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Fria radikaler och sjuka proteiner - bovarna bakom Parkinsons sjukdom?[Free radicals and ailing proteins - the culprits behind Parkinson’s disease?]

Smith, Ruben LU ; Lotharius, Julie LU and Brundin, Patrik LU (2003) In Läkartidningen 100(15). p.6-1329
Abstract
Parkinson’s disease is one of the most common neurodegenerative diseases, and affects approximately 1% of the population over 65 years of age. Many different insults appear to be involved in the etiology of the disease, among them environmental toxins and mitochondrial dysfunction. During the past five years, mutations in five different genes have been linked to rare, familial forms of Parkinson’s disease. One of the mutated proteins, a-synuclein is normally implicated in synaptic plasticity and vesicle function. Dysfunction of this protein might lead to increased cytoplasmic dopamine

levels. Since cytoplasmic dopamine is readily

prone to autooxidation and enzymatic degradation - processes which generate reactive oxygen... (More)
Parkinson’s disease is one of the most common neurodegenerative diseases, and affects approximately 1% of the population over 65 years of age. Many different insults appear to be involved in the etiology of the disease, among them environmental toxins and mitochondrial dysfunction. During the past five years, mutations in five different genes have been linked to rare, familial forms of Parkinson’s disease. One of the mutated proteins, a-synuclein is normally implicated in synaptic plasticity and vesicle function. Dysfunction of this protein might lead to increased cytoplasmic dopamine

levels. Since cytoplasmic dopamine is readily

prone to autooxidation and enzymatic degradation - processes which generate reactive oxygen species - failure to properly store dopamine into vesicles might lead to oxidative stress. Indeed, nigral tissue from idiopathic Parkinson’s disease patients shows signs of oxidative damage. In this article we propose that dopamine-induced oxidative stress might be a common final pathway in the pathogenesis of the disease. (Less)
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author
organization
alternative title
Free radicals and ailing proteins- the culprits behind Parkinson’s disease?
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
100
issue
15
pages
6 - 1329
publisher
Swedish Medical Association
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
7592ff0c-a7ef-4218-93dc-c3d9cd08f517 (old id 114120)
alternative location
http://ltarkiv.lakartidningen.se/artNo26514
date added to LUP
2007-07-19 14:12:10
date last changed
2018-05-29 10:40:47
@article{7592ff0c-a7ef-4218-93dc-c3d9cd08f517,
  abstract     = {Parkinson’s disease is one of the most common neurodegenerative diseases, and affects approximately 1% of the population over 65 years of age. Many different insults appear to be involved in the etiology of the disease, among them environmental toxins and mitochondrial dysfunction. During the past five years, mutations in five different genes have been linked to rare, familial forms of Parkinson’s disease. One of the mutated proteins, a-synuclein is normally implicated in synaptic plasticity and vesicle function. Dysfunction of this protein might lead to increased cytoplasmic dopamine<br/><br>
levels. Since cytoplasmic dopamine is readily<br/><br>
prone to autooxidation and enzymatic degradation - processes which generate reactive oxygen species - failure to properly store dopamine into vesicles might lead to oxidative stress. Indeed, nigral tissue from idiopathic Parkinson’s disease patients shows signs of oxidative damage. In this article we propose that dopamine-induced oxidative stress might be a common final pathway in the pathogenesis of the disease.},
  author       = {Smith, Ruben and Lotharius, Julie and Brundin, Patrik},
  issn         = {0023-7205},
  language     = {swe},
  number       = {15},
  pages        = {6--1329},
  publisher    = {Swedish Medical Association},
  series       = {Läkartidningen},
  title        = {Fria radikaler och sjuka proteiner - bovarna bakom Parkinsons sjukdom?[Free radicals and ailing proteins - the culprits behind Parkinson’s disease?]},
  volume       = {100},
  year         = {2003},
}