Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines.
(2002) In BMC Dermatology 2(1).- Abstract
- Objective
To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold.
Methods
Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM).
Results
Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients.
Conclusions
Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute... (More) - Objective
To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold.
Methods
Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM).
Results
Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients.
Conclusions
Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/115560
- author
- Svensson, Åke LU ; Möller, Halvor LU ; Björkner, Bert LU ; Bruze, Magnus LU ; Leden, Ido ; Theander, Jan ; Ohlsson, Kjell and Linder, Carina LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Dermatology
- volume
- 2
- issue
- 1
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:2942535835
- ISSN
- 1471-5945
- DOI
- 10.1186/1471-5945-2-2
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Dermatology (013241300), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 00134d2a-c9c4-4b8a-9e1f-d141cb2794e2 (old id 115560)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11860615&dopt=Abstract
- date added to LUP
- 2016-04-01 16:48:11
- date last changed
- 2022-01-28 22:17:38
@article{00134d2a-c9c4-4b8a-9e1f-d141cb2794e2,
abstract = {{Objective<br/><br>
<br/><br>
To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold.<br/><br>
Methods<br/><br>
<br/><br>
Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM).<br/><br>
Results<br/><br>
<br/><br>
Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients.<br/><br>
Conclusions<br/><br>
<br/><br>
Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose.}},
author = {{Svensson, Åke and Möller, Halvor and Björkner, Bert and Bruze, Magnus and Leden, Ido and Theander, Jan and Ohlsson, Kjell and Linder, Carina}},
issn = {{1471-5945}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Dermatology}},
title = {{Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines.}},
url = {{https://lup.lub.lu.se/search/files/4784961/623804.pdf}},
doi = {{10.1186/1471-5945-2-2}},
volume = {{2}},
year = {{2002}},
}