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Blood pressure increase and incidence of hypertension in relation to inflammation-sensitive plasma proteins.

Engström, Gunnar LU ; Janzon, Lars LU ; Berglund, Göran LU ; Lind, Peter; Stavenow, Lars; Hedblad, Bo LU and Lindgärde, Folke LU (2002) In Arteriosclerosis, Thrombosis and Vascular Biology 22(12). p.2054-2058
Abstract
Objective— The reasons for the relationship between inflammation-sensitive plasma proteins (ISPs) and incidence of cardiovascular diseases are poorly understood. This study explored the hypothesis that ISPs are associated with future hypertension and age-related blood pressure increase.



Method and Results— Blood pressure and plasma levels of fibrinogen, {alpha}1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were determined in 2262 healthy men aged 35 to 50 years, initially without treatment for hypertension. The cohort was re-examined after 15.7 (±2.2) years. Incidence of hypertension and blood pressure increase was studied in relation to number of elevated proteins (ie, in the top quartile) at baseline. Among... (More)
Objective— The reasons for the relationship between inflammation-sensitive plasma proteins (ISPs) and incidence of cardiovascular diseases are poorly understood. This study explored the hypothesis that ISPs are associated with future hypertension and age-related blood pressure increase.



Method and Results— Blood pressure and plasma levels of fibrinogen, {alpha}1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were determined in 2262 healthy men aged 35 to 50 years, initially without treatment for hypertension. The cohort was re-examined after 15.7 (±2.2) years. Incidence of hypertension and blood pressure increase was studied in relation to number of elevated proteins (ie, in the top quartile) at baseline. Among men without treatment for hypertension at follow-up, mean (±SD) increase in systolic blood pressure was 18.8±17, 19.2±17, 19.3±17, and 22.1±18 mm Hg, respectively, for men with 0, 1, 2, and >=3 elevated proteins (P for trend=0.02, adjusted for confounders). The corresponding values for pulse pressure increase was 15.5±14, 15.8±14, 17.4±14, and 17.8±15 mm Hg, respectively (P=0.02). Incidence of hypertension (>=160/95 mm Hg or treatment) and future blood pressure treatment showed similar associations with ISPs. Increase in diastolic blood pressure showed no association with ISPs.



Conclusions— Plasma levels of ISPs are associated with a future increase in blood pressure. This could contribute to the relationship between ISP levels and cardiovascular disease. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
Hypertension: physiopathology, Hypertension: pathology, Hypertension: epidemiology, Hypertension: blood, Human, Follow-Up Studies, Non-U.S. Gov't, Cohort Studies, Blood Proteins: physiology, Blood Pressure: physiology, Antihypertensive Agents: therapeutic use, Aged, Age Factors, Systole: physiology, Adult, Incidence, Inflammation: blood, Inflammation: physiopathology, Male, Middle Age, Multivariate Analysis, Support
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
22
issue
12
pages
2054 - 2058
publisher
American Heart Association
external identifiers
  • wos:000180046000020
  • pmid:12482834
  • scopus:0036920207
ISSN
1524-4636
DOI
10.1161/01.ATV.0000041842.43905.F3
language
English
LU publication?
yes
id
7b83a47a-cc10-4e3c-b24a-e805a1ae319c (old id 114618)
date added to LUP
2007-07-18 14:51:13
date last changed
2017-12-10 03:56:35
@article{7b83a47a-cc10-4e3c-b24a-e805a1ae319c,
  abstract     = {Objective— The reasons for the relationship between inflammation-sensitive plasma proteins (ISPs) and incidence of cardiovascular diseases are poorly understood. This study explored the hypothesis that ISPs are associated with future hypertension and age-related blood pressure increase.<br/><br>
<br/><br>
Method and Results— Blood pressure and plasma levels of fibrinogen, {alpha}1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were determined in 2262 healthy men aged 35 to 50 years, initially without treatment for hypertension. The cohort was re-examined after 15.7 (±2.2) years. Incidence of hypertension and blood pressure increase was studied in relation to number of elevated proteins (ie, in the top quartile) at baseline. Among men without treatment for hypertension at follow-up, mean (±SD) increase in systolic blood pressure was 18.8±17, 19.2±17, 19.3±17, and 22.1±18 mm Hg, respectively, for men with 0, 1, 2, and &gt;=3 elevated proteins (P for trend=0.02, adjusted for confounders). The corresponding values for pulse pressure increase was 15.5±14, 15.8±14, 17.4±14, and 17.8±15 mm Hg, respectively (P=0.02). Incidence of hypertension (&gt;=160/95 mm Hg or treatment) and future blood pressure treatment showed similar associations with ISPs. Increase in diastolic blood pressure showed no association with ISPs.<br/><br>
<br/><br>
Conclusions— Plasma levels of ISPs are associated with a future increase in blood pressure. This could contribute to the relationship between ISP levels and cardiovascular disease.},
  author       = {Engström, Gunnar and Janzon, Lars and Berglund, Göran and Lind, Peter and Stavenow, Lars and Hedblad, Bo and Lindgärde, Folke},
  issn         = {1524-4636},
  keyword      = {Hypertension: physiopathology,Hypertension: pathology,Hypertension: epidemiology,Hypertension: blood,Human,Follow-Up Studies,Non-U.S. Gov't,Cohort Studies,Blood Proteins: physiology,Blood Pressure: physiology,Antihypertensive Agents: therapeutic use,Aged,Age Factors,Systole: physiology,Adult,Incidence,Inflammation: blood,Inflammation: physiopathology,Male,Middle Age,Multivariate Analysis,Support},
  language     = {eng},
  number       = {12},
  pages        = {2054--2058},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Blood pressure increase and incidence of hypertension in relation to inflammation-sensitive plasma proteins.},
  url          = {http://dx.doi.org/10.1161/01.ATV.0000041842.43905.F3},
  volume       = {22},
  year         = {2002},
}