Associations between cerebral blood-flow measured by single photon emission tomography (SPECT), electro-encephalogram (EEG), behaviour symptoms and neurological soft signs in children with attention-deficit hyperactivity disorder (ADHD)
Gustafsson, Peik LU
; Thernlund, Gunilla
LU
; Ryding, Erik
LU
; Rosén, Ingmar
LU
and Cederblad, Marianne
LU
(2000)
In Acta Pædiatrica
89(7).
p.830-835
- Abstract
- Twenty-eight children with attention-deficit hyperactivity disorder (ADHD) were examined with SPECT (single photon emission computed tomography). Seven of the children had abnormal distribution of the regional cerebral blood-flow (rCBF) on visual evaluation and 10 had abnormal EEG findings. The only clinical finding that differentiated the group with normal from abnormal rCBF was behaviour symptom load. A factor analysis of the rCBF in different regions of interest
yielded one factor with low rCBF in the temporal and cerebellar regions and high rCBF in the subcortical and thalamic regions, which was significantly associated with the degree of motor impairment and results on a cognitive test (WISC). Another factor consisting of... (More) - Twenty-eight children with attention-deficit hyperactivity disorder (ADHD) were examined with SPECT (single photon emission computed tomography). Seven of the children had abnormal distribution of the regional cerebral blood-flow (rCBF) on visual evaluation and 10 had abnormal EEG findings. The only clinical finding that differentiated the group with normal from abnormal rCBF was behaviour symptom load. A factor analysis of the rCBF in different regions of interest
yielded one factor with low rCBF in the temporal and cerebellar regions and high rCBF in the subcortical and thalamic regions, which was significantly associated with the degree of motor impairment and results on a cognitive test (WISC). Another factor consisting of high rCBF in frontal and parietal regions had a significant negative correlation with the degree of behaviour symptoms. There was a negative correlation between the rCBF in the right frontal regions and the degree of behaviour symptoms. The number of minor physical anomalies (MPA) was negatively correlated to the rCBF in the frontal lobes bilaterally. These results suggest that there may be at least two functional disturbances in ADHD, one specific neurodevelopmentally determined disturbance of the frontal lobes, especially of the right hemisphere, related to behaviour deviance, and another disturbance of the integration of the temporal lobes, the
cerebellum and subcortical structures, related to motor planning and aspects of cognition. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1150041
- author
- Gustafsson, Peik
LU
; Thernlund, Gunilla
LU
; Ryding, Erik
LU
; Rosén, Ingmar
LU
and Cederblad, Marianne
LU
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- SPECT, child behaviour problem, soft neurological signs, WISC, Key words: ADHD
- in
- Acta Pædiatrica
- volume
- 89
- issue
- 7
- pages
- 830 - 835
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:10943967
- scopus:0033867664
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2000.tb00391.x
- language
- English
- LU publication?
- yes
- id
- e59eff4e-95ad-493b-8964-8fa1446fe87c (old id 1150041)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/10943967
- http://onlinelibrary.wiley.com/doi/10.1111/j.1651-2227.2000.tb00391.x/abstract
- date added to LUP
- 2016-04-01 15:55:31
- date last changed
- 2024-02-26 09:45:19
@article{e59eff4e-95ad-493b-8964-8fa1446fe87c,
abstract = {{Twenty-eight children with attention-deficit hyperactivity disorder (ADHD) were examined with SPECT (single photon emission computed tomography). Seven of the children had abnormal distribution of the regional cerebral blood-flow (rCBF) on visual evaluation and 10 had abnormal EEG findings. The only clinical finding that differentiated the group with normal from abnormal rCBF was behaviour symptom load. A factor analysis of the rCBF in different regions of interest<br/><br>
yielded one factor with low rCBF in the temporal and cerebellar regions and high rCBF in the subcortical and thalamic regions, which was significantly associated with the degree of motor impairment and results on a cognitive test (WISC). Another factor consisting of high rCBF in frontal and parietal regions had a significant negative correlation with the degree of behaviour symptoms. There was a negative correlation between the rCBF in the right frontal regions and the degree of behaviour symptoms. The number of minor physical anomalies (MPA) was negatively correlated to the rCBF in the frontal lobes bilaterally. These results suggest that there may be at least two functional disturbances in ADHD, one specific neurodevelopmentally determined disturbance of the frontal lobes, especially of the right hemisphere, related to behaviour deviance, and another disturbance of the integration of the temporal lobes, the<br/><br>
cerebellum and subcortical structures, related to motor planning and aspects of cognition.}},
author = {{Gustafsson, Peik and Thernlund, Gunilla and Ryding, Erik and Rosén, Ingmar and Cederblad, Marianne}},
issn = {{1651-2227}},
keywords = {{SPECT; child behaviour problem; soft neurological signs; WISC; Key words: ADHD}},
language = {{eng}},
number = {{7}},
pages = {{830--835}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Pædiatrica}},
title = {{Associations between cerebral blood-flow measured by single photon emission tomography (SPECT), electro-encephalogram (EEG), behaviour symptoms and neurological soft signs in children with attention-deficit hyperactivity disorder (ADHD)}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2000.tb00391.x}},
doi = {{10.1111/j.1651-2227.2000.tb00391.x}},
volume = {{89}},
year = {{2000}},
}