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Long-term effects of inflammation-sensitive plasma proteins and systolic blood pressure on incidence of stroke.

Engström, Gunnar LU ; Lind, P; Hedblad, Bo LU ; Stavenow, L; Janzon, Lars LU and Lindgärde, Folke LU (2002) In Stroke: a journal of cerebral circulation 33(12). p.2744-2749
Abstract
Background and Purpose— The present study investigated the relationships between inflammation-sensitive plasma proteins (ISPs) and systolic blood pressure (SBP), as well as the joint long-term effects of ISP and SBP on incidence of stroke.



Methods— BP and 5 ISPs (fibrinogen, {alpha}1-antitrypsin, haptoglobin, ceruloplasmin, orosomucoid) were assessed in 6071 healthy men 28 to 61 years of age. All-cause mortality and incidence of stroke were monitored over a mean follow-up of 18.7 years in men defined by SBP (<120, 120 to 139, >=140 mm Hg) and ISP (0 to 1 or 2 to 5 ISPs in the top quartile).



Results— SBP and diastolic BP were significantly and positively associated with the number of ISPs in the... (More)
Background and Purpose— The present study investigated the relationships between inflammation-sensitive plasma proteins (ISPs) and systolic blood pressure (SBP), as well as the joint long-term effects of ISP and SBP on incidence of stroke.



Methods— BP and 5 ISPs (fibrinogen, {alpha}1-antitrypsin, haptoglobin, ceruloplasmin, orosomucoid) were assessed in 6071 healthy men 28 to 61 years of age. All-cause mortality and incidence of stroke were monitored over a mean follow-up of 18.7 years in men defined by SBP (<120, 120 to 139, >=140 mm Hg) and ISP (0 to 1 or 2 to 5 ISPs in the top quartile).



Results— SBP and diastolic BP were significantly and positively associated with the number of ISPs in the top quartile. As expected, elevated SBP was associated with an increased incidence of stroke. Among men with SBP >=140 mm Hg, there were, however, significant differences between those with high and low ISP levels. After risk factor adjustment, men with SBP >=140 mm Hg and high ISP levels had a relative risk of stroke of 4.3 (95% CI, 2.3 to 7.8) compared with men with SBP <120 mm Hg and low ISP levels. In the absence of high ISP levels, the risk associated with SBP >=140 was 2.5 (95% CI,1.4 to 4.6). Men with high ISP levels had a significantly increased risk of stroke also after exclusion of the events from the first 10 years of follow-up.



Conclusions— High ISP levels are associated with elevated BP. These proteins are associated with an increased risk of stroke among men with high BP and provide information on stroke risk even after many years of follow-up. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Orosomucoid: analysis, Middle Age, Male, Inflammation: blood, Incidence, Hypertension: mortality, Hypertension: blood, Human, Fibrinogen: analysis, Diastole, Comorbidity, Ceruloplasmin: analysis, Cerebrovascular Accident: mortality, Cerebrovascular Accident: blood, Blood Proteins: analysis, Blood Pressure: physiology, Adult, Follow-Up Studies, Haptoglobins: analysis, Predictive Value of Tests, Risk Assessment, Risk Factors, Support, Non-U.S. Gov't, Sweden: epidemiology, Systole, Time, alpha 1-Antitrypsin: analysis
in
Stroke: a journal of cerebral circulation
volume
33
issue
12
pages
2744 - 2749
publisher
American Heart Association
external identifiers
  • pmid:12468764
  • wos:000179827100010
  • scopus:0036903346
ISSN
1524-4628
DOI
10.1161/01.STR.0000034787.02925.1F
language
English
LU publication?
yes
id
8cc96fb5-f353-4d5c-9c46-8f268197a852 (old id 114666)
date added to LUP
2007-07-18 14:39:12
date last changed
2017-07-30 04:33:43
@article{8cc96fb5-f353-4d5c-9c46-8f268197a852,
  abstract     = {Background and Purpose— The present study investigated the relationships between inflammation-sensitive plasma proteins (ISPs) and systolic blood pressure (SBP), as well as the joint long-term effects of ISP and SBP on incidence of stroke.<br/><br>
<br/><br>
Methods— BP and 5 ISPs (fibrinogen, {alpha}1-antitrypsin, haptoglobin, ceruloplasmin, orosomucoid) were assessed in 6071 healthy men 28 to 61 years of age. All-cause mortality and incidence of stroke were monitored over a mean follow-up of 18.7 years in men defined by SBP (&lt;120, 120 to 139, &gt;=140 mm Hg) and ISP (0 to 1 or 2 to 5 ISPs in the top quartile).<br/><br>
<br/><br>
Results— SBP and diastolic BP were significantly and positively associated with the number of ISPs in the top quartile. As expected, elevated SBP was associated with an increased incidence of stroke. Among men with SBP &gt;=140 mm Hg, there were, however, significant differences between those with high and low ISP levels. After risk factor adjustment, men with SBP &gt;=140 mm Hg and high ISP levels had a relative risk of stroke of 4.3 (95% CI, 2.3 to 7.8) compared with men with SBP &lt;120 mm Hg and low ISP levels. In the absence of high ISP levels, the risk associated with SBP &gt;=140 was 2.5 (95% CI,1.4 to 4.6). Men with high ISP levels had a significantly increased risk of stroke also after exclusion of the events from the first 10 years of follow-up.<br/><br>
<br/><br>
Conclusions— High ISP levels are associated with elevated BP. These proteins are associated with an increased risk of stroke among men with high BP and provide information on stroke risk even after many years of follow-up.},
  author       = {Engström, Gunnar and Lind, P and Hedblad, Bo and Stavenow, L and Janzon, Lars and Lindgärde, Folke},
  issn         = {1524-4628},
  keyword      = {Orosomucoid: analysis,Middle Age,Male,Inflammation: blood,Incidence,Hypertension: mortality,Hypertension: blood,Human,Fibrinogen: analysis,Diastole,Comorbidity,Ceruloplasmin: analysis,Cerebrovascular Accident: mortality,Cerebrovascular Accident: blood,Blood Proteins: analysis,Blood Pressure: physiology,Adult,Follow-Up Studies,Haptoglobins: analysis,Predictive Value of Tests,Risk Assessment,Risk Factors,Support,Non-U.S. Gov't,Sweden: epidemiology,Systole,Time,alpha 1-Antitrypsin: analysis},
  language     = {eng},
  number       = {12},
  pages        = {2744--2749},
  publisher    = {American Heart Association},
  series       = { Stroke: a journal of cerebral circulation},
  title        = {Long-term effects of inflammation-sensitive plasma proteins and systolic blood pressure on incidence of stroke.},
  url          = {http://dx.doi.org/10.1161/01.STR.0000034787.02925.1F},
  volume       = {33},
  year         = {2002},
}