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Suicidal Intent and the HPA-Axis Characteristics of Suicide Attempters with Major Depressive Disorder and Adjustment Disorders.

Lindqvist, Daniel LU ; Träskman Bendz, Lil LU and Vang, Fredrik (2008) In Archives of Suicide Research 12(3). p.197-207
Abstract
The main purpose of the study was to investigate Hypothalamic-Pituitary-Adrenal (HPA) axis characteristics in relation to suicidal intent among suicide attempters with Major Depressive Disorder (MDD) and Adjustment Disorders (AD). The relationship between suicidal intent, assessed by means of the Suicidal Intent Scale (SIS), and serum cortisol after a Dexamethasone Suppression Test (DST) was investigated in 78 suicide attempters, divided into diagnostic subgroups. There was a significant negative correlation between suicidal intent and post DST cortisol in patients with MDD. Our findings may be attributed to pathophysiological processes, where a high suicidal intent is revealed during a potential chronic course of MDD, which in turnresults... (More)
The main purpose of the study was to investigate Hypothalamic-Pituitary-Adrenal (HPA) axis characteristics in relation to suicidal intent among suicide attempters with Major Depressive Disorder (MDD) and Adjustment Disorders (AD). The relationship between suicidal intent, assessed by means of the Suicidal Intent Scale (SIS), and serum cortisol after a Dexamethasone Suppression Test (DST) was investigated in 78 suicide attempters, divided into diagnostic subgroups. There was a significant negative correlation between suicidal intent and post DST cortisol in patients with MDD. Our findings may be attributed to pathophysiological processes, where a high suicidal intent is revealed during a potential chronic course of MDD, which in turnresults in a seemingly normal stress system. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dexamethasone suppression test, adjustment disorders, HPA-axis, major depressive disorder, suicidal intent, suicide
in
Archives of Suicide Research
volume
12
issue
3
pages
197 - 207
publisher
Routledge
external identifiers
  • wos:000207510100002
  • pmid:18576201
  • scopus:46049116649
ISSN
1543-6136
DOI
10.1080/13811110802100775
language
English
LU publication?
yes
id
486f0a03-dab7-4785-9b18-33c880f5047a (old id 1168453)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18576201?dopt=Abstract
date added to LUP
2008-07-02 13:26:06
date last changed
2017-05-14 03:55:07
@article{486f0a03-dab7-4785-9b18-33c880f5047a,
  abstract     = {The main purpose of the study was to investigate Hypothalamic-Pituitary-Adrenal (HPA) axis characteristics in relation to suicidal intent among suicide attempters with Major Depressive Disorder (MDD) and Adjustment Disorders (AD). The relationship between suicidal intent, assessed by means of the Suicidal Intent Scale (SIS), and serum cortisol after a Dexamethasone Suppression Test (DST) was investigated in 78 suicide attempters, divided into diagnostic subgroups. There was a significant negative correlation between suicidal intent and post DST cortisol in patients with MDD. Our findings may be attributed to pathophysiological processes, where a high suicidal intent is revealed during a potential chronic course of MDD, which in turnresults in a seemingly normal stress system.},
  author       = {Lindqvist, Daniel and Träskman Bendz, Lil and Vang, Fredrik},
  issn         = {1543-6136},
  keyword      = {dexamethasone suppression test,adjustment disorders,HPA-axis,major depressive disorder,suicidal intent,suicide},
  language     = {eng},
  number       = {3},
  pages        = {197--207},
  publisher    = {Routledge},
  series       = {Archives of Suicide Research},
  title        = {Suicidal Intent and the HPA-Axis Characteristics of Suicide Attempters with Major Depressive Disorder and Adjustment Disorders.},
  url          = {http://dx.doi.org/10.1080/13811110802100775},
  volume       = {12},
  year         = {2008},
}