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Surface activity of tear fluid in patients with primary Sjögren's syndrome.

Zhao, Jiang; Manthorpe, Rolf LU and Wollmer, Per LU (2002) In Clinical Physiology and Functional Imaging2002-01-01+01:00 22(1). p.24-27
Abstract
Rupture of the preocular tear film leads to formation of a dry spot on the cornea with ocular irritation and symptoms of dry eye. One of the factors determining the stability of the tear film is its surface activity. The purpose of this study was to examine the surface activity of tear fluid from patients with Sjögren's syndrome. Tear fluid was sampled from the eyes of 16 patients with primary Sjögren's syndrome. The surface activity of the sample was measured on a Wilhelmy balance. Maximum and minimum surface tension was 72·2 ± 1·7 and 52·9 ± 7·4 mN m-1, respectively. Corresponding values in a previously studied group of normal subjects were 71·5 ± 1·3 and 46·6 ± 3·8 mN m-1, respectively. The difference in minimal surface tension was... (More)
Rupture of the preocular tear film leads to formation of a dry spot on the cornea with ocular irritation and symptoms of dry eye. One of the factors determining the stability of the tear film is its surface activity. The purpose of this study was to examine the surface activity of tear fluid from patients with Sjögren's syndrome. Tear fluid was sampled from the eyes of 16 patients with primary Sjögren's syndrome. The surface activity of the sample was measured on a Wilhelmy balance. Maximum and minimum surface tension was 72·2 ± 1·7 and 52·9 ± 7·4 mN m-1, respectively. Corresponding values in a previously studied group of normal subjects were 71·5 ± 1·3 and 46·6 ± 3·8 mN m-1, respectively. The difference in minimal surface tension was statistically significant (P<0·001). Reduced surface activity may be caused by dysfunction of the Meibomian glands and suggests a mechanism for causing the symptoms of dry eyes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Female, Human, Adolescent, Adult, Aged, Middle Age, Reference Values, Sjogren's Syndrome: metabolism, Support, Non-U.S. Gov't, Surface Tension, Tears: chemistry
in
Clinical Physiology and Functional Imaging2002-01-01+01:00
volume
22
issue
1
pages
24 - 27
publisher
Wiley Online Library
external identifiers
  • wos:000174885800007
  • pmid:12003095
  • scopus:0037069773
ISSN
1475-0961
DOI
10.1046/j.1475-097X.2002.00389.x
language
English
LU publication?
yes
id
86389199-ea21-48ee-8005-8e2fd655608c (old id 115363)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12003095&dopt=AbstractPlus
date added to LUP
2007-07-30 11:33:01
date last changed
2017-10-22 03:43:53
@article{86389199-ea21-48ee-8005-8e2fd655608c,
  abstract     = {Rupture of the preocular tear film leads to formation of a dry spot on the cornea with ocular irritation and symptoms of dry eye. One of the factors determining the stability of the tear film is its surface activity. The purpose of this study was to examine the surface activity of tear fluid from patients with Sjögren's syndrome. Tear fluid was sampled from the eyes of 16 patients with primary Sjögren's syndrome. The surface activity of the sample was measured on a Wilhelmy balance. Maximum and minimum surface tension was 72·2 ± 1·7 and 52·9 ± 7·4 mN m-1, respectively. Corresponding values in a previously studied group of normal subjects were 71·5 ± 1·3 and 46·6 ± 3·8 mN m-1, respectively. The difference in minimal surface tension was statistically significant (P&lt;0·001). Reduced surface activity may be caused by dysfunction of the Meibomian glands and suggests a mechanism for causing the symptoms of dry eyes.},
  author       = {Zhao, Jiang and Manthorpe, Rolf and Wollmer, Per},
  issn         = {1475-0961},
  keyword      = {Female,Human,Adolescent,Adult,Aged,Middle Age,Reference Values,Sjogren's Syndrome: metabolism,Support,Non-U.S. Gov't,Surface Tension,Tears: chemistry},
  language     = {eng},
  number       = {1},
  pages        = {24--27},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging2002-01-01+01:00},
  title        = {Surface activity of tear fluid in patients with primary Sjögren's syndrome.},
  url          = {http://dx.doi.org/10.1046/j.1475-097X.2002.00389.x},
  volume       = {22},
  year         = {2002},
}