Advanced

Lung function and cardiovascular risk: relationship with inflammation-sensitive plasma proteins.

Engström, Gunnar LU ; Lind, P; Hedblad, Bo LU ; Wollmer, Per LU ; Stavenow, L; Janzon, Lars LU and Lindgärde, Folke LU (2002) In Circulation 106(20). p.2555-2560
Abstract
Background— The inverse relationship between pulmonary function and incidence of cardiovascular disease remains largely unexplained. This prospective study explored the hypothesis of a relationship with inflammation-sensitive plasma proteins.



Methods and Results— Forced vital capacity (FVC) and plasma levels of fibrinogen, {alpha} 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were determined in 5064 healthy men aged 28 to 61 years. All-cause mortality, cardiovascular mortality, and incidence of myocardial infarction were monitored over a mean follow-up period of 18.4 years. Low FVC (fourth quartile) was associated with higher protein levels and with increased incidences of myocardial infarction and... (More)
Background— The inverse relationship between pulmonary function and incidence of cardiovascular disease remains largely unexplained. This prospective study explored the hypothesis of a relationship with inflammation-sensitive plasma proteins.



Methods and Results— Forced vital capacity (FVC) and plasma levels of fibrinogen, {alpha} 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were determined in 5064 healthy men aged 28 to 61 years. All-cause mortality, cardiovascular mortality, and incidence of myocardial infarction were monitored over a mean follow-up period of 18.4 years. Low FVC (fourth quartile) was associated with higher protein levels and with increased incidences of myocardial infarction and cardiovascular death. Adjustments for protein levels reduced the age-adjusted relative risks (RRs) for myocardial infarction (from 1.99, 95% CI 1.5 to 2.6, to 1.70, 95% CI 1.3 to 2.2) and cardiovascular death (from 2.71, 95% CI 1.9 to 3.9, to 2.28, 95% CI 1.6 to 3.3) among men with low FVC, corresponding to {approx}25% of the excess risk. The risk factor–adjusted RRs were reduced from 1.45 (95% CI 1.1 to 1.9) to 1.38 (95% CI 1.1 to 1.8) and from 1.96 (95% CI 1.4 to 2.8) to 1.85 (95% CI 1.3 to 2.7) for myocardial infarction and cardiovascular death, respectively, corresponding to {approx}10% to 15% of the excess risk. Among men with low FVC, the risk factor–adjusted RR for myocardial infarction was 2.5 (95% CI 1.7 to 3.6) for those with high protein levels (>=2 proteins in top quartile) and 1.7 (95% CI 1.1 to 2.4) for those with low protein levels (<=1 protein in top quartile; reference, top quartile of FVC and low protein levels).



Conclusions— FVC is significantly and inversely associated with plasma levels of inflammation-sensitive plasma proteins. This relationship contributes to but cannot fully explain the increased cardiovascular risk among men with low FVC. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Human, Adult, Blood Proteins: analysis, Cardiovascular Diseases: epidemiology, Cardiovascular Diseases: mortality, Cohort Studies, Follow-Up Studies, Inflammation: blood, Male, Myocardial Infarction: epidemiology, Middle Age, Incidence, Vital Capacity, Survival Analysis, Prospective Studies, Risk Factors, Support, Non-U.S. Gov't
in
Circulation
volume
106
issue
20
pages
2555 - 2560
publisher
Lippincott Williams and Wilkins
external identifiers
  • wos:000179339300023
  • pmid:12427651
  • scopus:0037069348
ISSN
1524-4539
DOI
10.1161/01.CIR.0000037220.00065.0D
language
English
LU publication?
yes
id
6a3b745a-c0d2-4c84-adfb-493281880774 (old id 114728)
date added to LUP
2007-07-18 14:28:26
date last changed
2017-12-10 04:37:55
@article{6a3b745a-c0d2-4c84-adfb-493281880774,
  abstract     = {Background— The inverse relationship between pulmonary function and incidence of cardiovascular disease remains largely unexplained. This prospective study explored the hypothesis of a relationship with inflammation-sensitive plasma proteins.<br/><br>
<br/><br>
Methods and Results— Forced vital capacity (FVC) and plasma levels of fibrinogen, {alpha} 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were determined in 5064 healthy men aged 28 to 61 years. All-cause mortality, cardiovascular mortality, and incidence of myocardial infarction were monitored over a mean follow-up period of 18.4 years. Low FVC (fourth quartile) was associated with higher protein levels and with increased incidences of myocardial infarction and cardiovascular death. Adjustments for protein levels reduced the age-adjusted relative risks (RRs) for myocardial infarction (from 1.99, 95% CI 1.5 to 2.6, to 1.70, 95% CI 1.3 to 2.2) and cardiovascular death (from 2.71, 95% CI 1.9 to 3.9, to 2.28, 95% CI 1.6 to 3.3) among men with low FVC, corresponding to {approx}25% of the excess risk. The risk factor–adjusted RRs were reduced from 1.45 (95% CI 1.1 to 1.9) to 1.38 (95% CI 1.1 to 1.8) and from 1.96 (95% CI 1.4 to 2.8) to 1.85 (95% CI 1.3 to 2.7) for myocardial infarction and cardiovascular death, respectively, corresponding to {approx}10% to 15% of the excess risk. Among men with low FVC, the risk factor–adjusted RR for myocardial infarction was 2.5 (95% CI 1.7 to 3.6) for those with high protein levels (&gt;=2 proteins in top quartile) and 1.7 (95% CI 1.1 to 2.4) for those with low protein levels (&lt;=1 protein in top quartile; reference, top quartile of FVC and low protein levels).<br/><br>
<br/><br>
Conclusions— FVC is significantly and inversely associated with plasma levels of inflammation-sensitive plasma proteins. This relationship contributes to but cannot fully explain the increased cardiovascular risk among men with low FVC.},
  author       = {Engström, Gunnar and Lind, P and Hedblad, Bo and Wollmer, Per and Stavenow, L and Janzon, Lars and Lindgärde, Folke},
  issn         = {1524-4539},
  keyword      = {Human,Adult,Blood Proteins: analysis,Cardiovascular Diseases: epidemiology,Cardiovascular Diseases: mortality,Cohort Studies,Follow-Up Studies,Inflammation: blood,Male,Myocardial Infarction: epidemiology,Middle Age,Incidence,Vital Capacity,Survival Analysis,Prospective Studies,Risk Factors,Support,Non-U.S. Gov't},
  language     = {eng},
  number       = {20},
  pages        = {2555--2560},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Circulation},
  title        = {Lung function and cardiovascular risk: relationship with inflammation-sensitive plasma proteins.},
  url          = {http://dx.doi.org/10.1161/01.CIR.0000037220.00065.0D},
  volume       = {106},
  year         = {2002},
}