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Allergic rhinitis with hyper-responsiveness differ from asthma in degree of peripheral obstruction during metacholine challenge test.

Aronsson, David LU ; Tufvesson, Ellen LU ; Ankerst, Jaro LU and Bjermer, Leif LU (2008) In Clinical Physiology and Functional Imaging 28(2). p.81-85
Abstract
Allergic rhinitis (AR) is a risk factor for developing clinical asthma. Moreover, AR is often associated with bronchial hyper-responsiveness (BHR). The aim of this study was to compare the degree of involvement of the peripheral airways during metacholine (MCh) challenge test in asthmatics and patients with AR with or without BHR by using the impulse oscillometry (IOS) technique. Fifty-three patients with seasonal AR were investigated with MCh challenge test and IOS. Thirteen healthy non-reactive subjects served as controls. MCh challenge test was performed, cut-off value FEV1PD20 2000 μg. Linear regression analysis was used to calculate a MCh/FEV1 slope (Slope-FEV1MCh), which was used as an index of BHR. IOS was performed, measuring... (More)
Allergic rhinitis (AR) is a risk factor for developing clinical asthma. Moreover, AR is often associated with bronchial hyper-responsiveness (BHR). The aim of this study was to compare the degree of involvement of the peripheral airways during metacholine (MCh) challenge test in asthmatics and patients with AR with or without BHR by using the impulse oscillometry (IOS) technique. Fifty-three patients with seasonal AR were investigated with MCh challenge test and IOS. Thirteen healthy non-reactive subjects served as controls. MCh challenge test was performed, cut-off value FEV1PD20 2000 μg. Linear regression analysis was used to calculate a MCh/FEV1 slope (Slope-FEV1MCh), which was used as an index of BHR. IOS was performed, measuring respiratory resistance and reactance during the MCh challenge test. Twenty-six subjects had both AR and asthma symptoms, 27 patients reported AR only, without asthma symptoms, 17 (63%) manifested BHR by spirometric criteria. Patients with AR and symptoms of asthma manifested greater peripheral airway obstruction compared to those with AR only with BHR. Increased peripheral obstruction in the asthmatic group compared to patients with AR and BHR may explain previous findings that asthmatics perceive greater airway obstruction during MCh challenge tests. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging
volume
28
issue
2
pages
81 - 85
publisher
Wiley Online Library
external identifiers
  • wos:000252897100003
  • scopus:39049122056
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2007.00772.x
language
English
LU publication?
yes
id
a0d65a89-6459-417b-8c1f-7a8e01e3d12d (old id 1142805)
date added to LUP
2008-08-01 11:12:45
date last changed
2017-04-30 07:42:33
@article{a0d65a89-6459-417b-8c1f-7a8e01e3d12d,
  abstract     = {Allergic rhinitis (AR) is a risk factor for developing clinical asthma. Moreover, AR is often associated with bronchial hyper-responsiveness (BHR). The aim of this study was to compare the degree of involvement of the peripheral airways during metacholine (MCh) challenge test in asthmatics and patients with AR with or without BHR by using the impulse oscillometry (IOS) technique. Fifty-three patients with seasonal AR were investigated with MCh challenge test and IOS. Thirteen healthy non-reactive subjects served as controls. MCh challenge test was performed, cut-off value FEV1PD20 2000 μg. Linear regression analysis was used to calculate a MCh/FEV1 slope (Slope-FEV1MCh), which was used as an index of BHR. IOS was performed, measuring respiratory resistance and reactance during the MCh challenge test. Twenty-six subjects had both AR and asthma symptoms, 27 patients reported AR only, without asthma symptoms, 17 (63%) manifested BHR by spirometric criteria. Patients with AR and symptoms of asthma manifested greater peripheral airway obstruction compared to those with AR only with BHR. Increased peripheral obstruction in the asthmatic group compared to patients with AR and BHR may explain previous findings that asthmatics perceive greater airway obstruction during MCh challenge tests.},
  author       = {Aronsson, David and Tufvesson, Ellen and Ankerst, Jaro and Bjermer, Leif},
  issn         = {1475-0961},
  language     = {eng},
  number       = {2},
  pages        = {81--85},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Allergic rhinitis with hyper-responsiveness differ from asthma in degree of peripheral obstruction during metacholine challenge test.},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.2007.00772.x},
  volume       = {28},
  year         = {2008},
}