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Cerebrovascular Angiotensin AT(1) Receptor Regulation in Cerebral Ischemia.

Edvinsson, Lars LU (2008) In Trends in Cardiovascular Medicine 18(3). p.98-103
Abstract
The mechanism behind the positive response to the inhibition of the angiotensin II receptor AT(1) in conjunction with stroke is elusive. Here we demonstrate that cerebrovascular AT(1) receptors show increased expression (upregulation) after cerebral ischemia via enhanced translation. This enhanced expression of AT(1) receptors occurs in the ischemic cerebral arteries and microvessels, and their inhibition results in a reduction in infarct volume. These findings add to the understanding of the vascular component in stroke, and the identified inhibition provides a new way to reduce the extent of cerebral ischemic damage.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Cardiovascular Medicine
volume
18
issue
3
pages
98 - 103
publisher
Elsevier
external identifiers
  • wos:000255675100005
  • pmid:18436148
  • scopus:43049100001
ISSN
1873-2615
DOI
10.1016/j.tcm.2008.01.005
language
English
LU publication?
yes
id
879d3496-5120-48d9-97dd-b3993b5982b4 (old id 1147077)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18436148?dopt=Abstract
date added to LUP
2008-05-08 09:36:13
date last changed
2017-01-01 07:39:39
@article{879d3496-5120-48d9-97dd-b3993b5982b4,
  abstract     = {The mechanism behind the positive response to the inhibition of the angiotensin II receptor AT(1) in conjunction with stroke is elusive. Here we demonstrate that cerebrovascular AT(1) receptors show increased expression (upregulation) after cerebral ischemia via enhanced translation. This enhanced expression of AT(1) receptors occurs in the ischemic cerebral arteries and microvessels, and their inhibition results in a reduction in infarct volume. These findings add to the understanding of the vascular component in stroke, and the identified inhibition provides a new way to reduce the extent of cerebral ischemic damage.},
  author       = {Edvinsson, Lars},
  issn         = {1873-2615},
  language     = {eng},
  number       = {3},
  pages        = {98--103},
  publisher    = {Elsevier},
  series       = {Trends in Cardiovascular Medicine},
  title        = {Cerebrovascular Angiotensin AT(1) Receptor Regulation in Cerebral Ischemia.},
  url          = {http://dx.doi.org/10.1016/j.tcm.2008.01.005},
  volume       = {18},
  year         = {2008},
}