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Epidemiology of severe Streptococcus pyogenes disease in Europe.

Lamagni, Theresa L; Darenberg, Jessica; Luca, Bogdan LU ; Siljander, Tuula; Efstratiou, Androulla; Henriques-Normark, Birgitta; Vuopio-Varkila, Jaana; Bouvet, Anne; Creti, Roberta and Ekelund, Kim, et al. (2008) In Journal of Clinical Microbiology 46(7). p.2359-2367
Abstract
The past two decades have brought worrying increases in severe Streptococcus pyogenes diseases globally. To investigate and compare the epidemiological patterns of these diseases within Europe, data on severe S. pyogenes infections were collected through an EU FP-5 funded programme (Strep-EURO). Prospective population-based surveillance of severe S. pyogenes infection diagnosed during 2003 and 2004 was undertaken in eleven countries across Europe (Cyprus, Czech Republic, Denmark, Finland, France, Germany, Greece, Italy, Romania, Sweden, UK) using a standardised case definition. A total of 5522 cases of severe S. pyogenes infection were identified across the eleven countries during this period. Rates of reported infection varied, reaching... (More)
The past two decades have brought worrying increases in severe Streptococcus pyogenes diseases globally. To investigate and compare the epidemiological patterns of these diseases within Europe, data on severe S. pyogenes infections were collected through an EU FP-5 funded programme (Strep-EURO). Prospective population-based surveillance of severe S. pyogenes infection diagnosed during 2003 and 2004 was undertaken in eleven countries across Europe (Cyprus, Czech Republic, Denmark, Finland, France, Germany, Greece, Italy, Romania, Sweden, UK) using a standardised case definition. A total of 5522 cases of severe S. pyogenes infection were identified across the eleven countries during this period. Rates of reported infection varied, reaching 3/100,000 population in the northern European countries. Seasonal patterns of infections showed remarkable congruence between countries. Risk of infection was highest among the elderly, with rates being higher in males than females in most countries. Skin lesions/wounds were the most common predisposing factor, reported in 25% of cases; 21% had no predisposing factors reported. Skin and soft tissue was the most common focus of infection, 32% of patients having cellulitis and 8% necrotizing fasciitis. The overall 7-day case fatality rate was 19%, 44% among cases who developed streptococcal toxic shock syndrome. Findings from Strep-EURO confirm a high incidence of severe S. pyogenes disease in Europe. Furthermore, these results have identified targets for public health intervention, as well as raising awareness of severe S. pyogenes disease across Europe. (Less)
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Journal of Clinical Microbiology
volume
46
issue
7
pages
2359 - 2367
publisher
American Society for Microbiology
external identifiers
  • wos:000258906800032
  • pmid:18463210
  • scopus:49049116579
ISSN
1098-660X
DOI
10.1128/JCM.00422-08
language
English
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yes
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ceed7d67-c1bb-4766-a6ac-3967e9780820 (old id 1154443)
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http://www.ncbi.nlm.nih.gov/pubmed/18463210?dopt=Abstract
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2008-06-03 14:21:24
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@article{ceed7d67-c1bb-4766-a6ac-3967e9780820,
  abstract     = {The past two decades have brought worrying increases in severe Streptococcus pyogenes diseases globally. To investigate and compare the epidemiological patterns of these diseases within Europe, data on severe S. pyogenes infections were collected through an EU FP-5 funded programme (Strep-EURO). Prospective population-based surveillance of severe S. pyogenes infection diagnosed during 2003 and 2004 was undertaken in eleven countries across Europe (Cyprus, Czech Republic, Denmark, Finland, France, Germany, Greece, Italy, Romania, Sweden, UK) using a standardised case definition. A total of 5522 cases of severe S. pyogenes infection were identified across the eleven countries during this period. Rates of reported infection varied, reaching 3/100,000 population in the northern European countries. Seasonal patterns of infections showed remarkable congruence between countries. Risk of infection was highest among the elderly, with rates being higher in males than females in most countries. Skin lesions/wounds were the most common predisposing factor, reported in 25% of cases; 21% had no predisposing factors reported. Skin and soft tissue was the most common focus of infection, 32% of patients having cellulitis and 8% necrotizing fasciitis. The overall 7-day case fatality rate was 19%, 44% among cases who developed streptococcal toxic shock syndrome. Findings from Strep-EURO confirm a high incidence of severe S. pyogenes disease in Europe. Furthermore, these results have identified targets for public health intervention, as well as raising awareness of severe S. pyogenes disease across Europe.},
  author       = {Lamagni, Theresa L and Darenberg, Jessica and Luca, Bogdan and Siljander, Tuula and Efstratiou, Androulla and Henriques-Normark, Birgitta and Vuopio-Varkila, Jaana and Bouvet, Anne and Creti, Roberta and Ekelund, Kim and Koliou, Maria and Reinert, Ralf René and Stathi, Angeliki and Strakova, Lenka and Ungureanu, Vasilica and Schalén, Claës and Jasir, Aftab},
  issn         = {1098-660X},
  language     = {eng},
  number       = {7},
  pages        = {2359--2367},
  publisher    = {American Society for Microbiology},
  series       = {Journal of Clinical Microbiology},
  title        = {Epidemiology of severe Streptococcus pyogenes disease in Europe.},
  url          = {http://dx.doi.org/10.1128/JCM.00422-08},
  volume       = {46},
  year         = {2008},
}