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In vivo gene delivery for development of mammalian models for Parkinson's disease

Ulusoy, Ayse LU ; Björklund, Tomas LU ; Hermening, Stephan LU and Kirik, Deniz LU (2008) In Experimental Neurology 209(1). p.89-100
Abstract
During the last decade, identification of the genes involved in familial forms of Parkinson's disease (PD) has advanced our understanding of the mechanisms underlying the development of different aspects of PD. However the available animal models still remain as the main limiting factor for the development of neuroprotective therapies that can halt the progression of the disease, through which we wish to provide a better quality of life for the PD patients. Here, we review the recently developed animal models based on overexpression of PD-associated genes using recombinant viral vectors. Recombinant adeno-associated viral vectors, in particular, have been very useful in targeting the nigral dopamine neurons both in the rodent and the... (More)
During the last decade, identification of the genes involved in familial forms of Parkinson's disease (PD) has advanced our understanding of the mechanisms underlying the development of different aspects of PD. However the available animal models still remain as the main limiting factor for the development of neuroprotective therapies that can halt the progression of the disease, through which we wish to provide a better quality of life for the PD patients. Here, we review the recently developed animal models based on overexpression of PD-associated genes using recombinant viral vectors. Recombinant adeno-associated viral vectors, in particular, have been very useful in targeting the nigral dopamine neurons both in the rodent and the primate brain. In order to provide insights into the establishment of these models in the laboratory, we will not only give an overview of the results from these studies but also cover practical issues related to the production and handling of the viral vectors, which are critical for the successful application of this approach. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Neurology
volume
209
issue
1
pages
89 - 100
publisher
Academic Press
external identifiers
  • pmid:18028909
  • wos:000252500900015
  • scopus:37549032800
ISSN
0014-4886
DOI
10.1016/j.expneurol.2007.09.011
language
English
LU publication?
yes
id
1dd61e5c-4110-4c4d-97fc-4ee3a193c79e (old id 1141533)
date added to LUP
2008-08-05 13:20:45
date last changed
2017-09-10 03:33:42
@article{1dd61e5c-4110-4c4d-97fc-4ee3a193c79e,
  abstract     = {During the last decade, identification of the genes involved in familial forms of Parkinson's disease (PD) has advanced our understanding of the mechanisms underlying the development of different aspects of PD. However the available animal models still remain as the main limiting factor for the development of neuroprotective therapies that can halt the progression of the disease, through which we wish to provide a better quality of life for the PD patients. Here, we review the recently developed animal models based on overexpression of PD-associated genes using recombinant viral vectors. Recombinant adeno-associated viral vectors, in particular, have been very useful in targeting the nigral dopamine neurons both in the rodent and the primate brain. In order to provide insights into the establishment of these models in the laboratory, we will not only give an overview of the results from these studies but also cover practical issues related to the production and handling of the viral vectors, which are critical for the successful application of this approach.},
  author       = {Ulusoy, Ayse and Björklund, Tomas and Hermening, Stephan and Kirik, Deniz},
  issn         = {0014-4886},
  language     = {eng},
  number       = {1},
  pages        = {89--100},
  publisher    = {Academic Press},
  series       = {Experimental Neurology},
  title        = {In vivo gene delivery for development of mammalian models for Parkinson's disease},
  url          = {http://dx.doi.org/10.1016/j.expneurol.2007.09.011},
  volume       = {209},
  year         = {2008},
}