Superantigen-Induced Regulatory T Cells Display Different Suppressive Functions in the Presence or Absence of Natural CD4(+)CD25(+) Regulatory T Cells In Vivo.
(2003) In Journal of Immunology 170(10). p.5008-5017- Abstract
- Repeated exposures to both microbial and innocuous Ags in vivo have been reported to both eliminate and tolerize T cells after their initial activation and expansion. The remaining tolerant T cells have been shown to suppress the response of naive T cells in vitro. This feature is reminiscent of natural CD4+CD25+ regulatory T cells. However, it is not known whether the regulatory function of in vivo-tolerized T cells is similar to the function of natural CD4+CD25+ regulatory T cells. In this study, we demonstrate that CD4+CD25+ as well as CD4+CD25- T cells isolated from mice treated with superantigen three consecutive times to induce tolerance were functionally comparable to natural CD4+CD25+ regulatory T cells, albeit more potent. The... (More)
- Repeated exposures to both microbial and innocuous Ags in vivo have been reported to both eliminate and tolerize T cells after their initial activation and expansion. The remaining tolerant T cells have been shown to suppress the response of naive T cells in vitro. This feature is reminiscent of natural CD4+CD25+ regulatory T cells. However, it is not known whether the regulatory function of in vivo-tolerized T cells is similar to the function of natural CD4+CD25+ regulatory T cells. In this study, we demonstrate that CD4+CD25+ as well as CD4+CD25- T cells isolated from mice treated with superantigen three consecutive times to induce tolerance were functionally comparable to natural CD4+CD25+ regulatory T cells, albeit more potent. The different subpopulations of in vivo-tolerized CD4+ T cells efficiently down-modulated costimulatory molecules on dendritic cells, and their suppressive functions were strictly cell contact dependent. Importantly, we demonstrate that conventional CD4+CD25- T cells could also be induced to acquire regulatory functions by the same regimen in the absence of natural regulatory T cells in vivo, but that such regulatory cells were functionally different. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/114167
- author
- Grundström, Susanna ; Cederbom, Lukas LU ; Sundstedt, Anette ; Scheipers, Peter and Ivars, Fredrik LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Immunology
- volume
- 170
- issue
- 10
- pages
- 5008 - 5017
- publisher
- American Association of Immunologists
- external identifiers
-
- wos:000182758200017
- pmid:12734345
- scopus:0038326625
- ISSN
- 1550-6606
- language
- English
- LU publication?
- yes
- id
- 7991720a-5fc4-41de-94ba-91194ac843b5 (old id 114167)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12734345&dopt=Abstract
- date added to LUP
- 2016-04-01 16:44:41
- date last changed
- 2022-01-28 21:50:27
@article{7991720a-5fc4-41de-94ba-91194ac843b5,
abstract = {{Repeated exposures to both microbial and innocuous Ags in vivo have been reported to both eliminate and tolerize T cells after their initial activation and expansion. The remaining tolerant T cells have been shown to suppress the response of naive T cells in vitro. This feature is reminiscent of natural CD4+CD25+ regulatory T cells. However, it is not known whether the regulatory function of in vivo-tolerized T cells is similar to the function of natural CD4+CD25+ regulatory T cells. In this study, we demonstrate that CD4+CD25+ as well as CD4+CD25- T cells isolated from mice treated with superantigen three consecutive times to induce tolerance were functionally comparable to natural CD4+CD25+ regulatory T cells, albeit more potent. The different subpopulations of in vivo-tolerized CD4+ T cells efficiently down-modulated costimulatory molecules on dendritic cells, and their suppressive functions were strictly cell contact dependent. Importantly, we demonstrate that conventional CD4+CD25- T cells could also be induced to acquire regulatory functions by the same regimen in the absence of natural regulatory T cells in vivo, but that such regulatory cells were functionally different.}},
author = {{Grundström, Susanna and Cederbom, Lukas and Sundstedt, Anette and Scheipers, Peter and Ivars, Fredrik}},
issn = {{1550-6606}},
language = {{eng}},
number = {{10}},
pages = {{5008--5017}},
publisher = {{American Association of Immunologists}},
series = {{Journal of Immunology}},
title = {{Superantigen-Induced Regulatory T Cells Display Different Suppressive Functions in the Presence or Absence of Natural CD4(+)CD25(+) Regulatory T Cells In Vivo.}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12734345&dopt=Abstract}},
volume = {{170}},
year = {{2003}},
}