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Superantigen-Induced Regulatory T Cells Display Different Suppressive Functions in the Presence or Absence of Natural CD4(+)CD25(+) Regulatory T Cells In Vivo.

Grundström, Susanna; Cederbom, Lukas LU ; Sundstedt, Anette; Scheipers, Peter and Ivars, Fredrik LU (2003) In Journal of Immunology 170(10). p.5008-5017
Abstract
Repeated exposures to both microbial and innocuous Ags in vivo have been reported to both eliminate and tolerize T cells after their initial activation and expansion. The remaining tolerant T cells have been shown to suppress the response of naive T cells in vitro. This feature is reminiscent of natural CD4+CD25+ regulatory T cells. However, it is not known whether the regulatory function of in vivo-tolerized T cells is similar to the function of natural CD4+CD25+ regulatory T cells. In this study, we demonstrate that CD4+CD25+ as well as CD4+CD25- T cells isolated from mice treated with superantigen three consecutive times to induce tolerance were functionally comparable to natural CD4+CD25+ regulatory T cells, albeit more potent. The... (More)
Repeated exposures to both microbial and innocuous Ags in vivo have been reported to both eliminate and tolerize T cells after their initial activation and expansion. The remaining tolerant T cells have been shown to suppress the response of naive T cells in vitro. This feature is reminiscent of natural CD4+CD25+ regulatory T cells. However, it is not known whether the regulatory function of in vivo-tolerized T cells is similar to the function of natural CD4+CD25+ regulatory T cells. In this study, we demonstrate that CD4+CD25+ as well as CD4+CD25- T cells isolated from mice treated with superantigen three consecutive times to induce tolerance were functionally comparable to natural CD4+CD25+ regulatory T cells, albeit more potent. The different subpopulations of in vivo-tolerized CD4+ T cells efficiently down-modulated costimulatory molecules on dendritic cells, and their suppressive functions were strictly cell contact dependent. Importantly, we demonstrate that conventional CD4+CD25- T cells could also be induced to acquire regulatory functions by the same regimen in the absence of natural regulatory T cells in vivo, but that such regulatory cells were functionally different. (Less)
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Contribution to journal
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published
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in
Journal of Immunology
volume
170
issue
10
pages
5008 - 5017
publisher
American Association of Immunologists
external identifiers
  • wos:000182758200017
  • pmid:12734345
  • scopus:0038326625
ISSN
1550-6606
language
English
LU publication?
yes
id
7991720a-5fc4-41de-94ba-91194ac843b5 (old id 114167)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12734345&dopt=Abstract
date added to LUP
2007-07-12 14:40:19
date last changed
2018-05-29 11:40:03
@article{7991720a-5fc4-41de-94ba-91194ac843b5,
  abstract     = {Repeated exposures to both microbial and innocuous Ags in vivo have been reported to both eliminate and tolerize T cells after their initial activation and expansion. The remaining tolerant T cells have been shown to suppress the response of naive T cells in vitro. This feature is reminiscent of natural CD4+CD25+ regulatory T cells. However, it is not known whether the regulatory function of in vivo-tolerized T cells is similar to the function of natural CD4+CD25+ regulatory T cells. In this study, we demonstrate that CD4+CD25+ as well as CD4+CD25- T cells isolated from mice treated with superantigen three consecutive times to induce tolerance were functionally comparable to natural CD4+CD25+ regulatory T cells, albeit more potent. The different subpopulations of in vivo-tolerized CD4+ T cells efficiently down-modulated costimulatory molecules on dendritic cells, and their suppressive functions were strictly cell contact dependent. Importantly, we demonstrate that conventional CD4+CD25- T cells could also be induced to acquire regulatory functions by the same regimen in the absence of natural regulatory T cells in vivo, but that such regulatory cells were functionally different.},
  author       = {Grundström, Susanna and Cederbom, Lukas and Sundstedt, Anette and Scheipers, Peter and Ivars, Fredrik},
  issn         = {1550-6606},
  language     = {eng},
  number       = {10},
  pages        = {5008--5017},
  publisher    = {American Association of Immunologists},
  series       = {Journal of Immunology},
  title        = {Superantigen-Induced Regulatory T Cells Display Different Suppressive Functions in the Presence or Absence of Natural CD4(+)CD25(+) Regulatory T Cells In Vivo.},
  volume       = {170},
  year         = {2003},
}