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Activated Protein C Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?

Kölbel, Tilo LU ; Strandberg, Karin LU ; Donath, Tobias; Mattiasson, Ingrid LU ; Stenflo, Johan LU and Lindblad, Bengt LU (2008) In Vascular and Endovascular Surgery 42(2). p.135-140
Abstract
Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = <0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P =... (More)
Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = <0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P = 0.004) and with age (r = 0.19, P = 0.004). APC-PCI did not correlate with the AAA-growth rate (r = 0.11, P = 0.14). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
thrombus, coagulation, aneurysm, aorta
in
Vascular and Endovascular Surgery
volume
42
issue
2
pages
135 - 140
publisher
SAGE Publications Inc.
external identifiers
  • pmid:18184931
  • wos:000260963100006
  • scopus:42249113474
ISSN
1938-9116
DOI
10.1177/1538574407311108
language
English
LU publication?
yes
id
3c6dd71a-cab0-460d-95c7-5e88f47a73de (old id 1144540)
date added to LUP
2008-08-14 16:04:13
date last changed
2017-08-27 04:05:33
@article{3c6dd71a-cab0-460d-95c7-5e88f47a73de,
  abstract     = {Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = &lt;0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P = 0.004) and with age (r = 0.19, P = 0.004). APC-PCI did not correlate with the AAA-growth rate (r = 0.11, P = 0.14).},
  author       = {Kölbel, Tilo and Strandberg, Karin and Donath, Tobias and Mattiasson, Ingrid and Stenflo, Johan and Lindblad, Bengt},
  issn         = {1938-9116},
  keyword      = {thrombus,coagulation,aneurysm,aorta},
  language     = {eng},
  number       = {2},
  pages        = {135--140},
  publisher    = {SAGE Publications Inc.},
  series       = {Vascular and Endovascular Surgery},
  title        = {Activated Protein C Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?},
  url          = {http://dx.doi.org/10.1177/1538574407311108},
  volume       = {42},
  year         = {2008},
}