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Association between Gm allotypes and asthma severity from childhood to young middle age

Gustafsson, P; Oxelius, Vivi-Anne LU ; Nilsson, S and Kjellman, B (2008) In Respiratory Medicine 102(2). p.266-272
Abstract
Immunoglobulin constant heavy G chain (IGHG) gene polymorphisms are associated with atopy and can be determined by the serum Gm allotypes. We studied whether certain polymorphisms are related to asthma severity and to the extent or intensity of allergic sensitization in asthmatic subjects followed from childhood to young middle age.



Fifty-five subjects (28 males) with childhood asthma were all followed-up prospectively on six occasions from a mean age of 9 to 35 years in a study including asthma severity scoring, spirometry, skin prick, and specific serum IgE antibody testing. At the last visit, extended lung function tests and a cold air challenge were performed, and IGHG gene polymorphisms were identified by the... (More)
Immunoglobulin constant heavy G chain (IGHG) gene polymorphisms are associated with atopy and can be determined by the serum Gm allotypes. We studied whether certain polymorphisms are related to asthma severity and to the extent or intensity of allergic sensitization in asthmatic subjects followed from childhood to young middle age.



Fifty-five subjects (28 males) with childhood asthma were all followed-up prospectively on six occasions from a mean age of 9 to 35 years in a study including asthma severity scoring, spirometry, skin prick, and specific serum IgE antibody testing. At the last visit, extended lung function tests and a cold air challenge were performed, and IGHG gene polymorphisms were identified by the alternative serum IgG subclass allotypes, employing ELISA and double immunodiffusion.



The 19 subjects with the homozygous IGHG*bf/*bf genotype (originating from the IGHG3*b and the IGHG1*f alleles, which are in strong linkage disequilibrium), showed significantly higher asthma scores, lower airway function, and greater bronchodilator responses from childhood to adulthood, and in middle age greater airway hyperresponsiveness, compared to the subjects with the IGHG*bf/*ga or IGHG*ga/*ga genotypes. Among the subjects sensitized to animal danders, those with the IGHG*bf/*bf genotype showed the highest specific IgE levels.



In conclusion, IGHG gene polymorphisms were associated with the severity and outcome of childhood asthma, and with the intensity of allergic sensitization. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Medicine
volume
102
issue
2
pages
266 - 272
publisher
Elsevier
external identifiers
  • wos:000252809500011
  • scopus:37349089045
ISSN
1532-3064
DOI
10.1016/j.rmed.2007.09.003
language
English
LU publication?
yes
id
cf2f3517-3e97-4e7d-b6ae-a8ab1605e798 (old id 1142438)
date added to LUP
2008-08-05 14:14:01
date last changed
2017-01-01 06:34:26
@article{cf2f3517-3e97-4e7d-b6ae-a8ab1605e798,
  abstract     = {Immunoglobulin constant heavy G chain (IGHG) gene polymorphisms are associated with atopy and can be determined by the serum Gm allotypes. We studied whether certain polymorphisms are related to asthma severity and to the extent or intensity of allergic sensitization in asthmatic subjects followed from childhood to young middle age.<br/><br>
<br/><br>
Fifty-five subjects (28 males) with childhood asthma were all followed-up prospectively on six occasions from a mean age of 9 to 35 years in a study including asthma severity scoring, spirometry, skin prick, and specific serum IgE antibody testing. At the last visit, extended lung function tests and a cold air challenge were performed, and IGHG gene polymorphisms were identified by the alternative serum IgG subclass allotypes, employing ELISA and double immunodiffusion.<br/><br>
<br/><br>
The 19 subjects with the homozygous IGHG*bf/*bf genotype (originating from the IGHG3*b and the IGHG1*f alleles, which are in strong linkage disequilibrium), showed significantly higher asthma scores, lower airway function, and greater bronchodilator responses from childhood to adulthood, and in middle age greater airway hyperresponsiveness, compared to the subjects with the IGHG*bf/*ga or IGHG*ga/*ga genotypes. Among the subjects sensitized to animal danders, those with the IGHG*bf/*bf genotype showed the highest specific IgE levels.<br/><br>
<br/><br>
In conclusion, IGHG gene polymorphisms were associated with the severity and outcome of childhood asthma, and with the intensity of allergic sensitization.},
  author       = {Gustafsson, P and Oxelius, Vivi-Anne and Nilsson, S and Kjellman, B},
  issn         = {1532-3064},
  language     = {eng},
  number       = {2},
  pages        = {266--272},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Association between Gm allotypes and asthma severity from childhood to young middle age},
  url          = {http://dx.doi.org/10.1016/j.rmed.2007.09.003},
  volume       = {102},
  year         = {2008},
}