Biophysics of viral infectivity: matching genome length with capsid size.
(2007) In Quarterly Reviews of Biophysics 40(4). p.327-356- Abstract
- In this review, we discuss recent advances in biophysical virology, presenting experimental and theoretical studies on the physical properties of viruses. We focus on the double-stranded (ds) DNA bacteriophages as model systems for all of the dsDNA viruses both prokaryotic and eukaryotic. Recent studies demonstrate that the DNA packaged into a viral capsid is highly pressurized, which provides a force for the first step of passive injection of viral DNA into a bacterial cell. Moreover, specific studies on capsid strength show a strong correlation between genome length, and capsid size and robustness. The implications of these newly appreciated physical properties of a viral particle with respect to the infection process are discussed.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1147257
- author
- Nurmemmedov, Elmar LU ; Castelnovo, Martin ; Catalano, Carlos Enrique and Evilevitch, Alex LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Quarterly Reviews of Biophysics
- volume
- 40
- issue
- 4
- pages
- 327 - 356
- publisher
- Cambridge University Press
- external identifiers
-
- wos:000256108100002
- pmid:18423102
- scopus:42449112829
- ISSN
- 1469-8994
- DOI
- 10.1017/S0033583508004666
- language
- English
- LU publication?
- yes
- id
- cd940af2-bf70-4100-83b3-4291de2e2b2b (old id 1147257)
- date added to LUP
- 2016-04-01 15:38:58
- date last changed
- 2022-01-28 06:22:06
@article{cd940af2-bf70-4100-83b3-4291de2e2b2b, abstract = {{In this review, we discuss recent advances in biophysical virology, presenting experimental and theoretical studies on the physical properties of viruses. We focus on the double-stranded (ds) DNA bacteriophages as model systems for all of the dsDNA viruses both prokaryotic and eukaryotic. Recent studies demonstrate that the DNA packaged into a viral capsid is highly pressurized, which provides a force for the first step of passive injection of viral DNA into a bacterial cell. Moreover, specific studies on capsid strength show a strong correlation between genome length, and capsid size and robustness. The implications of these newly appreciated physical properties of a viral particle with respect to the infection process are discussed.}}, author = {{Nurmemmedov, Elmar and Castelnovo, Martin and Catalano, Carlos Enrique and Evilevitch, Alex}}, issn = {{1469-8994}}, language = {{eng}}, number = {{4}}, pages = {{327--356}}, publisher = {{Cambridge University Press}}, series = {{Quarterly Reviews of Biophysics}}, title = {{Biophysics of viral infectivity: matching genome length with capsid size.}}, url = {{http://dx.doi.org/10.1017/S0033583508004666}}, doi = {{10.1017/S0033583508004666}}, volume = {{40}}, year = {{2007}}, }