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Antimicrobial peptides in innate immune responses.

Sørensen, Ole E LU ; Borregaard, Niels and Cole, Alexander M (2008) In Contributions to Microbiology 15. p.61-77
Abstract
Antimicrobial peptides (AMPs) are ancient effector molecules in the innate immune response of eukaryotes. These peptides are important for the antimicrobial efficacy of phagocytes and for the innate immune response mounted by epithelia of humans and other mammals. AMPs are generated either by de novo synthesis or by proteolytic cleavage from antimicrobially inactive proproteins. Studies of human diseases and animal studies have given important clues to the in vivo role of AMPs. It is now evident that dysregulation of the generation of AMPs in innate immune responses plays a role in certain diseases like Crohn's disease and atopic dermatitis. AMPs are attractive candidates for development of novel antibiotics due to their in vivo activity... (More)
Antimicrobial peptides (AMPs) are ancient effector molecules in the innate immune response of eukaryotes. These peptides are important for the antimicrobial efficacy of phagocytes and for the innate immune response mounted by epithelia of humans and other mammals. AMPs are generated either by de novo synthesis or by proteolytic cleavage from antimicrobially inactive proproteins. Studies of human diseases and animal studies have given important clues to the in vivo role of AMPs. It is now evident that dysregulation of the generation of AMPs in innate immune responses plays a role in certain diseases like Crohn's disease and atopic dermatitis. AMPs are attractive candidates for development of novel antibiotics due to their in vivo activity profile and some peptides may serve as templates for further drug development. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contributions to Microbiology
volume
15
pages
61 - 77
publisher
Karger
external identifiers
  • pmid:18511856
  • scopus:49449097856
ISSN
1420-9519
DOI
10.1159/000136315
language
English
LU publication?
yes
id
d7387a08-df33-48c5-961c-5219e428e36f (old id 1153671)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18511856
http://www.karger.com/Article/Abstract/136315
date added to LUP
2013-08-09 15:18:03
date last changed
2017-08-27 04:46:49
@article{d7387a08-df33-48c5-961c-5219e428e36f,
  abstract     = {Antimicrobial peptides (AMPs) are ancient effector molecules in the innate immune response of eukaryotes. These peptides are important for the antimicrobial efficacy of phagocytes and for the innate immune response mounted by epithelia of humans and other mammals. AMPs are generated either by de novo synthesis or by proteolytic cleavage from antimicrobially inactive proproteins. Studies of human diseases and animal studies have given important clues to the in vivo role of AMPs. It is now evident that dysregulation of the generation of AMPs in innate immune responses plays a role in certain diseases like Crohn's disease and atopic dermatitis. AMPs are attractive candidates for development of novel antibiotics due to their in vivo activity profile and some peptides may serve as templates for further drug development.},
  author       = {Sørensen, Ole E and Borregaard, Niels and Cole, Alexander M},
  issn         = {1420-9519},
  language     = {eng},
  pages        = {61--77},
  publisher    = {Karger},
  series       = {Contributions to Microbiology},
  title        = {Antimicrobial peptides in innate immune responses.},
  url          = {http://dx.doi.org/10.1159/000136315},
  volume       = {15},
  year         = {2008},
}