Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension
(2007) In Science (New York, N.Y.) 315(5816). p.1243-1249- Abstract
- The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1140552
- author
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science (New York, N.Y.)
- volume
- 315
- issue
- 5816
- pages
- 1243 - 1249
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:17303719
- scopus:33847629581
- pmid:17303719
- ISSN
- 1095-9203
- DOI
- 10.1126/science.1136281
- language
- English
- LU publication?
- yes
- id
- 070e0fde-9499-4aa0-9827-e8bd6baba129 (old id 1140552)
- date added to LUP
- 2016-04-04 09:21:09
- date last changed
- 2022-04-23 20:13:07
@article{070e0fde-9499-4aa0-9827-e8bd6baba129, abstract = {{The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.}}, author = {{Curtis, Maurice A and Kam, Monica and Nannmark, Ulf and Anderson, Michelle F and Axell, Mathilda Zetterstrom and Wikkelso, Carsten and Holtås, Stig and van Roon-Mom, Willeke M C and Bjork-Eriksson, Thomas and Nordborg, Claes and Frisen, Jonas and Dragunow, Michael and Faull, Rich}}, issn = {{1095-9203}}, language = {{eng}}, number = {{5816}}, pages = {{1243--1249}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science (New York, N.Y.)}}, title = {{Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension}}, url = {{http://dx.doi.org/10.1126/science.1136281}}, doi = {{10.1126/science.1136281}}, volume = {{315}}, year = {{2007}}, }