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Deodorants: an experimental provocation study with hydroxycitronellal.

Svedman, Cecilia LU ; Bruze, Magnus LU ; Johansen, J D; Andersen, K E; Goossens, A.; Frosch, P J; Lepoittevin, J-P; Rastogi, S; White, I R and Menné, T (2003) In Contact Dermatitis 48(4). p.217-223
Abstract
Axillary dermatitis is a common problem, particularly in individuals with contact allergy to fragrances. Many individuals suspect their deodorant to be the causal product of their fragrance allergy. It has been shown that deodorants containing cinnamic aldehyde (cinnamal) can elicit axillary dermatitis in patients sensitized to this substance. The aim of the present investigation was to evaluate the importance of hydroxycitronellal used in deodorants for the development of axillary dermatitis, when applied by individuals with and without contact allergy to this fragrance chemical. Patch tests with deodorants and ethanolic solutions containing hydroxycitronellal, as well as repeated open application tests (ROAT) with roll-on deodorants with... (More)
Axillary dermatitis is a common problem, particularly in individuals with contact allergy to fragrances. Many individuals suspect their deodorant to be the causal product of their fragrance allergy. It has been shown that deodorants containing cinnamic aldehyde (cinnamal) can elicit axillary dermatitis in patients sensitized to this substance. The aim of the present investigation was to evaluate the importance of hydroxycitronellal used in deodorants for the development of axillary dermatitis, when applied by individuals with and without contact allergy to this fragrance chemical. Patch tests with deodorants and ethanolic solutions containing hydroxycitronellal, as well as repeated open application tests (ROAT) with roll-on deodorants with and without hydroxycitronellal at different concentrations, were performed in 14 dermatitis patients, 7 with and 7 without contact allergy to hydroxycitronellal. A positive ROAT was noted only in the patients hypersensitive to hydroxycitronellal (P < 0·001) and only in the axilla to which the deodorants containing hydroxycitronellal had been applied (P < 0·001). Deodorants containing hydroxycitronellal in the concentration range of 0·032–0·32% used twice daily on healthy skin in individuals hypersensitive to hydroxycitronellal can elicit axillary dermatitis in a few weeks. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
48
issue
4
pages
217 - 223
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:12786728
  • wos:000183693500009
  • scopus:0038798516
ISSN
0105-1873
DOI
10.1034/j.1600-0536.2003.00094.x
language
English
LU publication?
yes
id
1b8e0e18-f7e8-4983-92b7-a3361776c389 (old id 116147)
date added to LUP
2007-07-30 10:43:11
date last changed
2018-01-07 05:19:28
@article{1b8e0e18-f7e8-4983-92b7-a3361776c389,
  abstract     = {Axillary dermatitis is a common problem, particularly in individuals with contact allergy to fragrances. Many individuals suspect their deodorant to be the causal product of their fragrance allergy. It has been shown that deodorants containing cinnamic aldehyde (cinnamal) can elicit axillary dermatitis in patients sensitized to this substance. The aim of the present investigation was to evaluate the importance of hydroxycitronellal used in deodorants for the development of axillary dermatitis, when applied by individuals with and without contact allergy to this fragrance chemical. Patch tests with deodorants and ethanolic solutions containing hydroxycitronellal, as well as repeated open application tests (ROAT) with roll-on deodorants with and without hydroxycitronellal at different concentrations, were performed in 14 dermatitis patients, 7 with and 7 without contact allergy to hydroxycitronellal. A positive ROAT was noted only in the patients hypersensitive to hydroxycitronellal (P &lt; 0·001) and only in the axilla to which the deodorants containing hydroxycitronellal had been applied (P &lt; 0·001). Deodorants containing hydroxycitronellal in the concentration range of 0·032–0·32% used twice daily on healthy skin in individuals hypersensitive to hydroxycitronellal can elicit axillary dermatitis in a few weeks.},
  author       = {Svedman, Cecilia and Bruze, Magnus and Johansen, J D and Andersen, K E and Goossens, A. and Frosch, P J and Lepoittevin, J-P and Rastogi, S and White, I R and Menné, T},
  issn         = {0105-1873},
  language     = {eng},
  number       = {4},
  pages        = {217--223},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Deodorants: an experimental provocation study with hydroxycitronellal.},
  url          = {http://dx.doi.org/10.1034/j.1600-0536.2003.00094.x},
  volume       = {48},
  year         = {2003},
}