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Definitive endoderm: a key step in coaxing human embryonic stem cells into transplantable beta-cells.

Semb, Henrik LU (2008) In Biochemical Society Transactions 36(Pt 3). p.272-275
Abstract
Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be widely available, it will require an unlimited source of cells to serve as a 'biological' insulin pump. At this time, the development of beta-cells from hESCs (human embryonic stem cells) has emerged as the most attractive alternative. It is envisioned that ultimate success of an in vitro approach to programme hESCs into beta-cells will depend on the ability, at least to a certain degree, to sequentially reproduce the... (More)
Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be widely available, it will require an unlimited source of cells to serve as a 'biological' insulin pump. At this time, the development of beta-cells from hESCs (human embryonic stem cells) has emerged as the most attractive alternative. It is envisioned that ultimate success of an in vitro approach to programme hESCs into beta-cells will depend on the ability, at least to a certain degree, to sequentially reproduce the individual steps that characterizes normal beta-cell ontogenesis during fetal pancreatic development, including definitive endoderm from which all gastrointestinal organs, including the pancreas, originate. In the present article, differentiation of hESCs into putative definitive endodermal cell types is reviewed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical Society Transactions
volume
36
issue
Pt 3
pages
272 - 275
publisher
Biochemical Society
external identifiers
  • wos:000256609000002
  • pmid:18481940
  • scopus:45249096927
ISSN
0300-5127
DOI
10.1042/BST0360272
language
English
LU publication?
yes
id
f91ed80c-b46d-475a-ade0-65214c5f4ccc (old id 1154099)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18481940?dopt=Abstract
date added to LUP
2008-06-05 09:18:06
date last changed
2017-01-01 07:40:45
@article{f91ed80c-b46d-475a-ade0-65214c5f4ccc,
  abstract     = {Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be widely available, it will require an unlimited source of cells to serve as a 'biological' insulin pump. At this time, the development of beta-cells from hESCs (human embryonic stem cells) has emerged as the most attractive alternative. It is envisioned that ultimate success of an in vitro approach to programme hESCs into beta-cells will depend on the ability, at least to a certain degree, to sequentially reproduce the individual steps that characterizes normal beta-cell ontogenesis during fetal pancreatic development, including definitive endoderm from which all gastrointestinal organs, including the pancreas, originate. In the present article, differentiation of hESCs into putative definitive endodermal cell types is reviewed.},
  author       = {Semb, Henrik},
  issn         = {0300-5127},
  language     = {eng},
  number       = {Pt 3},
  pages        = {272--275},
  publisher    = {Biochemical Society},
  series       = {Biochemical Society Transactions},
  title        = {Definitive endoderm: a key step in coaxing human embryonic stem cells into transplantable beta-cells.},
  url          = {http://dx.doi.org/10.1042/BST0360272},
  volume       = {36},
  year         = {2008},
}