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Multifocal electroretinogram (mfERG) in patients with diabetes mellitus and an enlarged foveal avascular zone (FAZ)

Tyrberg, Maria LU ; Ponjavic, Vesna LU and Lövestam Adrian, Monica LU (2008) In Documenta Ophthalmologica 117. p.185-189
Abstract
Purpose To assess the relationship between foveal microcirculation and central retinal function in diabetic patients having both an enlarged foveal avascular zone (FAZ) and a preserved visual acuity (0.6 or better). Methods Twenty-five patients with diabetes type 1 or 2 with an enlarged FAZ (largest diameter > 650 mum) measured in fluorescein angiograms were examined with multifocal ERG (mfERG). The largest FAZ diameter, the FAZ area as well as the adjacent perifoveal intercapillary area (PIA), was calculated from the fluorescein angiogram. The retinopathy level was mild to preproliferative. There was no macular edema and no eye had previously been treated with photocoagulation. Results The mean FAZ diameter was 0.92 +/- 0.17 mm and the... (More)
Purpose To assess the relationship between foveal microcirculation and central retinal function in diabetic patients having both an enlarged foveal avascular zone (FAZ) and a preserved visual acuity (0.6 or better). Methods Twenty-five patients with diabetes type 1 or 2 with an enlarged FAZ (largest diameter > 650 mum) measured in fluorescein angiograms were examined with multifocal ERG (mfERG). The largest FAZ diameter, the FAZ area as well as the adjacent perifoveal intercapillary area (PIA), was calculated from the fluorescein angiogram. The retinopathy level was mild to preproliferative. There was no macular edema and no eye had previously been treated with photocoagulation. Results The mean FAZ diameter was 0.92 +/- 0.17 mm and the mean summed area (FAZ and PIA) was 0.74 +/- 0.24 mm(2). There was a significant correlation between increasing FAZ diameter and increasing implicit time of the innermost concentric rings and of the third concentric ring in the first order kernel of the mfERG (P = 0.03 and P = 0.008, respectively). An increasing summed area (FAZ and PIA) was correlated to increasing implicit time in the same areas of the mfERG (P = 0.005 and P = 0.026, respectively). No correlation was seen between the ischemic areas and the mfERG amplitudes. Conclusion A correlation between the ischemic areas and prolonged implicit time in the mfERG indicates that alterations in neuronal macular function due to ischemia might precede the deterioration of visual acuity. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Multifocal electroretinogram (mfERG), Diabetic retinopathy, Fluorescein angiogram (FA), Foveal avascular zone (FAZ)
in
Documenta Ophthalmologica
volume
117
pages
185 - 189
publisher
Springer
external identifiers
  • pmid:18324430
  • wos:000260262200002
  • scopus:55649106546
ISSN
1573-2622
DOI
10.1007/s10633-008-9120-2
language
English
LU publication?
yes
id
5417a3fd-ed3b-4656-a07a-e1b9946ae488 (old id 1144652)
date added to LUP
2008-08-14 16:21:57
date last changed
2017-09-17 04:55:12
@article{5417a3fd-ed3b-4656-a07a-e1b9946ae488,
  abstract     = {Purpose To assess the relationship between foveal microcirculation and central retinal function in diabetic patients having both an enlarged foveal avascular zone (FAZ) and a preserved visual acuity (0.6 or better). Methods Twenty-five patients with diabetes type 1 or 2 with an enlarged FAZ (largest diameter > 650 mum) measured in fluorescein angiograms were examined with multifocal ERG (mfERG). The largest FAZ diameter, the FAZ area as well as the adjacent perifoveal intercapillary area (PIA), was calculated from the fluorescein angiogram. The retinopathy level was mild to preproliferative. There was no macular edema and no eye had previously been treated with photocoagulation. Results The mean FAZ diameter was 0.92 +/- 0.17 mm and the mean summed area (FAZ and PIA) was 0.74 +/- 0.24 mm(2). There was a significant correlation between increasing FAZ diameter and increasing implicit time of the innermost concentric rings and of the third concentric ring in the first order kernel of the mfERG (P = 0.03 and P = 0.008, respectively). An increasing summed area (FAZ and PIA) was correlated to increasing implicit time in the same areas of the mfERG (P = 0.005 and P = 0.026, respectively). No correlation was seen between the ischemic areas and the mfERG amplitudes. Conclusion A correlation between the ischemic areas and prolonged implicit time in the mfERG indicates that alterations in neuronal macular function due to ischemia might precede the deterioration of visual acuity.},
  author       = {Tyrberg, Maria and Ponjavic, Vesna and Lövestam Adrian, Monica},
  issn         = {1573-2622},
  keyword      = {Multifocal electroretinogram (mfERG),Diabetic retinopathy,Fluorescein angiogram (FA),Foveal avascular zone (FAZ)},
  language     = {eng},
  pages        = {185--189},
  publisher    = {Springer},
  series       = {Documenta Ophthalmologica},
  title        = {Multifocal electroretinogram (mfERG) in patients with diabetes mellitus and an enlarged foveal avascular zone (FAZ)},
  url          = {http://dx.doi.org/10.1007/s10633-008-9120-2},
  volume       = {117},
  year         = {2008},
}