Comparison of CGRP and NO responses in the human peripheral microcirculation of migraine and control subjects.
(2008) In Cephalalgia 28(5). p.563-566- Abstract
- Calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are two molecules shown to have a role in migraine pathophysiology. Our objective was to test the hypothesis that migraine subjects are particularly sensitive to these signal molecules. The cutaneous microvascular responses to endothelial and non-endothelial dependent dilators were tested using laser Doppler flowmetry in combination with iontophoresis. The blood flow responses to iontophoretic administration of the endothelium-dependent vasodilator acetylcholine (ACh), or to the endothelium-independent dilators sodium nitroprusside (SNP) and CGRP, and to local warming (44 degrees C) were compared in this controlled trial. The design was that of two arms: patients diagnosed with... (More)
- Calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are two molecules shown to have a role in migraine pathophysiology. Our objective was to test the hypothesis that migraine subjects are particularly sensitive to these signal molecules. The cutaneous microvascular responses to endothelial and non-endothelial dependent dilators were tested using laser Doppler flowmetry in combination with iontophoresis. The blood flow responses to iontophoretic administration of the endothelium-dependent vasodilator acetylcholine (ACh), or to the endothelium-independent dilators sodium nitroprusside (SNP) and CGRP, and to local warming (44 degrees C) were compared in this controlled trial. The design was that of two arms: patients diagnosed with migraine without aura (n = 9) for >10 years were compared with nine healthy subjects matched for age and gender (seven female and two male, age range 30-60 years). Iontophoretic administration resulted in local vasodilation. ACh induced a relaxation of 1225 +/- 245% (relative to baseline) in controls and 1468 +/- 368% (P > 0.05) in migraine. The responses to SNP were 873 +/- 193% in controls and 1080 +/- 102% (P > 0.05) in migraine subjects. The responses to CGRP were 565 +/- 89% in controls and 746 +/- 675% (P > 0.05) in migraine patients. The responses to local heating which induced maximum dilation did not differ between the groups (1976 +/- 314% for controls and 1432 +/- 226% in migraine; P > 0.05. We conclude that there is no change in the microvascular responsiveness of the subcutaneous microvasculature in migraine. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1147843
- author
- Edvinsson, M-L and Edvinsson, Lars LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cephalalgia
- volume
- 28
- issue
- 5
- pages
- 563 - 566
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000254789300012
- pmid:18384419
- scopus:41849112045
- ISSN
- 0333-1024
- DOI
- 10.1111/j.1468-2982.2008.01558.x
- language
- English
- LU publication?
- yes
- id
- 4d450c27-8fd1-443e-97fc-56d061ccdd8f (old id 1147843)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18384419?dopt=Abstract
- date added to LUP
- 2016-04-04 09:14:17
- date last changed
- 2024-01-12 10:49:28
@article{4d450c27-8fd1-443e-97fc-56d061ccdd8f,
abstract = {{Calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are two molecules shown to have a role in migraine pathophysiology. Our objective was to test the hypothesis that migraine subjects are particularly sensitive to these signal molecules. The cutaneous microvascular responses to endothelial and non-endothelial dependent dilators were tested using laser Doppler flowmetry in combination with iontophoresis. The blood flow responses to iontophoretic administration of the endothelium-dependent vasodilator acetylcholine (ACh), or to the endothelium-independent dilators sodium nitroprusside (SNP) and CGRP, and to local warming (44 degrees C) were compared in this controlled trial. The design was that of two arms: patients diagnosed with migraine without aura (n = 9) for >10 years were compared with nine healthy subjects matched for age and gender (seven female and two male, age range 30-60 years). Iontophoretic administration resulted in local vasodilation. ACh induced a relaxation of 1225 +/- 245% (relative to baseline) in controls and 1468 +/- 368% (P > 0.05) in migraine. The responses to SNP were 873 +/- 193% in controls and 1080 +/- 102% (P > 0.05) in migraine subjects. The responses to CGRP were 565 +/- 89% in controls and 746 +/- 675% (P > 0.05) in migraine patients. The responses to local heating which induced maximum dilation did not differ between the groups (1976 +/- 314% for controls and 1432 +/- 226% in migraine; P > 0.05. We conclude that there is no change in the microvascular responsiveness of the subcutaneous microvasculature in migraine.}},
author = {{Edvinsson, M-L and Edvinsson, Lars}},
issn = {{0333-1024}},
language = {{eng}},
number = {{5}},
pages = {{563--566}},
publisher = {{Wiley-Blackwell}},
series = {{Cephalalgia}},
title = {{Comparison of CGRP and NO responses in the human peripheral microcirculation of migraine and control subjects.}},
url = {{http://dx.doi.org/10.1111/j.1468-2982.2008.01558.x}},
doi = {{10.1111/j.1468-2982.2008.01558.x}},
volume = {{28}},
year = {{2008}},
}