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Activated Protein C Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?

Kölbel, Tilo LU ; Strandberg, Karin LU ; Donath, Tobias ; Mattiasson, Ingrid LU ; Stenflo, Johan LU and Lindblad, Bengt LU (2008) In Vascular and Endovascular Surgery 42(2). p.135-140
Abstract
Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = <0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P =... (More)
Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = <0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P = 0.004) and with age (r = 0.19, P = 0.004). APC-PCI did not correlate with the AAA-growth rate (r = 0.11, P = 0.14). (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
thrombus, coagulation, aneurysm, aorta
in
Vascular and Endovascular Surgery
volume
42
issue
2
pages
135 - 140
publisher
SAGE Publications
external identifiers
  • pmid:18184931
  • wos:000260963100006
  • scopus:42249113474
ISSN
1938-9116
DOI
10.1177/1538574407311108
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit for Clinical Vascular Disease Research (013242410), Emergency medicine/Medicine/Surgery (013240200), Clinical Chemistry, Malmö (013016000)
id
3c6dd71a-cab0-460d-95c7-5e88f47a73de (old id 1144540)
date added to LUP
2016-04-01 12:07:50
date last changed
2022-01-26 23:14:05
@article{3c6dd71a-cab0-460d-95c7-5e88f47a73de,
  abstract     = {{Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = &lt;0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P = 0.004) and with age (r = 0.19, P = 0.004). APC-PCI did not correlate with the AAA-growth rate (r = 0.11, P = 0.14).}},
  author       = {{Kölbel, Tilo and Strandberg, Karin and Donath, Tobias and Mattiasson, Ingrid and Stenflo, Johan and Lindblad, Bengt}},
  issn         = {{1938-9116}},
  keywords     = {{thrombus; coagulation; aneurysm; aorta}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{135--140}},
  publisher    = {{SAGE Publications}},
  series       = {{Vascular and Endovascular Surgery}},
  title        = {{Activated Protein C Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?}},
  url          = {{http://dx.doi.org/10.1177/1538574407311108}},
  doi          = {{10.1177/1538574407311108}},
  volume       = {{42}},
  year         = {{2008}},
}