Activated Protein C Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?
(2008) In Vascular and Endovascular Surgery 42(2). p.135-140- Abstract
- Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = <0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P =... (More)
- Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = <0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P = 0.004) and with age (r = 0.19, P = 0.004). APC-PCI did not correlate with the AAA-growth rate (r = 0.11, P = 0.14). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1144540
- author
- Kölbel, Tilo LU ; Strandberg, Karin LU ; Donath, Tobias ; Mattiasson, Ingrid LU ; Stenflo, Johan LU and Lindblad, Bengt LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- thrombus, coagulation, aneurysm, aorta
- in
- Vascular and Endovascular Surgery
- volume
- 42
- issue
- 2
- pages
- 135 - 140
- publisher
- SAGE Publications
- external identifiers
-
- pmid:18184931
- wos:000260963100006
- scopus:42249113474
- ISSN
- 1938-9116
- DOI
- 10.1177/1538574407311108
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit for Clinical Vascular Disease Research (013242410), Emergency medicine/Medicine/Surgery (013240200), Clinical Chemistry, Malmö (013016000)
- id
- 3c6dd71a-cab0-460d-95c7-5e88f47a73de (old id 1144540)
- date added to LUP
- 2016-04-01 12:07:50
- date last changed
- 2022-01-26 23:14:05
@article{3c6dd71a-cab0-460d-95c7-5e88f47a73de, abstract = {{Increased thrombin activation has been documented in patients with abdominal aortic aneurysm (AAA). APC-PCI complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA relative and a control group and the association between aneurysm size, growth rate and APC-PCI was studied. The patients were divided into cohorts according to the AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA-cohorts (n = 232; median: 0.36 mg/L; 10th - 90th percentile: 0.18-1.01) compared to the control group (n = 41; median: 0.19 mg/L; 10th - 90th percentile: 0.11-0.31; P = <0.001). APC-PCI correlated with the AAA diameter (r = 0.22, P = 0.001), with the BMI (r = -0.19, P = 0.004) and with age (r = 0.19, P = 0.004). APC-PCI did not correlate with the AAA-growth rate (r = 0.11, P = 0.14).}}, author = {{Kölbel, Tilo and Strandberg, Karin and Donath, Tobias and Mattiasson, Ingrid and Stenflo, Johan and Lindblad, Bengt}}, issn = {{1938-9116}}, keywords = {{thrombus; coagulation; aneurysm; aorta}}, language = {{eng}}, number = {{2}}, pages = {{135--140}}, publisher = {{SAGE Publications}}, series = {{Vascular and Endovascular Surgery}}, title = {{Activated Protein C Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?}}, url = {{http://dx.doi.org/10.1177/1538574407311108}}, doi = {{10.1177/1538574407311108}}, volume = {{42}}, year = {{2008}}, }