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Xylosylated naphthoic acid-amino acid conjugates for investigation of glycosaminoglycan priming.

Abrahamsson, Carl-Olof; Ellervik, Ulf LU ; Eriksson Bajtner, Johan LU ; Jacobsson, Mårten LU and Mani, Katrin LU (2008) In Carbohydrate Research 343(9). p.1473-1477
Abstract
Three different series of xylosylated naphthoic acid-amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of normal lung fibroblasts to some extent, whereas the growth of tumor derived T24 carcinoma cells was not affected. There was no correlation between amino acid conjugation, retention time and the antiproliferative activity. Only one compound initiated the priming of glycosaminoglycans. Modification of the naphthalene ring with one or two amino acid residues did not have any effect on proteoglycan biosynthesis or glycosaminoglycan priming in T24 carcinoma... (More)
Three different series of xylosylated naphthoic acid-amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of normal lung fibroblasts to some extent, whereas the growth of tumor derived T24 carcinoma cells was not affected. There was no correlation between amino acid conjugation, retention time and the antiproliferative activity. Only one compound initiated the priming of glycosaminoglycans. Modification of the naphthalene ring with one or two amino acid residues did not have any effect on proteoglycan biosynthesis or glycosaminoglycan priming in T24 carcinoma cells. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Carbohydrate Research
volume
343
issue
9
pages
1473 - 1477
publisher
Elsevier
external identifiers
  • wos:000257280300009
  • pmid:18452896
  • scopus:44449159726
ISSN
1873-426X
DOI
10.1016/j.carres.2008.04.006
language
English
LU publication?
yes
id
3c25e6d5-15ff-4fce-9a2d-07360400fd16 (old id 1154603)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18452896?dopt=Abstract
date added to LUP
2008-06-04 12:29:08
date last changed
2017-11-05 03:40:06
@article{3c25e6d5-15ff-4fce-9a2d-07360400fd16,
  abstract     = {Three different series of xylosylated naphthoic acid-amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of normal lung fibroblasts to some extent, whereas the growth of tumor derived T24 carcinoma cells was not affected. There was no correlation between amino acid conjugation, retention time and the antiproliferative activity. Only one compound initiated the priming of glycosaminoglycans. Modification of the naphthalene ring with one or two amino acid residues did not have any effect on proteoglycan biosynthesis or glycosaminoglycan priming in T24 carcinoma cells.},
  author       = {Abrahamsson, Carl-Olof and Ellervik, Ulf and Eriksson Bajtner, Johan and Jacobsson, Mårten and Mani, Katrin},
  issn         = {1873-426X},
  language     = {eng},
  number       = {9},
  pages        = {1473--1477},
  publisher    = {Elsevier},
  series       = {Carbohydrate Research},
  title        = {Xylosylated naphthoic acid-amino acid conjugates for investigation of glycosaminoglycan priming.},
  url          = {http://dx.doi.org/10.1016/j.carres.2008.04.006},
  volume       = {343},
  year         = {2008},
}