Cerebrovascular Angiotensin AT(1) Receptor Regulation in Cerebral Ischemia.
(2008) In Trends in Cardiovascular Medicine 18(3). p.98-103- Abstract
- The mechanism behind the positive response to the inhibition of the angiotensin II receptor AT(1) in conjunction with stroke is elusive. Here we demonstrate that cerebrovascular AT(1) receptors show increased expression (upregulation) after cerebral ischemia via enhanced translation. This enhanced expression of AT(1) receptors occurs in the ischemic cerebral arteries and microvessels, and their inhibition results in a reduction in infarct volume. These findings add to the understanding of the vascular component in stroke, and the identified inhibition provides a new way to reduce the extent of cerebral ischemic damage.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1147077
- author
- Edvinsson, Lars LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Cardiovascular Medicine
- volume
- 18
- issue
- 3
- pages
- 98 - 103
- publisher
- Elsevier
- external identifiers
-
- wos:000255675100005
- pmid:18436148
- scopus:43049100001
- pmid:18436148
- ISSN
- 1873-2615
- DOI
- 10.1016/j.tcm.2008.01.005
- language
- English
- LU publication?
- yes
- id
- 879d3496-5120-48d9-97dd-b3993b5982b4 (old id 1147077)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18436148?dopt=Abstract
- date added to LUP
- 2016-04-04 08:54:08
- date last changed
- 2024-10-12 19:27:10
@article{879d3496-5120-48d9-97dd-b3993b5982b4,
abstract = {{The mechanism behind the positive response to the inhibition of the angiotensin II receptor AT(1) in conjunction with stroke is elusive. Here we demonstrate that cerebrovascular AT(1) receptors show increased expression (upregulation) after cerebral ischemia via enhanced translation. This enhanced expression of AT(1) receptors occurs in the ischemic cerebral arteries and microvessels, and their inhibition results in a reduction in infarct volume. These findings add to the understanding of the vascular component in stroke, and the identified inhibition provides a new way to reduce the extent of cerebral ischemic damage.}},
author = {{Edvinsson, Lars}},
issn = {{1873-2615}},
language = {{eng}},
number = {{3}},
pages = {{98--103}},
publisher = {{Elsevier}},
series = {{Trends in Cardiovascular Medicine}},
title = {{Cerebrovascular Angiotensin AT(1) Receptor Regulation in Cerebral Ischemia.}},
url = {{http://dx.doi.org/10.1016/j.tcm.2008.01.005}},
doi = {{10.1016/j.tcm.2008.01.005}},
volume = {{18}},
year = {{2008}},
}