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Adjuvant tamoxifen in breast cancer patients affects the endometrium by time, an effect remaining years after end of treatment and results in an increased frequency of endometrial carcinoma.

Lindahl, Bengt LU ; Andolf, Ellika; Ingvar, Christian LU ; Ranstam, Jonas LU and Willén, Roger (2008) In Anticancer Research 28(2B). p.1259-1262
Abstract
Tamoxifen is the most used adjuvant drug in breast cancer treatment. Its main action is as an anti-oestrogen, but in the endometrium of some patients it acts as an oestrogen. Some investigators have even reported an increased risk of developing endometrial carcinoma. The question of how to follow-up these patients and how to identify patients at risk of developing endometrial premalignant changes was investigated by the noninvasive ultrasound method. The follow-up of 292 patients from before the start of adjuvant treatment with tamoxifen and 94 without tamoxifen treatment was conducted at regular intervals. The changes in endometrial thickness as measured by ultrasound and histopathological changes are reported. A thicker endometrium was... (More)
Tamoxifen is the most used adjuvant drug in breast cancer treatment. Its main action is as an anti-oestrogen, but in the endometrium of some patients it acts as an oestrogen. Some investigators have even reported an increased risk of developing endometrial carcinoma. The question of how to follow-up these patients and how to identify patients at risk of developing endometrial premalignant changes was investigated by the noninvasive ultrasound method. The follow-up of 292 patients from before the start of adjuvant treatment with tamoxifen and 94 without tamoxifen treatment was conducted at regular intervals. The changes in endometrial thickness as measured by ultrasound and histopathological changes are reported. A thicker endometrium was found in patients with receptor positive breast cancer even before the treatment with tamoxifen started. Cumulative increasing thickness was found during treatment and this thicker endometrium remained until almost 3 years after the end of treatment. If the endometrium was <3 mm after 3 months of treatment the probability that it would be thin after 5 years was high. An increased risk of developing endometrial carcinoma was found, however due to this regular follow-up the cancer was identified at an early stage. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anticancer Research
volume
28
issue
2B
pages
1259 - 1262
publisher
International Institute of Cancer Research
external identifiers
  • wos:000255254300016
  • pmid:18505063
  • scopus:42649102676
ISSN
1791-7530
language
English
LU publication?
yes
id
d9c7eb0d-e00e-49a8-9bd0-1044a1cfbcc1 (old id 1153729)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18505063?dopt=Abstract
date added to LUP
2008-06-02 11:39:10
date last changed
2017-01-01 07:38:04
@article{d9c7eb0d-e00e-49a8-9bd0-1044a1cfbcc1,
  abstract     = {Tamoxifen is the most used adjuvant drug in breast cancer treatment. Its main action is as an anti-oestrogen, but in the endometrium of some patients it acts as an oestrogen. Some investigators have even reported an increased risk of developing endometrial carcinoma. The question of how to follow-up these patients and how to identify patients at risk of developing endometrial premalignant changes was investigated by the noninvasive ultrasound method. The follow-up of 292 patients from before the start of adjuvant treatment with tamoxifen and 94 without tamoxifen treatment was conducted at regular intervals. The changes in endometrial thickness as measured by ultrasound and histopathological changes are reported. A thicker endometrium was found in patients with receptor positive breast cancer even before the treatment with tamoxifen started. Cumulative increasing thickness was found during treatment and this thicker endometrium remained until almost 3 years after the end of treatment. If the endometrium was &lt;3 mm after 3 months of treatment the probability that it would be thin after 5 years was high. An increased risk of developing endometrial carcinoma was found, however due to this regular follow-up the cancer was identified at an early stage.},
  author       = {Lindahl, Bengt and Andolf, Ellika and Ingvar, Christian and Ranstam, Jonas and Willén, Roger},
  issn         = {1791-7530},
  language     = {eng},
  number       = {2B},
  pages        = {1259--1262},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {Adjuvant tamoxifen in breast cancer patients affects the endometrium by time, an effect remaining years after end of treatment and results in an increased frequency of endometrial carcinoma.},
  volume       = {28},
  year         = {2008},
}