Consequences of Inadvertent Radioiodine Treatment of Graves' Disease and Thyroid Cancer in Undiagnosed Pregnancy. Can We Rely on Routine Pregnancy Testing?
(2008) In Acta Oncologica 47(1). p.145-149- Abstract
- Introduction. Radioiodine and most cytostatic treatments are contraindicated in pregnancy. Still, inadvertent therapy does occur. Radioiodine was given to two pregnant women with Graves' disease and thyroid cancer respectively, both in their 20th gestational week. Routine pregnancy tests based on urinary β-hCG had failed to indicate pregnancy in both cases. Methods. Estimation of doses to the foetuses and foetal thyroids. Scrutiny of pregnancy testing. Results and Conclusions. Doses to foetal thyroids were ablative (250-600 Gy). Total foetal dose in the Graves' patient was 100 mGy and compatible with survival, whereas a foetal dose of approximately 700 mGy together with induced hypothyroidism was fatal for the foetus of the cancer patient.... (More)
- Introduction. Radioiodine and most cytostatic treatments are contraindicated in pregnancy. Still, inadvertent therapy does occur. Radioiodine was given to two pregnant women with Graves' disease and thyroid cancer respectively, both in their 20th gestational week. Routine pregnancy tests based on urinary β-hCG had failed to indicate pregnancy in both cases. Methods. Estimation of doses to the foetuses and foetal thyroids. Scrutiny of pregnancy testing. Results and Conclusions. Doses to foetal thyroids were ablative (250-600 Gy). Total foetal dose in the Graves' patient was 100 mGy and compatible with survival, whereas a foetal dose of approximately 700 mGy together with induced hypothyroidism was fatal for the foetus of the cancer patient. Routine pregnancy tests may fail early and late in pregnancy. The possibility of pregnancy should be considered in all fertile women before therapy with radionuclides or cytostatic regimens, and a clinical investigation undertaken on wide indications with determination of serum β-hCG, preferably together with an ultrasound examination. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1141287
- author
- Berg, Gertrud E B ; Jacobsson, Lars ; Nyström, Ernst H ; Sjögreen Gleisner, Katarina LU and Tennvall, Jan LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Oncologica
- volume
- 47
- issue
- 1
- pages
- 145 - 149
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000252311700019
- scopus:37549005631
- pmid:17851865
- ISSN
- 1651-226X
- DOI
- 10.1080/02841860701558807
- language
- English
- LU publication?
- yes
- id
- 8135d559-462a-4efe-9265-da25cea575e3 (old id 1141287)
- date added to LUP
- 2016-04-01 14:54:37
- date last changed
- 2022-03-22 02:30:29
@article{8135d559-462a-4efe-9265-da25cea575e3,
abstract = {{Introduction. Radioiodine and most cytostatic treatments are contraindicated in pregnancy. Still, inadvertent therapy does occur. Radioiodine was given to two pregnant women with Graves' disease and thyroid cancer respectively, both in their 20th gestational week. Routine pregnancy tests based on urinary β-hCG had failed to indicate pregnancy in both cases. Methods. Estimation of doses to the foetuses and foetal thyroids. Scrutiny of pregnancy testing. Results and Conclusions. Doses to foetal thyroids were ablative (250-600 Gy). Total foetal dose in the Graves' patient was 100 mGy and compatible with survival, whereas a foetal dose of approximately 700 mGy together with induced hypothyroidism was fatal for the foetus of the cancer patient. Routine pregnancy tests may fail early and late in pregnancy. The possibility of pregnancy should be considered in all fertile women before therapy with radionuclides or cytostatic regimens, and a clinical investigation undertaken on wide indications with determination of serum β-hCG, preferably together with an ultrasound examination.}},
author = {{Berg, Gertrud E B and Jacobsson, Lars and Nyström, Ernst H and Sjögreen Gleisner, Katarina and Tennvall, Jan}},
issn = {{1651-226X}},
language = {{eng}},
number = {{1}},
pages = {{145--149}},
publisher = {{Taylor & Francis}},
series = {{Acta Oncologica}},
title = {{Consequences of Inadvertent Radioiodine Treatment of Graves' Disease and Thyroid Cancer in Undiagnosed Pregnancy. Can We Rely on Routine Pregnancy Testing?}},
url = {{http://dx.doi.org/10.1080/02841860701558807}},
doi = {{10.1080/02841860701558807}},
volume = {{47}},
year = {{2008}},
}