Advanced

Pathogenomics: An updated European Research Agenda

Demuth, Andreas; Aharonowitz, Yair; Bachmann, Till T; Blum-Oehler, Gabriele; Buchrieser, Carmen; Covacci, Antonello; Dobrindt, Ulrich; Emody, Levente; van der Ende, Arie and Ewbank, Jonathan, et al. (2008) In Infection, Genetics and Evolution 8(3). p.386-393
Abstract
The emerging genomic technologies and bioinformatics provide novel opportunities for studying life-threatening human pathogens and to develop new applications for the improvement of human and animal health and the prevention, treatment, and diagnosis of infections. Based on the ecology and population biology of pathogens and related organisms and their connection to epidemiology, more accurate typing technologies and approaches will lead to better means of disease control. The analysis of the genome plasticity and gene pools of pathogenic bacteria including antigenic diversity and antigenic variation results in more effective vaccines and vaccine implementation programs. The study of newly identified and uncultivated microorganisms enables... (More)
The emerging genomic technologies and bioinformatics provide novel opportunities for studying life-threatening human pathogens and to develop new applications for the improvement of human and animal health and the prevention, treatment, and diagnosis of infections. Based on the ecology and population biology of pathogens and related organisms and their connection to epidemiology, more accurate typing technologies and approaches will lead to better means of disease control. The analysis of the genome plasticity and gene pools of pathogenic bacteria including antigenic diversity and antigenic variation results in more effective vaccines and vaccine implementation programs. The study of newly identified and uncultivated microorganisms enables the identification of new threats. The scrutiny of the metabolism of the pathogen in the host allows the identification of new targets for anti-infectives and therapeutic approaches. The development of modulators of host responses and mediators of host damage will be facilitated by the research on interactions of microbes and hosts, including mechanisms of host damage, acute and chronic relationships as well as commensalisms. The study of multiple pathogenic and non-pathogenic microbes interacting in the host will improve the management of multiple infections and will allow probiotic and prebiotic interventions. Needless to iterate, the application of the results of improved prevention and treatment of infections into clinical tests will have a positive impact on the management of human and animal disease. The Pathogenomics Research Agenda draws on discussions with experts of the Network of Excellence "EuroPathoGenomics" at the management board meeting of the project held during 18-21 April 2007, in the Villa Vigoni, Menaggio, Italy. Based on a proposed European Research Agenda in the field of pathogenomics by the ERA-NET PathoGenoMics the meeting's participants updated the established list of topics as the research agenda for the future. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Microbe–microbe interactions, Antibiotic resistances, Comparative genomics, Bacterial pathogens, Host–microbe interactions
in
Infection, Genetics and Evolution
volume
8
issue
3
pages
386 - 393
publisher
Elsevier
external identifiers
  • pmid:18321793
  • wos:000256289400021
  • scopus:43049093690
ISSN
1567-7257
DOI
10.1016/j.meegid.2008.01.005
language
English
LU publication?
yes
id
000f98de-ceea-41e2-94b3-2bfc4e126e1d (old id 1144658)
date added to LUP
2008-08-14 16:34:07
date last changed
2017-01-01 05:14:22
@article{000f98de-ceea-41e2-94b3-2bfc4e126e1d,
  abstract     = {The emerging genomic technologies and bioinformatics provide novel opportunities for studying life-threatening human pathogens and to develop new applications for the improvement of human and animal health and the prevention, treatment, and diagnosis of infections. Based on the ecology and population biology of pathogens and related organisms and their connection to epidemiology, more accurate typing technologies and approaches will lead to better means of disease control. The analysis of the genome plasticity and gene pools of pathogenic bacteria including antigenic diversity and antigenic variation results in more effective vaccines and vaccine implementation programs. The study of newly identified and uncultivated microorganisms enables the identification of new threats. The scrutiny of the metabolism of the pathogen in the host allows the identification of new targets for anti-infectives and therapeutic approaches. The development of modulators of host responses and mediators of host damage will be facilitated by the research on interactions of microbes and hosts, including mechanisms of host damage, acute and chronic relationships as well as commensalisms. The study of multiple pathogenic and non-pathogenic microbes interacting in the host will improve the management of multiple infections and will allow probiotic and prebiotic interventions. Needless to iterate, the application of the results of improved prevention and treatment of infections into clinical tests will have a positive impact on the management of human and animal disease. The Pathogenomics Research Agenda draws on discussions with experts of the Network of Excellence "EuroPathoGenomics" at the management board meeting of the project held during 18-21 April 2007, in the Villa Vigoni, Menaggio, Italy. Based on a proposed European Research Agenda in the field of pathogenomics by the ERA-NET PathoGenoMics the meeting's participants updated the established list of topics as the research agenda for the future.},
  author       = {Demuth, Andreas and Aharonowitz, Yair and Bachmann, Till T and Blum-Oehler, Gabriele and Buchrieser, Carmen and Covacci, Antonello and Dobrindt, Ulrich and Emody, Levente and van der Ende, Arie and Ewbank, Jonathan and Fernandez, Luis Ángel and Frosch, Mattias and García-del Portillo, Francisco and Gilmore, Michael S and Glaser, Philippe and Goebel, Werner and Hasnain, Seyed E and Heesemann, Jürgen and Islam, Khalid and Korhonen, Timo and Maiden, Martin and Meyer, Thomas F and Montecucco, Cesare and Oswald, Eric and Parkhill, Julian and Pucciarelli, M Graciela and Ron, Eliora and Svanborg, Catharina and Uhlin, Bernt Eric and Nyunt Wai, Sun and Wehland, Jürgen and Hacker, Jörg},
  issn         = {1567-7257},
  keyword      = {Microbe–microbe interactions,Antibiotic resistances,Comparative genomics,Bacterial pathogens,Host–microbe interactions},
  language     = {eng},
  number       = {3},
  pages        = {386--393},
  publisher    = {Elsevier},
  series       = {Infection, Genetics and Evolution},
  title        = {Pathogenomics: An updated European Research Agenda},
  url          = {http://dx.doi.org/10.1016/j.meegid.2008.01.005},
  volume       = {8},
  year         = {2008},
}