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Insulin, intracerebral glucose and bedside biochemical monitoring utilizing microdialysis.

Nordström, Carl-Henrik LU (2008) In Critical Care 12(2).
Abstract
ABSTRACT: Following subarachnoid hemorrhage, hyperglycemia is strongly associated with complications and with impaired neurological recovery. Targeted insulin therapy for glycemic control might, on the contrary, have harmful effects by causing too low cerebral glucose levels. The study published by Schlenk and colleagues in the previous issue of Critical Care shows that insulin caused a significant decrease in the interstitial cerebral glucose concentration although the blood glucose level remained unaffected. Since several studies utilizing various analytical techniques have shown that cerebral blood flow and cerebral glucose uptake and metabolism are insulin-independent processes, the observation remains unexplained.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Critical Care
volume
12
issue
2
publisher
BioMed Central
external identifiers
  • wos:000257632900041
  • pmid:18423062
  • scopus:54049106942
ISSN
1364-8535
DOI
10.1186/cc6826
language
English
LU publication?
yes
id
95bb4250-7d50-4068-9e24-dab5da140876 (old id 1147264)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18423062?dopt=Abstract
date added to LUP
2008-05-06 14:37:09
date last changed
2017-01-01 07:40:45
@article{95bb4250-7d50-4068-9e24-dab5da140876,
  abstract     = {ABSTRACT: Following subarachnoid hemorrhage, hyperglycemia is strongly associated with complications and with impaired neurological recovery. Targeted insulin therapy for glycemic control might, on the contrary, have harmful effects by causing too low cerebral glucose levels. The study published by Schlenk and colleagues in the previous issue of Critical Care shows that insulin caused a significant decrease in the interstitial cerebral glucose concentration although the blood glucose level remained unaffected. Since several studies utilizing various analytical techniques have shown that cerebral blood flow and cerebral glucose uptake and metabolism are insulin-independent processes, the observation remains unexplained.},
  articleno    = {124},
  author       = {Nordström, Carl-Henrik},
  issn         = {1364-8535},
  language     = {eng},
  number       = {2},
  publisher    = {BioMed Central},
  series       = {Critical Care},
  title        = {Insulin, intracerebral glucose and bedside biochemical monitoring utilizing microdialysis.},
  url          = {http://dx.doi.org/10.1186/cc6826},
  volume       = {12},
  year         = {2008},
}