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Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension

Curtis, Maurice A; Kam, Monica; Nannmark, Ulf; Anderson, Michelle F; Axell, Mathilda Zetterstrom; Wikkelso, Carsten; Holtås, Stig LU ; van Roon-Mom, Willeke M C; Bjork-Eriksson, Thomas and Nordborg, Claes, et al. (2007) In Science (New York, N.Y.) 315(5816). p.1243-1249
Abstract
The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
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type
Contribution to journal
publication status
published
subject
in
Science (New York, N.Y.)
volume
315
issue
5816
pages
1243 - 1249
publisher
The American Association for the Advancement of Science
external identifiers
  • pmid:17303719
  • scopus:33847629581
ISSN
1095-9203
DOI
10.1126/science.1136281
language
English
LU publication?
yes
id
070e0fde-9499-4aa0-9827-e8bd6baba129 (old id 1140552)
date added to LUP
2008-08-15 09:12:57
date last changed
2017-04-23 04:38:33
@article{070e0fde-9499-4aa0-9827-e8bd6baba129,
  abstract     = {The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.},
  author       = {Curtis, Maurice A and Kam, Monica and Nannmark, Ulf and Anderson, Michelle F and Axell, Mathilda Zetterstrom and Wikkelso, Carsten and Holtås, Stig and van Roon-Mom, Willeke M C and Bjork-Eriksson, Thomas and Nordborg, Claes and Frisen, Jonas and Dragunow, Michael and Faull, Rich},
  issn         = {1095-9203},
  language     = {eng},
  number       = {5816},
  pages        = {1243--1249},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science (New York, N.Y.)},
  title        = {Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension},
  url          = {http://dx.doi.org/10.1126/science.1136281},
  volume       = {315},
  year         = {2007},
}