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An improved method for detecting and delineating genomic regions with altered gene expression in cancer

Nilsson, Björn LU ; Johansson, Mikael; Heyden, Anders LU ; Nelander, Sven and Fioretos, Thoas LU (2008) In Genome Biology 9(1).
Abstract
ABSTRACT: Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation (TV) minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genome Biology
volume
9
issue
1
publisher
BioMed Central
external identifiers
  • pmid:18208590
  • wos:000253779800021
  • scopus:46249086537
ISSN
1474-7596
DOI
10.1186/gb-2008-9-1-r13
language
English
LU publication?
yes
id
76b0d4ba-4057-424d-bcfb-8dae11c50cc0 (old id 1143863)
date added to LUP
2008-08-15 08:37:48
date last changed
2017-07-23 04:03:00
@article{76b0d4ba-4057-424d-bcfb-8dae11c50cc0,
  abstract     = {ABSTRACT: Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation (TV) minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.},
  articleno    = {R13},
  author       = {Nilsson, Björn and Johansson, Mikael and Heyden, Anders and Nelander, Sven and Fioretos, Thoas},
  issn         = {1474-7596},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Genome Biology},
  title        = {An improved method for detecting and delineating genomic regions with altered gene expression in cancer},
  url          = {http://dx.doi.org/10.1186/gb-2008-9-1-r13},
  volume       = {9},
  year         = {2008},
}