers
-
- pmid:17328461
- scopus:33846811515
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- d0b21947-6fb8-46d4-807f-d91bfd243a9a (old id 1140239)
- alternative location
- http://ltarkiv.lakartidningen.se/artNo32873
- date added to LUP
- 2016-04-01 16:08:35
- date last changed
- 2024-10-11 15:15:39
@article{d0b21947-6fb8-46d4-807f-d91bfd243a9a,
abstract = {{A recent study in Sweden on patients with acute liver failure (ALF) 1994-2003 demonstrated that the most common causes were paracetamol toxicity (42%) and idiosyncratic drug reactions (15%). In 11% of cases of ALF no definite etiology could be established. Among patients with paracetamol toxicity, the spontaneous survival without liver transplantation was 82% compared to 49% in patients with reactions to other drugs and 29% among the patients with indeterminate cause. Patients with ALF need a rapid and effective diagnostic work-up to detect the etiology as this often determines the outcome. In ALF it is of major importance to make an early contact with a transplant centre as the search for a suitable donor organ may take time in patients who are candidates for a liver transplantation. Patients with acute liver failure need a multidisciplinary care with co-operation between hepatologists, intensive care unit specialists and transplant surgeons.}},
author = {{Bjornsson, Einar and Wei, Gu and Bergquist, Annika and Broome, Ulrika and Wallerstedt, Sven and Almer, Sven and Sangfelt, Per and Danielsson, Ake and Sandberg-Gertzen, Hanna and Loof, Lars and Prytz, Hanne and Lindgren, Stefan}},
issn = {{0023-7205}},
keywords = {{Akut leversvikt}},
language = {{swe}},
number = {{4}},
pages = {{210--213}},
publisher = {{Swedish Medical Association}},
series = {{Läkartidningen}},
title = {{Akut leversvikt - viktigt med snabb multidisciplinär handläggning}},
url = {{http://ltarkiv.lakartidningen.se/artNo32873}},
volume = {{104}},
year = {{2007}},
}