Advanced

Associations between cerebral blood-flow measured by single photon emission tomography (SPECT), electro-encephalogram (EEG), behaviour symptoms and neurological soft signs in children with attention-deficit hyperactivity disorder (ADHD)

Gustafsson, Peik LU ; Thernlund, Gunilla LU ; Ryding, Erik LU ; Rosén, Ingmar LU and Cederblad, Marianne LU (2000) In Acta Pædiatrica 89(7). p.830-835
Abstract
Twenty-eight children with attention-deficit hyperactivity disorder (ADHD) were examined with SPECT (single photon emission computed tomography). Seven of the children had abnormal distribution of the regional cerebral blood-flow (rCBF) on visual evaluation and 10 had abnormal EEG findings. The only clinical finding that differentiated the group with normal from abnormal rCBF was behaviour symptom load. A factor analysis of the rCBF in different regions of interest

yielded one factor with low rCBF in the temporal and cerebellar regions and high rCBF in the subcortical and thalamic regions, which was significantly associated with the degree of motor impairment and results on a cognitive test (WISC). Another factor consisting of... (More)
Twenty-eight children with attention-deficit hyperactivity disorder (ADHD) were examined with SPECT (single photon emission computed tomography). Seven of the children had abnormal distribution of the regional cerebral blood-flow (rCBF) on visual evaluation and 10 had abnormal EEG findings. The only clinical finding that differentiated the group with normal from abnormal rCBF was behaviour symptom load. A factor analysis of the rCBF in different regions of interest

yielded one factor with low rCBF in the temporal and cerebellar regions and high rCBF in the subcortical and thalamic regions, which was significantly associated with the degree of motor impairment and results on a cognitive test (WISC). Another factor consisting of high rCBF in frontal and parietal regions had a significant negative correlation with the degree of behaviour symptoms. There was a negative correlation between the rCBF in the right frontal regions and the degree of behaviour symptoms. The number of minor physical anomalies (MPA) was negatively correlated to the rCBF in the frontal lobes bilaterally. These results suggest that there may be at least two functional disturbances in ADHD, one specific neurodevelopmentally determined disturbance of the frontal lobes, especially of the right hemisphere, related to behaviour deviance, and another disturbance of the integration of the temporal lobes, the

cerebellum and subcortical structures, related to motor planning and aspects of cognition. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SPECT, child behaviour problem, soft neurological signs, WISC, Key words: ADHD
in
Acta Pædiatrica
volume
89
issue
7
pages
830 - 835
publisher
Taylor & Francis
external identifiers
  • pmid:10943967
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2000.tb00391.x
language
English
LU publication?
yes
id
e59eff4e-95ad-493b-8964-8fa1446fe87c (old id 1150041)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/10943967
http://onlinelibrary.wiley.com/doi/10.1111/j.1651-2227.2000.tb00391.x/abstract
date added to LUP
2013-08-06 15:34:14
date last changed
2016-04-16 03:33:31
@article{e59eff4e-95ad-493b-8964-8fa1446fe87c,
  abstract     = {Twenty-eight children with attention-deficit hyperactivity disorder (ADHD) were examined with SPECT (single photon emission computed tomography). Seven of the children had abnormal distribution of the regional cerebral blood-flow (rCBF) on visual evaluation and 10 had abnormal EEG findings. The only clinical finding that differentiated the group with normal from abnormal rCBF was behaviour symptom load. A factor analysis of the rCBF in different regions of interest<br/><br>
yielded one factor with low rCBF in the temporal and cerebellar regions and high rCBF in the subcortical and thalamic regions, which was significantly associated with the degree of motor impairment and results on a cognitive test (WISC). Another factor consisting of high rCBF in frontal and parietal regions had a significant negative correlation with the degree of behaviour symptoms. There was a negative correlation between the rCBF in the right frontal regions and the degree of behaviour symptoms. The number of minor physical anomalies (MPA) was negatively correlated to the rCBF in the frontal lobes bilaterally. These results suggest that there may be at least two functional disturbances in ADHD, one specific neurodevelopmentally determined disturbance of the frontal lobes, especially of the right hemisphere, related to behaviour deviance, and another disturbance of the integration of the temporal lobes, the<br/><br>
cerebellum and subcortical structures, related to motor planning and aspects of cognition.},
  author       = {Gustafsson, Peik and Thernlund, Gunilla and Ryding, Erik and Rosén, Ingmar and Cederblad, Marianne},
  issn         = {1651-2227},
  keyword      = {SPECT,child behaviour problem,soft neurological signs,WISC,Key words: ADHD},
  language     = {eng},
  number       = {7},
  pages        = {830--835},
  publisher    = {Taylor & Francis},
  series       = {Acta Pædiatrica},
  title        = {Associations between cerebral blood-flow measured by single photon emission tomography (SPECT), electro-encephalogram (EEG), behaviour symptoms and neurological soft signs in children with attention-deficit hyperactivity disorder (ADHD)},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2000.tb00391.x},
  volume       = {89},
  year         = {2000},
}