Reliability and construct validity of the compatible MRI scoring system for evaluation of elbows in haemophilic children.
(2008) In Haemophilia 14(2). p.303-314- Abstract
- Summary. We assessed the reliability and construct validity of the Compatible MRI scale for evaluation of elbows, and compared the diagnostic performance of MRI and radiographs for assessment of these joints. Twenty-nine MR examinations of elbows from 27 boys with haemophilia A and B [age range, 5–17 years (mean, 11.5)] were independently read by four blinded radiologists on two occasions. Three centres participated in the study: (Toronto, n = 24 examinations; Atlanta, n = 3; Cuiaba, n = 2). The number of previous joint bleeds and severity of haemophilia were reference standard measures. The inter-reader reliability of MRI scores was substantial (ICC = 0.73) for the additive (A)-scale and excellent (ICC = 0.83) for the progressive... (More)
- Summary. We assessed the reliability and construct validity of the Compatible MRI scale for evaluation of elbows, and compared the diagnostic performance of MRI and radiographs for assessment of these joints. Twenty-nine MR examinations of elbows from 27 boys with haemophilia A and B [age range, 5–17 years (mean, 11.5)] were independently read by four blinded radiologists on two occasions. Three centres participated in the study: (Toronto, n = 24 examinations; Atlanta, n = 3; Cuiaba, n = 2). The number of previous joint bleeds and severity of haemophilia were reference standard measures. The inter-reader reliability of MRI scores was substantial (ICC = 0.73) for the additive (A)-scale and excellent (ICC = 0.83) for the progressive (P)-scale. The intrareader reliability was excellent for both P-scores (ICC = 0.91) and A-scores (ICC = 0.93). The total P- and A-scores correlated poorly (r = 0.36) or moderately (r = 0.54), but positively, with clinical-laboratory measurements. The total MRI scores demonstrated high accuracy for discrimination of presence or absence of arthropathy [P-scale, area-under-the-curve (AUC) = 0.94 ± 0.05; A-scale, AUC = 0.89 ± 0.06], as did the soft tissue scores of both scales (P-scale, AUC = 0.90 ± 0.06; A-scale, AUC = 0.86 ± 0.06). Areas-under-the-curve used to discriminate severe disease demonstrated high accuracy for both P-MRI scores (AUC = 0.83 ± 0.09) and A-MRI scores (AUC = 0.87 ± 0.09), but non-diagnostic ability to discriminate mild disease. Similar results were noted for radiographic scales. In conclusion, both MRI scales demonstrated substantial to excellent reliability and accuracy for discrimination of presence/absence of arthropathy, and severe/non-severe disease, but poor to moderate convergent validity for total scores and non-diagnostic discriminant validity for mild/non-mild disease. Compared with radiographic scores, MRI scales did not perform better for discrimination of severity of arthropathy. (Less)
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https://lup.lub.lu.se/record/1144752
- author
- Doria, A S ; Lundin, Björn LU ; Miller, S ; Kilcoyne, R ; Dunn, A ; Thomas, S ; Rivard, G ; Moineddin, R ; Babyn, P S and Expert Imaging Working Group of the International Prophylaxis Study Group, and
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- validity, scoring systems, reliability, progressive, magnetic resonance imaging, haemophilia, children, arthropathy, additive
- in
- Haemophilia
- volume
- 14
- issue
- 2
- pages
- 303 - 314
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000253626100011
- scopus:40349100415
- pmid:18179575
- ISSN
- 1351-8216
- DOI
- 10.1111/j.1365-2516.2007.01602.x
- language
- English
- LU publication?
- yes
- id
- 8533420a-a130-4483-b35a-ab9bf07c2e59 (old id 1144752)
- date added to LUP
- 2016-04-04 12:19:49
- date last changed
- 2022-08-01 08:29:19
@article{8533420a-a130-4483-b35a-ab9bf07c2e59,
abstract = {{Summary. We assessed the reliability and construct validity of the Compatible MRI scale for evaluation of elbows, and compared the diagnostic performance of MRI and radiographs for assessment of these joints. Twenty-nine MR examinations of elbows from 27 boys with haemophilia A and B [age range, 5–17 years (mean, 11.5)] were independently read by four blinded radiologists on two occasions. Three centres participated in the study: (Toronto, n = 24 examinations; Atlanta, n = 3; Cuiaba, n = 2). The number of previous joint bleeds and severity of haemophilia were reference standard measures. The inter-reader reliability of MRI scores was substantial (ICC = 0.73) for the additive (A)-scale and excellent (ICC = 0.83) for the progressive (P)-scale. The intrareader reliability was excellent for both P-scores (ICC = 0.91) and A-scores (ICC = 0.93). The total P- and A-scores correlated poorly (r = 0.36) or moderately (r = 0.54), but positively, with clinical-laboratory measurements. The total MRI scores demonstrated high accuracy for discrimination of presence or absence of arthropathy [P-scale, area-under-the-curve (AUC) = 0.94 ± 0.05; A-scale, AUC = 0.89 ± 0.06], as did the soft tissue scores of both scales (P-scale, AUC = 0.90 ± 0.06; A-scale, AUC = 0.86 ± 0.06). Areas-under-the-curve used to discriminate severe disease demonstrated high accuracy for both P-MRI scores (AUC = 0.83 ± 0.09) and A-MRI scores (AUC = 0.87 ± 0.09), but non-diagnostic ability to discriminate mild disease. Similar results were noted for radiographic scales. In conclusion, both MRI scales demonstrated substantial to excellent reliability and accuracy for discrimination of presence/absence of arthropathy, and severe/non-severe disease, but poor to moderate convergent validity for total scores and non-diagnostic discriminant validity for mild/non-mild disease. Compared with radiographic scores, MRI scales did not perform better for discrimination of severity of arthropathy.}},
author = {{Doria, A S and Lundin, Björn and Miller, S and Kilcoyne, R and Dunn, A and Thomas, S and Rivard, G and Moineddin, R and Babyn, P S and Expert Imaging Working Group of the International Prophylaxis Study Group, and}},
issn = {{1351-8216}},
keywords = {{validity; scoring systems; reliability; progressive; magnetic resonance imaging; haemophilia; children; arthropathy; additive}},
language = {{eng}},
number = {{2}},
pages = {{303--314}},
publisher = {{Wiley-Blackwell}},
series = {{Haemophilia}},
title = {{Reliability and construct validity of the compatible MRI scoring system for evaluation of elbows in haemophilic children.}},
url = {{http://dx.doi.org/10.1111/j.1365-2516.2007.01602.x}},
doi = {{10.1111/j.1365-2516.2007.01602.x}},
volume = {{14}},
year = {{2008}},
}