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Biophysics of viral infectivity: matching genome length with capsid size.

Nurmemmedov, Elmar LU ; Castelnovo, Martin; Catalano, Carlos Enrique and Evilevitch, Alex LU (2007) In Quarterly Reviews of Biophysics 40(4). p.327-356
Abstract
In this review, we discuss recent advances in biophysical virology, presenting experimental and theoretical studies on the physical properties of viruses. We focus on the double-stranded (ds) DNA bacteriophages as model systems for all of the dsDNA viruses both prokaryotic and eukaryotic. Recent studies demonstrate that the DNA packaged into a viral capsid is highly pressurized, which provides a force for the first step of passive injection of viral DNA into a bacterial cell. Moreover, specific studies on capsid strength show a strong correlation between genome length, and capsid size and robustness. The implications of these newly appreciated physical properties of a viral particle with respect to the infection process are discussed.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Quarterly Reviews of Biophysics
volume
40
issue
4
pages
327 - 356
publisher
Cambridge University Press
external identifiers
  • wos:000256108100002
  • pmid:18423102
  • scopus:42449112829
ISSN
1469-8994
DOI
10.1017/S0033583508004666
language
English
LU publication?
yes
id
cd940af2-bf70-4100-83b3-4291de2e2b2b (old id 1147257)
date added to LUP
2009-03-09 09:30:26
date last changed
2017-02-19 04:06:06
@article{cd940af2-bf70-4100-83b3-4291de2e2b2b,
  abstract     = {In this review, we discuss recent advances in biophysical virology, presenting experimental and theoretical studies on the physical properties of viruses. We focus on the double-stranded (ds) DNA bacteriophages as model systems for all of the dsDNA viruses both prokaryotic and eukaryotic. Recent studies demonstrate that the DNA packaged into a viral capsid is highly pressurized, which provides a force for the first step of passive injection of viral DNA into a bacterial cell. Moreover, specific studies on capsid strength show a strong correlation between genome length, and capsid size and robustness. The implications of these newly appreciated physical properties of a viral particle with respect to the infection process are discussed.},
  author       = {Nurmemmedov, Elmar and Castelnovo, Martin and Catalano, Carlos Enrique and Evilevitch, Alex},
  issn         = {1469-8994},
  language     = {eng},
  number       = {4},
  pages        = {327--356},
  publisher    = {Cambridge University Press},
  series       = {Quarterly Reviews of Biophysics},
  title        = {Biophysics of viral infectivity: matching genome length with capsid size.},
  url          = {http://dx.doi.org/10.1017/S0033583508004666},
  volume       = {40},
  year         = {2007},
}