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Pravastatin inhibits pro-inflammatory effects of Alzheimer's peptide Abeta(1-42) in glioma cell culture in vitro.

Sun, Yongxin LU ; Crisby, Milita; Lindgren, Stefan LU and Janciauskiene, Sabina LU (2003) In Pharmacological Research 47(2). p.119-126
Abstract
Statins are known to exert a number of biological effects apart from reducing cholesterol synthesis. The results of recent studies indicate that patients treated with pravastatin have a lower prevalence of diagnosed Alzheimer’s disease (AD). These observations prompted us to examine the effects of pravastatin on Alzheimer’s peptide (Aβ1–42)-induced pro-inflammatory activation in the human glioma cell line in vitro. Cells alone or cells pre-treated with pravastatin (0.1 mg ml−1) for 24 h were stimulated with 5 μM of freshly dissolved Aβ1–42 for the next 24 h. The pre-treatment of cells with pravastatin diminished the capacity of Aβ to induce metalloproteinases, cytokine IL-6 and free radical levels. Although both pravastatin and Aβ1–42... (More)
Statins are known to exert a number of biological effects apart from reducing cholesterol synthesis. The results of recent studies indicate that patients treated with pravastatin have a lower prevalence of diagnosed Alzheimer’s disease (AD). These observations prompted us to examine the effects of pravastatin on Alzheimer’s peptide (Aβ1–42)-induced pro-inflammatory activation in the human glioma cell line in vitro. Cells alone or cells pre-treated with pravastatin (0.1 mg ml−1) for 24 h were stimulated with 5 μM of freshly dissolved Aβ1–42 for the next 24 h. The pre-treatment of cells with pravastatin diminished the capacity of Aβ to induce metalloproteinases, cytokine IL-6 and free radical levels. Although both pravastatin and Aβ1–42 separately increased PPARγ activity, the combination of Aβ1–42 and pravastatin resulted in no effect on PPARγ expression. These data indicate that soluble forms of Aβ1–42, which are a potent stimulus of pro-inflammatory activation of glioma cells in vitro, could be a good target for pravastatin. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer’s disease, Alzheimer’s peptide, Pravastatin, Inflammation
in
Pharmacological Research
volume
47
issue
2
pages
119 - 126
publisher
Academic Press
external identifiers
  • pmid:12543059
  • wos:000180923900003
  • scopus:0037331420
ISSN
1096-1186
DOI
10.1016/S1043-6618(02)00288-8
language
English
LU publication?
yes
id
fb5ec335-a793-468d-82d6-368dd19c328b (old id 114503)
date added to LUP
2007-07-30 10:37:37
date last changed
2018-10-04 13:49:08
@article{fb5ec335-a793-468d-82d6-368dd19c328b,
  abstract     = {Statins are known to exert a number of biological effects apart from reducing cholesterol synthesis. The results of recent studies indicate that patients treated with pravastatin have a lower prevalence of diagnosed Alzheimer’s disease (AD). These observations prompted us to examine the effects of pravastatin on Alzheimer’s peptide (Aβ1–42)-induced pro-inflammatory activation in the human glioma cell line in vitro. Cells alone or cells pre-treated with pravastatin (0.1 mg ml−1) for 24 h were stimulated with 5 μM of freshly dissolved Aβ1–42 for the next 24 h. The pre-treatment of cells with pravastatin diminished the capacity of Aβ to induce metalloproteinases, cytokine IL-6 and free radical levels. Although both pravastatin and Aβ1–42 separately increased PPARγ activity, the combination of Aβ1–42 and pravastatin resulted in no effect on PPARγ expression. These data indicate that soluble forms of Aβ1–42, which are a potent stimulus of pro-inflammatory activation of glioma cells in vitro, could be a good target for pravastatin.},
  author       = {Sun, Yongxin and Crisby, Milita and Lindgren, Stefan and Janciauskiene, Sabina},
  issn         = {1096-1186},
  keyword      = {Alzheimer’s disease,Alzheimer’s peptide,Pravastatin,Inflammation},
  language     = {eng},
  number       = {2},
  pages        = {119--126},
  publisher    = {Academic Press},
  series       = {Pharmacological Research},
  title        = {Pravastatin inhibits pro-inflammatory effects of Alzheimer's peptide Abeta(1-42) in glioma cell culture in vitro.},
  url          = {http://dx.doi.org/10.1016/S1043-6618(02)00288-8},
  volume       = {47},
  year         = {2003},
}