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Pericytes: gatekeepers in tumour cell metastasis?

Gerhardt, H and Semb, Henrik LU (2008) In Journal of Molecular Medicine 86(2). p.135-144
Abstract
Tumour cells use two major routes to spread during metastasis, e.g. lymph vessels and blood vessels within or surrounding the primary tumour. The growth rate of the primary tumour often correlates with the quantity of new blood vessels that form within the tumour. However, qualitative abnormalities of the tumour vasculature profoundly affect the perfusion of the primary tumour and the escape of tumour cells into the circulation. In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Molecular Medicine
volume
86
issue
2
pages
135 - 144
publisher
Springer
external identifiers
  • pmid:17891366
  • wos:000252799300002
  • scopus:38649107709
ISSN
1432-1440
DOI
10.1007/s00109-007-0258-2
language
English
LU publication?
yes
id
59ee0243-3763-4296-ad83-574fa629a2fa (old id 1143587)
date added to LUP
2008-07-29 15:57:30
date last changed
2017-11-19 03:30:06
@article{59ee0243-3763-4296-ad83-574fa629a2fa,
  abstract     = {Tumour cells use two major routes to spread during metastasis, e.g. lymph vessels and blood vessels within or surrounding the primary tumour. The growth rate of the primary tumour often correlates with the quantity of new blood vessels that form within the tumour. However, qualitative abnormalities of the tumour vasculature profoundly affect the perfusion of the primary tumour and the escape of tumour cells into the circulation. In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis.},
  author       = {Gerhardt, H and Semb, Henrik},
  issn         = {1432-1440},
  language     = {eng},
  number       = {2},
  pages        = {135--144},
  publisher    = {Springer},
  series       = {Journal of Molecular Medicine},
  title        = {Pericytes: gatekeepers in tumour cell metastasis?},
  url          = {http://dx.doi.org/10.1007/s00109-007-0258-2},
  volume       = {86},
  year         = {2008},
}