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Association between C-reactive protein and personality traits in women

Henningsson, Susanne; Baghaei, Fariba; Rosmond, Roland; Holm, Göran; Landen, Mikael; Anckarsäter, Henrik LU and Ekman, Agneta (2008) In Behavioral and Brain Functions 4(16).
Abstract
Background



While low-grade inflammation has consistently been observed in subjects with depression, studies on the possible relationship between inflammation and other aspects of brain function are as yet sparse. In this study, we aimed to investigate the possible association between serum levels of the inflammation marker C-reactive protein (CRP) and personality traits.

Methods



In this study, serum levels of high-sensitivity CRP were determined by ELISA in a population of 270 42-year-old women recruited from the population registry who had been assessed using the Temperament and Character Inventory. Self-reported previous or ongoing depression was also recorded. Unpaired two-tailed t-tests... (More)
Background



While low-grade inflammation has consistently been observed in subjects with depression, studies on the possible relationship between inflammation and other aspects of brain function are as yet sparse. In this study, we aimed to investigate the possible association between serum levels of the inflammation marker C-reactive protein (CRP) and personality traits.

Methods



In this study, serum levels of high-sensitivity CRP were determined by ELISA in a population of 270 42-year-old women recruited from the population registry who had been assessed using the Temperament and Character Inventory. Self-reported previous or ongoing depression was also recorded. Unpaired two-tailed t-tests were used for comparison between two groups and correlations were evaluated by the calculation of Pearson's r-coefficient.

Results



The temperament trait harm avoidance was positively (r = 0.227, p < 0.05) and the character trait self-directedness was negatively (r = -0.261, p < 0.01) associated with serum levels of CRP (p-values corrected for multiple comparisons). The correlations between the personality traits and CRP were observed also after exclusion of subjects reporting ongoing depression (n = 26). Whereas women reporting ongoing depression showed significantly increased levels of CRP as compared to non-depressed women (n = 155), women reporting a history of depression displayed no significant difference in CRP levels as compared to women that reported that they had never been depressed.

Conclusion



Serum levels of CRP in women was found to be associated with the personality traits harm avoidance and self-directedness. In addition, moderately elevated levels may be a state dependent marker of depression. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Behavioral and Brain Functions
volume
4
issue
16
publisher
BioMed Central
external identifiers
  • scopus:43249105978
ISSN
1744-9081
DOI
10.1186/1744-9081-4-16
language
English
LU publication?
no
id
bec718a7-e531-44da-afca-109339989208 (old id 1144139)
date added to LUP
2008-08-12 13:19:19
date last changed
2017-01-01 06:09:48
@article{bec718a7-e531-44da-afca-109339989208,
  abstract     = {Background<br/><br>
<br/><br>
While low-grade inflammation has consistently been observed in subjects with depression, studies on the possible relationship between inflammation and other aspects of brain function are as yet sparse. In this study, we aimed to investigate the possible association between serum levels of the inflammation marker C-reactive protein (CRP) and personality traits.<br/><br>
Methods<br/><br>
<br/><br>
In this study, serum levels of high-sensitivity CRP were determined by ELISA in a population of 270 42-year-old women recruited from the population registry who had been assessed using the Temperament and Character Inventory. Self-reported previous or ongoing depression was also recorded. Unpaired two-tailed t-tests were used for comparison between two groups and correlations were evaluated by the calculation of Pearson's r-coefficient.<br/><br>
Results<br/><br>
<br/><br>
The temperament trait harm avoidance was positively (r = 0.227, p &lt; 0.05) and the character trait self-directedness was negatively (r = -0.261, p &lt; 0.01) associated with serum levels of CRP (p-values corrected for multiple comparisons). The correlations between the personality traits and CRP were observed also after exclusion of subjects reporting ongoing depression (n = 26). Whereas women reporting ongoing depression showed significantly increased levels of CRP as compared to non-depressed women (n = 155), women reporting a history of depression displayed no significant difference in CRP levels as compared to women that reported that they had never been depressed.<br/><br>
Conclusion<br/><br>
<br/><br>
Serum levels of CRP in women was found to be associated with the personality traits harm avoidance and self-directedness. In addition, moderately elevated levels may be a state dependent marker of depression.},
  author       = {Henningsson, Susanne and Baghaei, Fariba and Rosmond, Roland and Holm, Göran and Landen, Mikael and Anckarsäter, Henrik and Ekman, Agneta},
  issn         = {1744-9081},
  language     = {eng},
  number       = {16},
  publisher    = {BioMed Central},
  series       = {Behavioral and Brain Functions},
  title        = {Association between C-reactive protein and personality traits in women},
  url          = {http://dx.doi.org/10.1186/1744-9081-4-16},
  volume       = {4},
  year         = {2008},
}