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Menopausal Complaints Are Associated With Cardiovascular Risk Factors.

Gast, Gerrie-Cor M; Grobbee, Diederick E; Pop, Victor J M; Keyzer, Jules J; Wijnands-van Gent, Colette J M; Samsioe, Göran LU ; Nilsson, Peter LU and van der Schouw, Yvonne T (2008) In Hypertension 51(6). p.1492-1498
Abstract
It has been hypothesized that women with vasomotor symptoms differ from those without with respect to cardiovascular risk factors or responses to exogenous hormone therapy. We studied whether the presence and extent of menopausal complaints are associated with cardiovascular risk profile. Data were used from a population-based sample of 5523 women, aged 46 to 57 years, enrolled between 1994 and 1995. Data on menopausal complaints and potential confounders were collected by questionnaires. Total cholesterol, systolic and diastolic blood pressures, and body mass index were measured. Linear and logistic regression analyses were used to analyze the data. Night sweats were reported by 38% and flushing by 39% of women. After multivariate... (More)
It has been hypothesized that women with vasomotor symptoms differ from those without with respect to cardiovascular risk factors or responses to exogenous hormone therapy. We studied whether the presence and extent of menopausal complaints are associated with cardiovascular risk profile. Data were used from a population-based sample of 5523 women, aged 46 to 57 years, enrolled between 1994 and 1995. Data on menopausal complaints and potential confounders were collected by questionnaires. Total cholesterol, systolic and diastolic blood pressures, and body mass index were measured. Linear and logistic regression analyses were used to analyze the data. Night sweats were reported by 38% and flushing by 39% of women. After multivariate adjustment, women with complaints of flushing had a 0.27-mmol/L (95% CI: 0.15 to 0.39) higher cholesterol level, a 0.60-kg/m(2) (95% CI: 0.35 to 0.84) higher BMI, a 1.59-mm Hg (95% CI: 0.52 to 2.67) higher systolic blood pressure, and a 1.09-mm Hg (95% CI: 0.48 to 1.69) higher diastolic blood pressure compared with asymptomatic women. Flushing was also associated with hypercholesterolemia (odds ratio: 1.52; 95% CI: 1.25 to 1.84) and hypertension (OR: 1.20; 95% CI: 1.07 to 1.34). Results were similar for complaints of night sweating. The findings support the view that menopausal complaints are associated with a less favorable cardiovascular risk profile. These findings substantiate the view that differences in the presence of menopausal symptoms as a reason for using hormone therapy could explain discrepant findings between observational research and trials. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Hypertension
volume
51
issue
6
pages
1492 - 1498
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000256053500018
  • pmid:18391100
  • scopus:45849101221
ISSN
1524-4563
DOI
10.1161/HYPERTENSIONAHA.107.106526
language
English
LU publication?
yes
id
18e46745-5b60-4695-90d9-16dfcfbbab87 (old id 1147743)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18391100?dopt=Abstract
date added to LUP
2009-07-10 11:12:09
date last changed
2017-09-17 05:04:31
@article{18e46745-5b60-4695-90d9-16dfcfbbab87,
  abstract     = {It has been hypothesized that women with vasomotor symptoms differ from those without with respect to cardiovascular risk factors or responses to exogenous hormone therapy. We studied whether the presence and extent of menopausal complaints are associated with cardiovascular risk profile. Data were used from a population-based sample of 5523 women, aged 46 to 57 years, enrolled between 1994 and 1995. Data on menopausal complaints and potential confounders were collected by questionnaires. Total cholesterol, systolic and diastolic blood pressures, and body mass index were measured. Linear and logistic regression analyses were used to analyze the data. Night sweats were reported by 38% and flushing by 39% of women. After multivariate adjustment, women with complaints of flushing had a 0.27-mmol/L (95% CI: 0.15 to 0.39) higher cholesterol level, a 0.60-kg/m(2) (95% CI: 0.35 to 0.84) higher BMI, a 1.59-mm Hg (95% CI: 0.52 to 2.67) higher systolic blood pressure, and a 1.09-mm Hg (95% CI: 0.48 to 1.69) higher diastolic blood pressure compared with asymptomatic women. Flushing was also associated with hypercholesterolemia (odds ratio: 1.52; 95% CI: 1.25 to 1.84) and hypertension (OR: 1.20; 95% CI: 1.07 to 1.34). Results were similar for complaints of night sweating. The findings support the view that menopausal complaints are associated with a less favorable cardiovascular risk profile. These findings substantiate the view that differences in the presence of menopausal symptoms as a reason for using hormone therapy could explain discrepant findings between observational research and trials.},
  author       = {Gast, Gerrie-Cor M and Grobbee, Diederick E and Pop, Victor J M and Keyzer, Jules J and Wijnands-van Gent, Colette J M and Samsioe, Göran and Nilsson, Peter and van der Schouw, Yvonne T},
  issn         = {1524-4563},
  language     = {eng},
  number       = {6},
  pages        = {1492--1498},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Hypertension},
  title        = {Menopausal Complaints Are Associated With Cardiovascular Risk Factors.},
  url          = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.106526},
  volume       = {51},
  year         = {2008},
}