Xylosylated naphthoic acid-amino acid conjugates for investigation of glycosaminoglycan priming.
Abrahamsson, Carl-Olof ; Ellervik, Ulf LU
; Eriksson Bajtner, Johan
LU
; Jacobsson, Mårten
LU
and Mani, Katrin
LU
(2008)
In Carbohydrate Research
343(9).
p.1473-1477
- Abstract
- Three different series of xylosylated naphthoic acid-amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of normal lung fibroblasts to some extent, whereas the growth of tumor derived T24 carcinoma cells was not affected. There was no correlation between amino acid conjugation, retention time and the antiproliferative activity. Only one compound initiated the priming of glycosaminoglycans. Modification of the naphthalene ring with one or two amino acid residues did not have any effect on proteoglycan biosynthesis or glycosaminoglycan priming in T24 carcinoma... (More)
- Three different series of xylosylated naphthoic acid-amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of normal lung fibroblasts to some extent, whereas the growth of tumor derived T24 carcinoma cells was not affected. There was no correlation between amino acid conjugation, retention time and the antiproliferative activity. Only one compound initiated the priming of glycosaminoglycans. Modification of the naphthalene ring with one or two amino acid residues did not have any effect on proteoglycan biosynthesis or glycosaminoglycan priming in T24 carcinoma cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1154603
- author
- Abrahamsson, Carl-Olof
; Ellervik, Ulf
LU
; Eriksson Bajtner, Johan
LU
; Jacobsson, Mårten
LU
and Mani, Katrin
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Carbohydrate Research
- volume
- 343
- issue
- 9
- pages
- 1473 - 1477
- publisher
- Elsevier
- external identifiers
-
- wos:000257280300009
- pmid:18452896
- scopus:44449159726
- pmid:18452896
- ISSN
- 1873-426X
- DOI
- 10.1016/j.carres.2008.04.006
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Experimental Medical Science (013210000), Organic chemistry (S/LTH) (011001240), Glycobiology (013212006)
- id
- 3c25e6d5-15ff-4fce-9a2d-07360400fd16 (old id 1154603)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18452896?dopt=Abstract
- date added to LUP
- 2016-04-01 12:09:47
- date last changed
- 2024-01-08 10:38:00
@article{3c25e6d5-15ff-4fce-9a2d-07360400fd16,
abstract = {{Three different series of xylosylated naphthoic acid-amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of normal lung fibroblasts to some extent, whereas the growth of tumor derived T24 carcinoma cells was not affected. There was no correlation between amino acid conjugation, retention time and the antiproliferative activity. Only one compound initiated the priming of glycosaminoglycans. Modification of the naphthalene ring with one or two amino acid residues did not have any effect on proteoglycan biosynthesis or glycosaminoglycan priming in T24 carcinoma cells.}},
author = {{Abrahamsson, Carl-Olof and Ellervik, Ulf and Eriksson Bajtner, Johan and Jacobsson, Mårten and Mani, Katrin}},
issn = {{1873-426X}},
language = {{eng}},
number = {{9}},
pages = {{1473--1477}},
publisher = {{Elsevier}},
series = {{Carbohydrate Research}},
title = {{Xylosylated naphthoic acid-amino acid conjugates for investigation of glycosaminoglycan priming.}},
url = {{http://dx.doi.org/10.1016/j.carres.2008.04.006}},
doi = {{10.1016/j.carres.2008.04.006}},
volume = {{343}},
year = {{2008}},
}